New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.
The recent advances in the chemistry of carbocyclic nucleosides focused on different synthetic approaches that lead to optically pure products as well as a comprehensive overview of their biological properties are discussed. In the latter aspect, molecular recognition of enzymes of pharmacological i...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_13895575_v3_n2_p95_Rodriguez |
| Aporte de: |
| id |
todo:paper_13895575_v3_n2_p95_Rodriguez |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_13895575_v3_n2_p95_Rodriguez2023-10-03T16:12:45Z New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. Rodríguez, J.B. Comin, M.J. 2',3' dideoxynucleoside derivative alkanone anti human immunodeficiency virus agent antineoplastic agent carbovir cyclohexane derivative cyclopentane derivative cyclopropane derivative glyceraldehyde glycoside nucleoside chemistry conformation cyclization human review stereoisomerism synthesis Anti-HIV Agents Antineoplastic Agents Butanones Cyclization Cyclohexanes Cyclopentanes Cyclopropanes Dideoxynucleosides Glyceraldehyde Glycosides Humans Molecular Conformation Nucleosides Stereoisomerism The recent advances in the chemistry of carbocyclic nucleosides focused on different synthetic approaches that lead to optically pure products as well as a comprehensive overview of their biological properties are discussed. In the latter aspect, molecular recognition of enzymes of pharmacological importance such as: reverse transcriptase, adenosine deaminase, thymidine kinase, DNA cytosine-C5 methyl transferase, S-adenosylhomocysteine hydrolase, etc are considered. The role of conformation and puckering of the glycon moiety in modulating the biological activity and also the use of carbanucleosides as building blocks to prepare oligonucleotides are carefully illustrated. Fil:Rodríguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Comin, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13895575_v3_n2_p95_Rodriguez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
2',3' dideoxynucleoside derivative alkanone anti human immunodeficiency virus agent antineoplastic agent carbovir cyclohexane derivative cyclopentane derivative cyclopropane derivative glyceraldehyde glycoside nucleoside chemistry conformation cyclization human review stereoisomerism synthesis Anti-HIV Agents Antineoplastic Agents Butanones Cyclization Cyclohexanes Cyclopentanes Cyclopropanes Dideoxynucleosides Glyceraldehyde Glycosides Humans Molecular Conformation Nucleosides Stereoisomerism |
| spellingShingle |
2',3' dideoxynucleoside derivative alkanone anti human immunodeficiency virus agent antineoplastic agent carbovir cyclohexane derivative cyclopentane derivative cyclopropane derivative glyceraldehyde glycoside nucleoside chemistry conformation cyclization human review stereoisomerism synthesis Anti-HIV Agents Antineoplastic Agents Butanones Cyclization Cyclohexanes Cyclopentanes Cyclopropanes Dideoxynucleosides Glyceraldehyde Glycosides Humans Molecular Conformation Nucleosides Stereoisomerism Rodríguez, J.B. Comin, M.J. New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. |
| topic_facet |
2',3' dideoxynucleoside derivative alkanone anti human immunodeficiency virus agent antineoplastic agent carbovir cyclohexane derivative cyclopentane derivative cyclopropane derivative glyceraldehyde glycoside nucleoside chemistry conformation cyclization human review stereoisomerism synthesis Anti-HIV Agents Antineoplastic Agents Butanones Cyclization Cyclohexanes Cyclopentanes Cyclopropanes Dideoxynucleosides Glyceraldehyde Glycosides Humans Molecular Conformation Nucleosides Stereoisomerism |
| description |
The recent advances in the chemistry of carbocyclic nucleosides focused on different synthetic approaches that lead to optically pure products as well as a comprehensive overview of their biological properties are discussed. In the latter aspect, molecular recognition of enzymes of pharmacological importance such as: reverse transcriptase, adenosine deaminase, thymidine kinase, DNA cytosine-C5 methyl transferase, S-adenosylhomocysteine hydrolase, etc are considered. The role of conformation and puckering of the glycon moiety in modulating the biological activity and also the use of carbanucleosides as building blocks to prepare oligonucleotides are carefully illustrated. |
| format |
JOUR |
| author |
Rodríguez, J.B. Comin, M.J. |
| author_facet |
Rodríguez, J.B. Comin, M.J. |
| author_sort |
Rodríguez, J.B. |
| title |
New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. |
| title_short |
New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. |
| title_full |
New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. |
| title_fullStr |
New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. |
| title_full_unstemmed |
New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. |
| title_sort |
new progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. |
| url |
http://hdl.handle.net/20.500.12110/paper_13895575_v3_n2_p95_Rodriguez |
| work_keys_str_mv |
AT rodriguezjb newprogressesintheenantioselectivesynthesisandbiologicalpropertiesofcarbocyclicnucleosides AT cominmj newprogressesintheenantioselectivesynthesisandbiologicalpropertiesofcarbocyclicnucleosides |
| _version_ |
1782025278337318912 |