Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support
Nucleoside analogue synthesis has received much attention because of the wide range of applications that these molecules offer. They are extensively used as antiviral, antitumor and more recently, as starting materials for functional oligonucleotides. Microbial whole cells are efficient, ecological...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_13811177_v52-53_n1-4_p189_Trelles |
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todo:paper_13811177_v52-53_n1-4_p189_Trelles2023-10-03T16:11:46Z Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support Trelles, J.A. Bentancor, L. Grasselli, M. Lewkowicz, E.S. Iribarren, A.M. Adenosine Escherichia coli BL21 Nucleoside phosphorylases Polyethylene Whole cell immobilization Adenosine Antitumors Nucleoside phosphorylases Nucleosides Cell immobilization Enzymes Escherichia coli Graft copolymers Synthesis (chemical) Polyethylenes antineoplastic agent antisense oligonucleotide antivirus agent nucleoside oligonucleotide polyethylene polyglycidyl methacrylate ethylenediamine polymer unclassified drug article biocatalyst catalyst support cost minimization analysis drug synthesis immobilized cell molecular stability nucleic acid synthesis pharmaceutical engineering porosity process development productivity Escherichia coli Nucleoside analogue synthesis has received much attention because of the wide range of applications that these molecules offer. They are extensively used as antiviral, antitumor and more recently, as starting materials for functional oligonucleotides. Microbial whole cells are efficient, ecological and low cost biocatalysts that have been successfully applied to the preparation of these compounds. A new support for cell immobilization that involves the use of a macroporous polyethylene polymer grafted with chains of polyglycidyl methacrylate-ethylendiamine is described in this paper. High stability and productivity and easy handling are some of the advantages of the here developed biocatalyst. © 2007 Elsevier B.V. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13811177_v52-53_n1-4_p189_Trelles |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Adenosine Escherichia coli BL21 Nucleoside phosphorylases Polyethylene Whole cell immobilization Adenosine Antitumors Nucleoside phosphorylases Nucleosides Cell immobilization Enzymes Escherichia coli Graft copolymers Synthesis (chemical) Polyethylenes antineoplastic agent antisense oligonucleotide antivirus agent nucleoside oligonucleotide polyethylene polyglycidyl methacrylate ethylenediamine polymer unclassified drug article biocatalyst catalyst support cost minimization analysis drug synthesis immobilized cell molecular stability nucleic acid synthesis pharmaceutical engineering porosity process development productivity Escherichia coli |
| spellingShingle |
Adenosine Escherichia coli BL21 Nucleoside phosphorylases Polyethylene Whole cell immobilization Adenosine Antitumors Nucleoside phosphorylases Nucleosides Cell immobilization Enzymes Escherichia coli Graft copolymers Synthesis (chemical) Polyethylenes antineoplastic agent antisense oligonucleotide antivirus agent nucleoside oligonucleotide polyethylene polyglycidyl methacrylate ethylenediamine polymer unclassified drug article biocatalyst catalyst support cost minimization analysis drug synthesis immobilized cell molecular stability nucleic acid synthesis pharmaceutical engineering porosity process development productivity Escherichia coli Trelles, J.A. Bentancor, L. Grasselli, M. Lewkowicz, E.S. Iribarren, A.M. Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support |
| topic_facet |
Adenosine Escherichia coli BL21 Nucleoside phosphorylases Polyethylene Whole cell immobilization Adenosine Antitumors Nucleoside phosphorylases Nucleosides Cell immobilization Enzymes Escherichia coli Graft copolymers Synthesis (chemical) Polyethylenes antineoplastic agent antisense oligonucleotide antivirus agent nucleoside oligonucleotide polyethylene polyglycidyl methacrylate ethylenediamine polymer unclassified drug article biocatalyst catalyst support cost minimization analysis drug synthesis immobilized cell molecular stability nucleic acid synthesis pharmaceutical engineering porosity process development productivity Escherichia coli |
| description |
Nucleoside analogue synthesis has received much attention because of the wide range of applications that these molecules offer. They are extensively used as antiviral, antitumor and more recently, as starting materials for functional oligonucleotides. Microbial whole cells are efficient, ecological and low cost biocatalysts that have been successfully applied to the preparation of these compounds. A new support for cell immobilization that involves the use of a macroporous polyethylene polymer grafted with chains of polyglycidyl methacrylate-ethylendiamine is described in this paper. High stability and productivity and easy handling are some of the advantages of the here developed biocatalyst. © 2007 Elsevier B.V. All rights reserved. |
| format |
JOUR |
| author |
Trelles, J.A. Bentancor, L. Grasselli, M. Lewkowicz, E.S. Iribarren, A.M. |
| author_facet |
Trelles, J.A. Bentancor, L. Grasselli, M. Lewkowicz, E.S. Iribarren, A.M. |
| author_sort |
Trelles, J.A. |
| title |
Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support |
| title_short |
Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support |
| title_full |
Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support |
| title_fullStr |
Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support |
| title_full_unstemmed |
Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support |
| title_sort |
nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support |
| url |
http://hdl.handle.net/20.500.12110/paper_13811177_v52-53_n1-4_p189_Trelles |
| work_keys_str_mv |
AT trellesja nucleosidesynthesisusinganovelmacroporousgraftedpolyethyleneasbiocatalystsupport AT bentancorl nucleosidesynthesisusinganovelmacroporousgraftedpolyethyleneasbiocatalystsupport AT grassellim nucleosidesynthesisusinganovelmacroporousgraftedpolyethyleneasbiocatalystsupport AT lewkowiczes nucleosidesynthesisusinganovelmacroporousgraftedpolyethyleneasbiocatalystsupport AT iribarrenam nucleosidesynthesisusinganovelmacroporousgraftedpolyethyleneasbiocatalystsupport |
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