Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus

An opaque screen moving overhead elicits an escape response in the crab Chasmagnathus that after a few presentations habituates for a long period (long-term habituation, LTH). Previous results suggested that spaced (15 trials separated by 171 s) and massed training (300 trials without rest interval)...

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Detalles Bibliográficos
Autores principales:	Hermitte, G., Pedreira, M.E., Tomsic, D., Maldonado, H.
Formato:	JOUR
Materias:	Crustacea Cycloheximide Habituation Learning Massed and spaced training Protein synthesis cycloheximide animal experiment article conditioning controlled study crab drug effect habituation learning long term memory male memory consolidation nonhuman protein synthesis training
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10747427_v71_n1_p34_Hermitte
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_10747427_v71_n1_p34_Hermitte
record_format	dspace
spelling	todo:paper_10747427_v71_n1_p34_Hermitte2023-10-03T16:03:03Z Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus Hermitte, G. Pedreira, M.E. Tomsic, D. Maldonado, H. Crustacea Cycloheximide Habituation Learning Massed and spaced training Protein synthesis cycloheximide animal experiment article conditioning controlled study crab drug effect habituation learning long term memory male memory consolidation nonhuman protein synthesis training An opaque screen moving overhead elicits an escape response in the crab Chasmagnathus that after a few presentations habituates for a long period (long-term habituation, LTH). Previous results suggested that spaced (15 trials separated by 171 s) and massed training (300 trials without rest interval) were correlated with two different memory components of LTH. The present experiments were aimed at further studying the mechanisms subserving these components. Results indicate that LTH acquired by spaced but not by massed training is blocked either by a training-to-testing context shift or by cycloheximide (15-25 μg) pre- or posttraining injection and that LTH after spaced training persists for longer time (5 days) than after massed training (2 days). A model based on these results that distinguishes two LTH- memory components is proposed: a (context-signal) LTH yielded by spaced training, dependent of context, sensitive to cycloheximide (CYX), and long lasting; and a (signal) LTH yielded by massed training, dependent only on the signal invariance, insensitive to CYX, and shorter lasting. Fil:Hermitte, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10747427_v71_n1_p34_Hermitte
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Crustacea Cycloheximide Habituation Learning Massed and spaced training Protein synthesis cycloheximide animal experiment article conditioning controlled study crab drug effect habituation learning long term memory male memory consolidation nonhuman protein synthesis training
spellingShingle	Crustacea Cycloheximide Habituation Learning Massed and spaced training Protein synthesis cycloheximide animal experiment article conditioning controlled study crab drug effect habituation learning long term memory male memory consolidation nonhuman protein synthesis training Hermitte, G. Pedreira, M.E. Tomsic, D. Maldonado, H. Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus
topic_facet	Crustacea Cycloheximide Habituation Learning Massed and spaced training Protein synthesis cycloheximide animal experiment article conditioning controlled study crab drug effect habituation learning long term memory male memory consolidation nonhuman protein synthesis training
description	An opaque screen moving overhead elicits an escape response in the crab Chasmagnathus that after a few presentations habituates for a long period (long-term habituation, LTH). Previous results suggested that spaced (15 trials separated by 171 s) and massed training (300 trials without rest interval) were correlated with two different memory components of LTH. The present experiments were aimed at further studying the mechanisms subserving these components. Results indicate that LTH acquired by spaced but not by massed training is blocked either by a training-to-testing context shift or by cycloheximide (15-25 μg) pre- or posttraining injection and that LTH after spaced training persists for longer time (5 days) than after massed training (2 days). A model based on these results that distinguishes two LTH- memory components is proposed: a (context-signal) LTH yielded by spaced training, dependent of context, sensitive to cycloheximide (CYX), and long lasting; and a (signal) LTH yielded by massed training, dependent only on the signal invariance, insensitive to CYX, and shorter lasting.
format	JOUR
author	Hermitte, G. Pedreira, M.E. Tomsic, D. Maldonado, H.
author_facet	Hermitte, G. Pedreira, M.E. Tomsic, D. Maldonado, H.
author_sort	Hermitte, G.
title	Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus
title_short	Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus
title_full	Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus
title_fullStr	Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus
title_full_unstemmed	Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus
title_sort	context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab chasmagnathus
url	http://hdl.handle.net/20.500.12110/paper_10747427_v71_n1_p34_Hermitte
work_keys_str_mv	AT hermitteg contextshiftandproteinsynthesisinhibitiondisruptlongtermhabituationafterspacedbutnotmassedtraininginthecrabchasmagnathus AT pedreirame contextshiftandproteinsynthesisinhibitiondisruptlongtermhabituationafterspacedbutnotmassedtraininginthecrabchasmagnathus AT tomsicd contextshiftandproteinsynthesisinhibitiondisruptlongtermhabituationafterspacedbutnotmassedtraininginthecrabchasmagnathus AT maldonadoh contextshiftandproteinsynthesisinhibitiondisruptlongtermhabituationafterspacedbutnotmassedtraininginthecrabchasmagnathus
_version_	1782024360231436288

Context shift and protein synthesis inhibition disrupt long-term habituation after spaced, but not massed, training in the crab Chasmagnathus

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