Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes

Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is i...

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Autores principales: Rodriguez, M.E., Awruch, J., Dicelio, L.
Formato: JOUR
Materias:
Association constant
Fluorescence quantum yields
Liposomes
PDT
Zinc phthalocyanine
dimyristoylphosphatidylcholine
liposome
photosensitizing agent
phthalocyanine derivative
unclassified drug
zinc derivative
zinc phthalocyaninate
article
binding affinity
chemical structure
drug solubility
fluorescence spectroscopy
lipophilicity
photodynamic therapy
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10884246_v6_n2_p122_Rodriguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_10884246_v6_n2_p122_Rodriguez
record_format dspace
spelling todo:paper_10884246_v6_n2_p122_Rodriguez2023-10-03T16:04:23Z Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes Rodriguez, M.E. Awruch, J. Dicelio, L. Association constant Fluorescence quantum yields Liposomes PDT Zinc phthalocyanine dimyristoylphosphatidylcholine liposome photosensitizing agent phthalocyanine derivative unclassified drug zinc derivative zinc phthalocyaninate article binding affinity chemical structure drug solubility fluorescence spectroscopy lipophilicity photodynamic therapy Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is important to improve their solubility in order to study dyes in solid tumor models. On the other hand, the photodynamic therapy activity depends on the location of phthalocyanines in the cell and the interaction of cellular components. In this work, the photophysical properties of tetrasubstituted Zn(II) phthalocyanines with different lipophilic properties are incorporated into liposomes of L-α-dimyristoylphosphatidylcholine (DMPC). The fluorescence quantum yields, the association constants and their localization in the membranes are reported. Copyright © 2002 Society of Porphyrins & Phthalocyanines. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10884246_v6_n2_p122_Rodriguez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Association constant
Fluorescence quantum yields
Liposomes
PDT
Zinc phthalocyanine
dimyristoylphosphatidylcholine
liposome
photosensitizing agent
phthalocyanine derivative
unclassified drug
zinc derivative
zinc phthalocyaninate
article
binding affinity
chemical structure
drug solubility
fluorescence spectroscopy
lipophilicity
photodynamic therapy
spellingShingle Association constant
Fluorescence quantum yields
Liposomes
PDT
Zinc phthalocyanine
dimyristoylphosphatidylcholine
liposome
photosensitizing agent
phthalocyanine derivative
unclassified drug
zinc derivative
zinc phthalocyaninate
article
binding affinity
chemical structure
drug solubility
fluorescence spectroscopy
lipophilicity
photodynamic therapy
Rodriguez, M.E.
Awruch, J.
Dicelio, L.
Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes
topic_facet Association constant
Fluorescence quantum yields
Liposomes
PDT
Zinc phthalocyanine
dimyristoylphosphatidylcholine
liposome
photosensitizing agent
phthalocyanine derivative
unclassified drug
zinc derivative
zinc phthalocyaninate
article
binding affinity
chemical structure
drug solubility
fluorescence spectroscopy
lipophilicity
photodynamic therapy
description Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is important to improve their solubility in order to study dyes in solid tumor models. On the other hand, the photodynamic therapy activity depends on the location of phthalocyanines in the cell and the interaction of cellular components. In this work, the photophysical properties of tetrasubstituted Zn(II) phthalocyanines with different lipophilic properties are incorporated into liposomes of L-α-dimyristoylphosphatidylcholine (DMPC). The fluorescence quantum yields, the association constants and their localization in the membranes are reported. Copyright © 2002 Society of Porphyrins & Phthalocyanines.
format JOUR
author Rodriguez, M.E.
Awruch, J.
Dicelio, L.
author_facet Rodriguez, M.E.
Awruch, J.
Dicelio, L.
author_sort Rodriguez, M.E.
title Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes
title_short Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes
title_full Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes
title_fullStr Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes
title_full_unstemmed Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes
title_sort photophysical properties of zn(ii) phthalocyaninates incorporated into liposomes
url http://hdl.handle.net/20.500.12110/paper_10884246_v6_n2_p122_Rodriguez
work_keys_str_mv AT rodriguezme photophysicalpropertiesofzniiphthalocyaninatesincorporatedintoliposomes
AT awruchj photophysicalpropertiesofzniiphthalocyaninatesincorporatedintoliposomes
AT diceliol photophysicalpropertiesofzniiphthalocyaninatesincorporatedintoliposomes
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