Epigenetics: New questions on the response to hypoxia

Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger changes at both cellular and systemic levels to recover oxygen hom...

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Autores principales:	Perez-Perri, J.I., Acevedo, J.M., Wappner, P.
Formato:	JOUR
Materias:	Chromatin HIF Histone Jumonji Oxygen Stress histone acetyltransferase histone acetyltransferase PCAF histone deacetylase histone deacetylase 1 histone deacetylase 4 histone deacetylase 5 histone deacetylase 7 histone demethylase hypoxia inducible factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha sirtuin 1 chromatin histone chromatin assembly and disassembly chromatin structure DNA methylation epigenetics gene activation gene expression regulation gene induction gene repression histone acetylation histone methylation histone modification homeostasis hypoxia nonhuman review transcription initiation animal anoxia chemistry genetics human metabolism Mammalia Animals Anoxia Epigenomics Histone Acetyltransferases Histone Deacetylases Histones Humans
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14220067_v12_n7_p4705_PerezPerri
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_14220067_v12_n7_p4705_PerezPerri
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spelling	todo:paper_14220067_v12_n7_p4705_PerezPerri2023-10-03T16:13:32Z Epigenetics: New questions on the response to hypoxia Perez-Perri, J.I. Acevedo, J.M. Wappner, P. Chromatin HIF Histone Jumonji Oxygen Stress histone acetyltransferase histone acetyltransferase PCAF histone deacetylase histone deacetylase 1 histone deacetylase 4 histone deacetylase 5 histone deacetylase 7 histone demethylase hypoxia inducible factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha sirtuin 1 chromatin histone histone acetyltransferase histone deacetylase chromatin assembly and disassembly chromatin structure DNA methylation epigenetics gene activation gene expression regulation gene induction gene repression histone acetylation histone methylation histone modification homeostasis hypoxia nonhuman review transcription initiation animal anoxia chemistry chromatin genetics human metabolism Mammalia Animals Anoxia Chromatin Epigenomics Histone Acetyltransferases Histone Deacetylases Histones Humans Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger changes at both cellular and systemic levels to recover oxygen homeostasis. Most of these processes are mediated by Hypoxia Inducible Factors, HIFs, a family of transcription factors that directly induce the expression of several hundred genes in mammalian cells. Although different aspects of HIF regulation are well known, it is still unclear by which precise mechanism HIFs activate transcription of their target genes. Concomitantly, hypoxia provokes a dramatic decrease of general transcription that seems to rely in part on epigenetic changes through a poorly understood mechanism. In this review we discuss the current knowledge on chromatin changes involved in HIF dependent gene activation, as well as on other epigenetic changes, not necessarily linked to HIF that take place under hypoxic conditions. © 2011 by the authors. Fil:Acevedo, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Wappner, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14220067_v12_n7_p4705_PerezPerri
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Chromatin HIF Histone Jumonji Oxygen Stress histone acetyltransferase histone acetyltransferase PCAF histone deacetylase histone deacetylase 1 histone deacetylase 4 histone deacetylase 5 histone deacetylase 7 histone demethylase hypoxia inducible factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha sirtuin 1 chromatin histone histone acetyltransferase histone deacetylase chromatin assembly and disassembly chromatin structure DNA methylation epigenetics gene activation gene expression regulation gene induction gene repression histone acetylation histone methylation histone modification homeostasis hypoxia nonhuman review transcription initiation animal anoxia chemistry chromatin genetics human metabolism Mammalia Animals Anoxia Chromatin Epigenomics Histone Acetyltransferases Histone Deacetylases Histones Humans
spellingShingle	Chromatin HIF Histone Jumonji Oxygen Stress histone acetyltransferase histone acetyltransferase PCAF histone deacetylase histone deacetylase 1 histone deacetylase 4 histone deacetylase 5 histone deacetylase 7 histone demethylase hypoxia inducible factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha sirtuin 1 chromatin histone histone acetyltransferase histone deacetylase chromatin assembly and disassembly chromatin structure DNA methylation epigenetics gene activation gene expression regulation gene induction gene repression histone acetylation histone methylation histone modification homeostasis hypoxia nonhuman review transcription initiation animal anoxia chemistry chromatin genetics human metabolism Mammalia Animals Anoxia Chromatin Epigenomics Histone Acetyltransferases Histone Deacetylases Histones Humans Perez-Perri, J.I. Acevedo, J.M. Wappner, P. Epigenetics: New questions on the response to hypoxia
topic_facet	Chromatin HIF Histone Jumonji Oxygen Stress histone acetyltransferase histone acetyltransferase PCAF histone deacetylase histone deacetylase 1 histone deacetylase 4 histone deacetylase 5 histone deacetylase 7 histone demethylase hypoxia inducible factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha sirtuin 1 chromatin histone histone acetyltransferase histone deacetylase chromatin assembly and disassembly chromatin structure DNA methylation epigenetics gene activation gene expression regulation gene induction gene repression histone acetylation histone methylation histone modification homeostasis hypoxia nonhuman review transcription initiation animal anoxia chemistry chromatin genetics human metabolism Mammalia Animals Anoxia Chromatin Epigenomics Histone Acetyltransferases Histone Deacetylases Histones Humans
description	Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger changes at both cellular and systemic levels to recover oxygen homeostasis. Most of these processes are mediated by Hypoxia Inducible Factors, HIFs, a family of transcription factors that directly induce the expression of several hundred genes in mammalian cells. Although different aspects of HIF regulation are well known, it is still unclear by which precise mechanism HIFs activate transcription of their target genes. Concomitantly, hypoxia provokes a dramatic decrease of general transcription that seems to rely in part on epigenetic changes through a poorly understood mechanism. In this review we discuss the current knowledge on chromatin changes involved in HIF dependent gene activation, as well as on other epigenetic changes, not necessarily linked to HIF that take place under hypoxic conditions. © 2011 by the authors.
format	JOUR
author	Perez-Perri, J.I. Acevedo, J.M. Wappner, P.
author_facet	Perez-Perri, J.I. Acevedo, J.M. Wappner, P.
author_sort	Perez-Perri, J.I.
title	Epigenetics: New questions on the response to hypoxia
title_short	Epigenetics: New questions on the response to hypoxia
title_full	Epigenetics: New questions on the response to hypoxia
title_fullStr	Epigenetics: New questions on the response to hypoxia
title_full_unstemmed	Epigenetics: New questions on the response to hypoxia
title_sort	epigenetics: new questions on the response to hypoxia
url	http://hdl.handle.net/20.500.12110/paper_14220067_v12_n7_p4705_PerezPerri
work_keys_str_mv	AT perezperriji epigeneticsnewquestionsontheresponsetohypoxia AT acevedojm epigeneticsnewquestionsontheresponsetohypoxia AT wappnerp epigeneticsnewquestionsontheresponsetohypoxia
_version_	1807315150757167104

Epigenetics: New questions on the response to hypoxia

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