Cytotoxic tirucallane triterpenoids from Melia azedarach fruits

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The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4...

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Autores principales:	Ntalli, N.G., Cottiglia, F., Bueno, C.A., Alché, L.E., Leonti, M., Vargiu, S., Bifulco, E., Menkissoglu-Spiroudi, U., Caboni, P.
Formato:	JOUR
Materias:	21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Molecular Structure Plant Extracts Triterpenes Tylenchoidea
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14203049_v15_n9_p5866_Ntalli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_14203049_v15_n9_p5866_Ntalli
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spelling	todo:paper_14203049_v15_n9_p5866_Ntalli2023-10-03T16:13:13Z Cytotoxic tirucallane triterpenoids from Melia azedarach fruits Ntalli, N.G. Cottiglia, F. Bueno, C.A. Alché, L.E. Leonti, M. Vargiu, S. Bifulco, E. Menkissoglu-Spiroudi, U. Caboni, P. 21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Melia azedarach Molecular Structure Plant Extracts Triterpenes Tylenchoidea The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita. © 2010 by the authors. Fil:Bueno, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alché, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14203049_v15_n9_p5866_Ntalli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Melia azedarach Molecular Structure Plant Extracts Triterpenes Tylenchoidea
spellingShingle	21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Melia azedarach Molecular Structure Plant Extracts Triterpenes Tylenchoidea Ntalli, N.G. Cottiglia, F. Bueno, C.A. Alché, L.E. Leonti, M. Vargiu, S. Bifulco, E. Menkissoglu-Spiroudi, U. Caboni, P. Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
topic_facet	21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Melia azedarach Molecular Structure Plant Extracts Triterpenes Tylenchoidea
description	The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita. © 2010 by the authors.
format	JOUR
author	Ntalli, N.G. Cottiglia, F. Bueno, C.A. Alché, L.E. Leonti, M. Vargiu, S. Bifulco, E. Menkissoglu-Spiroudi, U. Caboni, P.
author_facet	Ntalli, N.G. Cottiglia, F. Bueno, C.A. Alché, L.E. Leonti, M. Vargiu, S. Bifulco, E. Menkissoglu-Spiroudi, U. Caboni, P.
author_sort	Ntalli, N.G.
title	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_short	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_full	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_fullStr	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_full_unstemmed	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_sort	cytotoxic tirucallane triterpenoids from melia azedarach fruits
url	http://hdl.handle.net/20.500.12110/paper_14203049_v15_n9_p5866_Ntalli
work_keys_str_mv	AT ntalling cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT cottigliaf cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT buenoca cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT alchele cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT leontim cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT vargius cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT bifulcoe cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT menkissogluspiroudiu cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT cabonip cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits
_version_	1782025891588603904

Cytotoxic tirucallane triterpenoids from Melia azedarach fruits

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