Inhibition of Notch signaling attenuates pituitary adenoma growth in Nude mice

Preclinical and clinical studies support that Notch signaling may play an important oncogenic role in cancer, but there is scarce information for pituitary tumors. We therefore undertook a functional study to evaluate Notch participation in pituitary adenoma growth. Tumors generated in Nude mice by...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zubeldía-Brenner, L., De Winne, C., Perrone, S., Rodríguez-Seguí, S.A., Willems, C., Ornstein, A.M., Lacau-Mengido, I., Vankelecom, H., Cristina, C., Becu-Villalobos, D.
Formato: JOUR
Materias:
Angiogenesis
DAPT
GH
Pituitary
Prolactin
growth hormone
messenger RNA
Notch receptor
prolactin
angiogenesis
animal cell
animal experiment
animal model
Article
btg2 gene
cancer inhibition
carcinogenesis
cell migration
cell proliferation
cellular secretion
cnot1 gene
computer model
controlled study
disease association
epigenetics
GH3 cell line
hypophysis adenoma
in vitro study
in vivo study
mouse
mRNA expression level
nonhuman
Notch signaling
nr4a1 gene
rat
transcriptomics
tumor growth
tumor microenvironment
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13510088_v26_n1_p13_ZubeldiaBrenner
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares