Vascular galectins: Regulators of tumor progression and targets for cancer therapy
Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and growth factor-like functions in multiple steps of cancer progression. They contribute to tumor cell transformation, promote tumor angiogenesis, hamper the anti-tumor immune response, and facilitate tumor metas...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_13596101_v24_n6_p547_Thijssen |
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todo:paper_13596101_v24_n6_p547_Thijssen2023-10-03T16:10:37Z Vascular galectins: Regulators of tumor progression and targets for cancer therapy Thijssen, V.L. Rabinovich, G.A. Griffioen, A.W. Angiogenesis Endothelial cells Endothelium Immune response Metastasis 6 hydroxilpropylacylfulvene anginex antineoplastic agent bevacizumab ecalectin galectin galectin 1 galectin 10 galectin 12 galectin 13 galectin 14 galectin 2 galectin 3 galectin 4 galectin 7 galectin 8 unclassified drug angiogenesis breast cancer cancer growth cancer therapy cell function drug targeting endothelium cell human immune response metastasis multiple myeloma nonhuman priority journal prostate cancer protein expression regulatory mechanism review tumor escape tumor immunity tumor vascularization Angiogenesis Endothelial cells Endothelium Immune response Metastasis Animals Disease Progression Endothelium, Vascular Galectins Humans Neoplasms Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and growth factor-like functions in multiple steps of cancer progression. They contribute to tumor cell transformation, promote tumor angiogenesis, hamper the anti-tumor immune response, and facilitate tumor metastasis. Consequently, galectins are considered as multifunctional targets for cancer therapy. Interestingly, many of the functions related to tumor progression can be linked to galectins expressed by endothelial cells in the tumor vascular bed. Since the tumor vasculature is an easily accessible target for cancer therapy, understanding how galectins in the tumor endothelium influence cancer progression is important for the translational development of galectin-targeting therapies. © 2013 Elsevier Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13596101_v24_n6_p547_Thijssen |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiogenesis Endothelial cells Endothelium Immune response Metastasis 6 hydroxilpropylacylfulvene anginex antineoplastic agent bevacizumab ecalectin galectin galectin 1 galectin 10 galectin 12 galectin 13 galectin 14 galectin 2 galectin 3 galectin 4 galectin 7 galectin 8 unclassified drug angiogenesis breast cancer cancer growth cancer therapy cell function drug targeting endothelium cell human immune response metastasis multiple myeloma nonhuman priority journal prostate cancer protein expression regulatory mechanism review tumor escape tumor immunity tumor vascularization Angiogenesis Endothelial cells Endothelium Immune response Metastasis Animals Disease Progression Endothelium, Vascular Galectins Humans Neoplasms |
| spellingShingle |
Angiogenesis Endothelial cells Endothelium Immune response Metastasis 6 hydroxilpropylacylfulvene anginex antineoplastic agent bevacizumab ecalectin galectin galectin 1 galectin 10 galectin 12 galectin 13 galectin 14 galectin 2 galectin 3 galectin 4 galectin 7 galectin 8 unclassified drug angiogenesis breast cancer cancer growth cancer therapy cell function drug targeting endothelium cell human immune response metastasis multiple myeloma nonhuman priority journal prostate cancer protein expression regulatory mechanism review tumor escape tumor immunity tumor vascularization Angiogenesis Endothelial cells Endothelium Immune response Metastasis Animals Disease Progression Endothelium, Vascular Galectins Humans Neoplasms Thijssen, V.L. Rabinovich, G.A. Griffioen, A.W. Vascular galectins: Regulators of tumor progression and targets for cancer therapy |
| topic_facet |
Angiogenesis Endothelial cells Endothelium Immune response Metastasis 6 hydroxilpropylacylfulvene anginex antineoplastic agent bevacizumab ecalectin galectin galectin 1 galectin 10 galectin 12 galectin 13 galectin 14 galectin 2 galectin 3 galectin 4 galectin 7 galectin 8 unclassified drug angiogenesis breast cancer cancer growth cancer therapy cell function drug targeting endothelium cell human immune response metastasis multiple myeloma nonhuman priority journal prostate cancer protein expression regulatory mechanism review tumor escape tumor immunity tumor vascularization Angiogenesis Endothelial cells Endothelium Immune response Metastasis Animals Disease Progression Endothelium, Vascular Galectins Humans Neoplasms |
| description |
Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and growth factor-like functions in multiple steps of cancer progression. They contribute to tumor cell transformation, promote tumor angiogenesis, hamper the anti-tumor immune response, and facilitate tumor metastasis. Consequently, galectins are considered as multifunctional targets for cancer therapy. Interestingly, many of the functions related to tumor progression can be linked to galectins expressed by endothelial cells in the tumor vascular bed. Since the tumor vasculature is an easily accessible target for cancer therapy, understanding how galectins in the tumor endothelium influence cancer progression is important for the translational development of galectin-targeting therapies. © 2013 Elsevier Ltd. |
| format |
JOUR |
| author |
Thijssen, V.L. Rabinovich, G.A. Griffioen, A.W. |
| author_facet |
Thijssen, V.L. Rabinovich, G.A. Griffioen, A.W. |
| author_sort |
Thijssen, V.L. |
| title |
Vascular galectins: Regulators of tumor progression and targets for cancer therapy |
| title_short |
Vascular galectins: Regulators of tumor progression and targets for cancer therapy |
| title_full |
Vascular galectins: Regulators of tumor progression and targets for cancer therapy |
| title_fullStr |
Vascular galectins: Regulators of tumor progression and targets for cancer therapy |
| title_full_unstemmed |
Vascular galectins: Regulators of tumor progression and targets for cancer therapy |
| title_sort |
vascular galectins: regulators of tumor progression and targets for cancer therapy |
| url |
http://hdl.handle.net/20.500.12110/paper_13596101_v24_n6_p547_Thijssen |
| work_keys_str_mv |
AT thijssenvl vasculargalectinsregulatorsoftumorprogressionandtargetsforcancertherapy AT rabinovichga vasculargalectinsregulatorsoftumorprogressionandtargetsforcancertherapy AT griffioenaw vasculargalectinsregulatorsoftumorprogressionandtargetsforcancertherapy |
| _version_ |
1807322774130130944 |