Glucocorticoids in the regulation of transcription factors that control cytokine synthesis

The interaction at different levels between intracellular signals elicited by cytokines and activated glucocorticoid receptors (GR) is essential for the regulation of immune responses. We describe different levels of interaction between glucocorticoids and cytokines which result in the induction or...

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Autores principales:	Liberman, A.C., Druker, J., Perone, M.J., Arzt, E.
Formato:	JOUR
Materias:	Cytokine receptors Cytokines Glucocorticoids Molecular interaction Transcription factors cytokine glucocorticoid glucocorticoid receptor transcription factor article chemical interaction chromatin cross linking cytokine release human immune response molecular dynamics nonhuman priority journal signal transduction Animals Humans Receptors, Glucocorticoid Signal Transduction Transcription Factors Transcription, Genetic
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13596101_v18_n1-2_p45_Liberman
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_13596101_v18_n1-2_p45_Liberman
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spelling	todo:paper_13596101_v18_n1-2_p45_Liberman2023-10-03T16:10:37Z Glucocorticoids in the regulation of transcription factors that control cytokine synthesis Liberman, A.C. Druker, J. Perone, M.J. Arzt, E. Cytokine receptors Cytokines Glucocorticoids Molecular interaction Transcription factors cytokine glucocorticoid glucocorticoid receptor transcription factor article chemical interaction chromatin cross linking cytokine release human immune response molecular dynamics nonhuman priority journal signal transduction Animals Cytokines Glucocorticoids Humans Receptors, Glucocorticoid Signal Transduction Transcription Factors Transcription, Genetic The interaction at different levels between intracellular signals elicited by cytokines and activated glucocorticoid receptors (GR) is essential for the regulation of immune responses. We describe different levels of interaction between glucocorticoids and cytokines which result in the induction or repression of gene transcription. These include the regulation of cytokine receptor expression, the molecular cross-talk between the GR and transcription factors (TFs) activated by cytokine signaling, the interaction with several signaling pathways and also posttranslational modifications of both GR and TFs. Also, an overview of the implications of chromatin remodeling in this interplay is discussed. The complexity of the intricate network involved in the interaction between GR and TFs is pivotal for the final outcome of cytokines biological action. © 2007 Elsevier Ltd. All rights reserved. Fil:Liberman, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Druker, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13596101_v18_n1-2_p45_Liberman
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cytokine receptors Cytokines Glucocorticoids Molecular interaction Transcription factors cytokine glucocorticoid glucocorticoid receptor transcription factor article chemical interaction chromatin cross linking cytokine release human immune response molecular dynamics nonhuman priority journal signal transduction Animals Cytokines Glucocorticoids Humans Receptors, Glucocorticoid Signal Transduction Transcription Factors Transcription, Genetic
spellingShingle	Cytokine receptors Cytokines Glucocorticoids Molecular interaction Transcription factors cytokine glucocorticoid glucocorticoid receptor transcription factor article chemical interaction chromatin cross linking cytokine release human immune response molecular dynamics nonhuman priority journal signal transduction Animals Cytokines Glucocorticoids Humans Receptors, Glucocorticoid Signal Transduction Transcription Factors Transcription, Genetic Liberman, A.C. Druker, J. Perone, M.J. Arzt, E. Glucocorticoids in the regulation of transcription factors that control cytokine synthesis
topic_facet	Cytokine receptors Cytokines Glucocorticoids Molecular interaction Transcription factors cytokine glucocorticoid glucocorticoid receptor transcription factor article chemical interaction chromatin cross linking cytokine release human immune response molecular dynamics nonhuman priority journal signal transduction Animals Cytokines Glucocorticoids Humans Receptors, Glucocorticoid Signal Transduction Transcription Factors Transcription, Genetic
description	The interaction at different levels between intracellular signals elicited by cytokines and activated glucocorticoid receptors (GR) is essential for the regulation of immune responses. We describe different levels of interaction between glucocorticoids and cytokines which result in the induction or repression of gene transcription. These include the regulation of cytokine receptor expression, the molecular cross-talk between the GR and transcription factors (TFs) activated by cytokine signaling, the interaction with several signaling pathways and also posttranslational modifications of both GR and TFs. Also, an overview of the implications of chromatin remodeling in this interplay is discussed. The complexity of the intricate network involved in the interaction between GR and TFs is pivotal for the final outcome of cytokines biological action. © 2007 Elsevier Ltd. All rights reserved.
format	JOUR
author	Liberman, A.C. Druker, J. Perone, M.J. Arzt, E.
author_facet	Liberman, A.C. Druker, J. Perone, M.J. Arzt, E.
author_sort	Liberman, A.C.
title	Glucocorticoids in the regulation of transcription factors that control cytokine synthesis
title_short	Glucocorticoids in the regulation of transcription factors that control cytokine synthesis
title_full	Glucocorticoids in the regulation of transcription factors that control cytokine synthesis
title_fullStr	Glucocorticoids in the regulation of transcription factors that control cytokine synthesis
title_full_unstemmed	Glucocorticoids in the regulation of transcription factors that control cytokine synthesis
title_sort	glucocorticoids in the regulation of transcription factors that control cytokine synthesis
url	http://hdl.handle.net/20.500.12110/paper_13596101_v18_n1-2_p45_Liberman
work_keys_str_mv	AT libermanac glucocorticoidsintheregulationoftranscriptionfactorsthatcontrolcytokinesynthesis AT drukerj glucocorticoidsintheregulationoftranscriptionfactorsthatcontrolcytokinesynthesis AT peronemj glucocorticoidsintheregulationoftranscriptionfactorsthatcontrolcytokinesynthesis AT arzte glucocorticoidsintheregulationoftranscriptionfactorsthatcontrolcytokinesynthesis
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Glucocorticoids in the regulation of transcription factors that control cytokine synthesis

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