CYP2D6 polymorphisms in patients with porphyrias

The cytochrome P-450 (CYP) isoenzymes, a superfamily of heme proteins which are the terminal oxidases of the mixed function oxidases system, metabolize more than 70% of all clinically approved drugs. The highly polymorphic CYP2D6 isoform metabolizes more than 25% of most common drugs, and the phenot...

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Detalles Bibliográficos
Autores principales:	Lavandera, J.V., Parera, V.E., Batlle, A., Buzaleh, A.M.
Formato:	JOUR
Materias:	cytochrome P450 2D6 hemoprotein iron isoenzyme oxidoreductase porphyrin derivative adult aged allele Argentina article clinical feature controlled study cytochrome P2D6 gene disease association DNA polymorphism drug exposure drug metabolism enzyme activity enzyme metabolism enzyme regulation female gene genetic analysis genotype phenotype correlation heme synthesis human iron blood level major clinical study male metabolic disorder porphyria priority journal protein family protein function Adolescent Adult Alleles Child Cytochrome P-450 CYP2D6 Female Gene Frequency Genotype Humans Male Middle Aged Phenotype Polymorphism, Genetic Porphyrias
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10761551_v12_n9-10_p259_Lavandera
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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