Cytotoxic tirucallane triterpenoids from Melia azedarach fruits

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The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4...

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Detalles Bibliográficos
Autores principales: Ntalli, N.G., Cottiglia, F., Bueno, C.A., Alché, L.E., Leonti, M., Vargiu, S., Bifulco, E., Menkissoglu-Spiroudi, U., Caboni, P.
Formato: JOUR
Materias:
21-β-Acetoxy- melianone
3-α-Tigloylmelianol
Cytotoxicity
Melianone
Methyl kulonate
cytotoxin
plant extract
tirucallane
triterpene
adenocarcinoma
animal
article
chemical structure
chemistry
drug effect
epithelium cell
fruit
human
isolation and purification
lung tumor
Melia azedarach
nematode
pathology
tumor cell line
Adenocarcinoma
Animals
Cell Line, Tumor
Cytotoxins
Epithelial Cells
Fruit
Humans
Lung Neoplasms
Molecular Structure
Plant Extracts
Triterpenes
Tylenchoidea
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_14203049_v15_n9_p5866_Ntalli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita. © 2010 by the authors.

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