Correlation between gel structural properties and drug release pattern in scleroglucan matrices

The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4 % in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi...

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Detalles Bibliográficos
Autores principales: Daraio, M.E., François, N., Bernik, D.L.
Formato: JOUR
Materias:
Drug Release
Fluorescent Molecular Probes
Hydrophilic Matrices
Scleroglucan
scleroglucan
theophylline
analytic method
article
chemical model
correlation analysis
drug delivery system
drug release
empiricism
fluorescence analysis
hydrogel
kinetics
mathematical analysis
microenvironment
molecular probe
priority journal
steady state
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10717544_v10_n2_p79_Daraio
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_10717544_v10_n2_p79_Daraio
record_format dspace
spelling todo:paper_10717544_v10_n2_p79_Daraio2023-10-03T16:02:41Z Correlation between gel structural properties and drug release pattern in scleroglucan matrices Daraio, M.E. François, N. Bernik, D.L. Drug Release Fluorescent Molecular Probes Hydrophilic Matrices Scleroglucan scleroglucan theophylline analytic method article chemical model correlation analysis drug delivery system drug release empiricism fluorescence analysis hydrogel kinetics mathematical analysis microenvironment molecular probe priority journal steady state The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4 % in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi-empirical power law equation, finding significant differences between the 0.5% and higher than 0.8% scleroglucan concentrations (w/w). Four molecular fluorescent probes were used to test microenvironmental properties of the gel cavities, which will play a key role on the release of the pharmaceutical drugs. The results found by the fluorescence analysis are in good agreement with the ones obtained by release kinetics. Fil:Daraio, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bernik, D.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10717544_v10_n2_p79_Daraio
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Drug Release
Fluorescent Molecular Probes
Hydrophilic Matrices
Scleroglucan
scleroglucan
theophylline
analytic method
article
chemical model
correlation analysis
drug delivery system
drug release
empiricism
fluorescence analysis
hydrogel
kinetics
mathematical analysis
microenvironment
molecular probe
priority journal
steady state
spellingShingle Drug Release
Fluorescent Molecular Probes
Hydrophilic Matrices
Scleroglucan
scleroglucan
theophylline
analytic method
article
chemical model
correlation analysis
drug delivery system
drug release
empiricism
fluorescence analysis
hydrogel
kinetics
mathematical analysis
microenvironment
molecular probe
priority journal
steady state
Daraio, M.E.
François, N.
Bernik, D.L.
Correlation between gel structural properties and drug release pattern in scleroglucan matrices
topic_facet Drug Release
Fluorescent Molecular Probes
Hydrophilic Matrices
Scleroglucan
scleroglucan
theophylline
analytic method
article
chemical model
correlation analysis
drug delivery system
drug release
empiricism
fluorescence analysis
hydrogel
kinetics
mathematical analysis
microenvironment
molecular probe
priority journal
steady state
description The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4 % in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi-empirical power law equation, finding significant differences between the 0.5% and higher than 0.8% scleroglucan concentrations (w/w). Four molecular fluorescent probes were used to test microenvironmental properties of the gel cavities, which will play a key role on the release of the pharmaceutical drugs. The results found by the fluorescence analysis are in good agreement with the ones obtained by release kinetics.
format JOUR
author Daraio, M.E.
François, N.
Bernik, D.L.
author_facet Daraio, M.E.
François, N.
Bernik, D.L.
author_sort Daraio, M.E.
title Correlation between gel structural properties and drug release pattern in scleroglucan matrices
title_short Correlation between gel structural properties and drug release pattern in scleroglucan matrices
title_full Correlation between gel structural properties and drug release pattern in scleroglucan matrices
title_fullStr Correlation between gel structural properties and drug release pattern in scleroglucan matrices
title_full_unstemmed Correlation between gel structural properties and drug release pattern in scleroglucan matrices
title_sort correlation between gel structural properties and drug release pattern in scleroglucan matrices
url http://hdl.handle.net/20.500.12110/paper_10717544_v10_n2_p79_Daraio
work_keys_str_mv AT daraiome correlationbetweengelstructuralpropertiesanddrugreleasepatterninscleroglucanmatrices
AT francoisn correlationbetweengelstructuralpropertiesanddrugreleasepatterninscleroglucanmatrices
AT bernikdl correlationbetweengelstructuralpropertiesanddrugreleasepatterninscleroglucanmatrices
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