Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria

A great deal of information concerning the effects of hexachlorobenzene on the haem metabolic pathway has been obtained but little is known about the effects of the drug on lipid metabolism, Consequently, the time course of phospholipid metabolism alteration caused by this xenobiotic was evaluated a...

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Autores principales:	Billi De Catabbi, S., Sterin-Speziale, N., Fernandez, M.C., Minutolo, C., Aldonatti, C., San Martin De Viale, L.
Formato:	JOUR
Materias:	Hexachlorobenzene Lipid peroxidation Phospholipid Porphyria Porphyrins hexachlorobenzene phospholipid porphyrin uroporphyrinogen decarboxylase animal model article controlled study female lipid peroxidation nonhuman phospholipid metabolism porphyria porphyrin metabolism rat Animals Female Fungicides, Industrial Lipid Metabolism Lipid Peroxidation Porphyrias Rats Rats, Wistar Animalia Rattus norvegicus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13572725_v29_n2_p335_BilliDeCatabbi
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_13572725_v29_n2_p335_BilliDeCatabbi2023-10-03T16:10:26Z Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria Billi De Catabbi, S. Sterin-Speziale, N. Fernandez, M.C. Minutolo, C. Aldonatti, C. San Martin De Viale, L. Hexachlorobenzene Lipid peroxidation Phospholipid Porphyria Porphyrins hexachlorobenzene phospholipid porphyrin uroporphyrinogen decarboxylase animal model article controlled study female lipid peroxidation nonhuman phospholipid metabolism porphyria porphyrin metabolism rat Animals Female Fungicides, Industrial Hexachlorobenzene Lipid Metabolism Lipid Peroxidation Porphyrias Rats Rats, Wistar Animalia Rattus norvegicus A great deal of information concerning the effects of hexachlorobenzene on the haem metabolic pathway has been obtained but little is known about the effects of the drug on lipid metabolism, Consequently, the time course of phospholipid metabolism alteration caused by this xenobiotic was evaluated as related to changes in porphyrin metabolism with the aim to understand better the interregulation of both metabolisms. Female Wistar rats were treated with HCB (1 g/kg) over a 1-8 week period. Individual phospholipid content, [32P] incorporation, total lipid content, lipid peroxidation, uroporphyrinogen decarboxylase activity, its inhibitor generation and porphyrin content, were the parameters measured in the liver of treated rats. Phospholipid metabolism - with the exception of sphingomyelin-presents a biphasic behaviour, in both the endogenous contents and de novo synthesis. The turning point between both phases is the time at which levels of porphyrin and conjugated dienes increase, the latter compounds being involved in oxidative processes. On the other hand, sphingomyelin decreases continuously during the 8 weeks of treatment. It mas also found that the malondialdehyde content increased during the early stages. The time sequence for haem metabolism parameters showed that the accumulation of porphyrins occurs after the decrease in uroporphyrinogen decarboxylase activity and the enzyme inhibitor formation, which are early events (first and second weeks). Porphyrins could not by themselves exacerbate uroporphyrinogen decarboxylase impairment or inhibitor generation. This study shows that hexachlorobenzene alters simultaneously phospholipid and porphyrin metabolisms from the early stages, and generates an oxidative environment that favours porphyrinogens and lipid oxidation at later stages. So, this oxidative environment links the alterations on both metabolisms. Fil:Billi De Catabbi, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Minutolo, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin De Viale, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13572725_v29_n2_p335_BilliDeCatabbi
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Hexachlorobenzene Lipid peroxidation Phospholipid Porphyria Porphyrins hexachlorobenzene phospholipid porphyrin uroporphyrinogen decarboxylase animal model article controlled study female lipid peroxidation nonhuman phospholipid metabolism porphyria porphyrin metabolism rat Animals Female Fungicides, Industrial Hexachlorobenzene Lipid Metabolism Lipid Peroxidation Porphyrias Rats Rats, Wistar Animalia Rattus norvegicus
spellingShingle	Hexachlorobenzene Lipid peroxidation Phospholipid Porphyria Porphyrins hexachlorobenzene phospholipid porphyrin uroporphyrinogen decarboxylase animal model article controlled study female lipid peroxidation nonhuman phospholipid metabolism porphyria porphyrin metabolism rat Animals Female Fungicides, Industrial Hexachlorobenzene Lipid Metabolism Lipid Peroxidation Porphyrias Rats Rats, Wistar Animalia Rattus norvegicus Billi De Catabbi, S. Sterin-Speziale, N. Fernandez, M.C. Minutolo, C. Aldonatti, C. San Martin De Viale, L. Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
topic_facet	Hexachlorobenzene Lipid peroxidation Phospholipid Porphyria Porphyrins hexachlorobenzene phospholipid porphyrin uroporphyrinogen decarboxylase animal model article controlled study female lipid peroxidation nonhuman phospholipid metabolism porphyria porphyrin metabolism rat Animals Female Fungicides, Industrial Hexachlorobenzene Lipid Metabolism Lipid Peroxidation Porphyrias Rats Rats, Wistar Animalia Rattus norvegicus
description	A great deal of information concerning the effects of hexachlorobenzene on the haem metabolic pathway has been obtained but little is known about the effects of the drug on lipid metabolism, Consequently, the time course of phospholipid metabolism alteration caused by this xenobiotic was evaluated as related to changes in porphyrin metabolism with the aim to understand better the interregulation of both metabolisms. Female Wistar rats were treated with HCB (1 g/kg) over a 1-8 week period. Individual phospholipid content, [32P] incorporation, total lipid content, lipid peroxidation, uroporphyrinogen decarboxylase activity, its inhibitor generation and porphyrin content, were the parameters measured in the liver of treated rats. Phospholipid metabolism - with the exception of sphingomyelin-presents a biphasic behaviour, in both the endogenous contents and de novo synthesis. The turning point between both phases is the time at which levels of porphyrin and conjugated dienes increase, the latter compounds being involved in oxidative processes. On the other hand, sphingomyelin decreases continuously during the 8 weeks of treatment. It mas also found that the malondialdehyde content increased during the early stages. The time sequence for haem metabolism parameters showed that the accumulation of porphyrins occurs after the decrease in uroporphyrinogen decarboxylase activity and the enzyme inhibitor formation, which are early events (first and second weeks). Porphyrins could not by themselves exacerbate uroporphyrinogen decarboxylase impairment or inhibitor generation. This study shows that hexachlorobenzene alters simultaneously phospholipid and porphyrin metabolisms from the early stages, and generates an oxidative environment that favours porphyrinogens and lipid oxidation at later stages. So, this oxidative environment links the alterations on both metabolisms.
format	JOUR
author	Billi De Catabbi, S. Sterin-Speziale, N. Fernandez, M.C. Minutolo, C. Aldonatti, C. San Martin De Viale, L.
author_facet	Billi De Catabbi, S. Sterin-Speziale, N. Fernandez, M.C. Minutolo, C. Aldonatti, C. San Martin De Viale, L.
author_sort	Billi De Catabbi, S.
title	Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
title_short	Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
title_full	Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
title_fullStr	Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
title_full_unstemmed	Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
title_sort	time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
url	http://hdl.handle.net/20.500.12110/paper_13572725_v29_n2_p335_BilliDeCatabbi
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Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria

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