Entry studies of new world arenaviruses
Identification of cell moieties involved in viral binding and internalization is essential since their expression would render a cell susceptible. Further steps that allow the uncoating of the viral particle at the right subcellular localization have been intensively studied. These “entry” steps cou...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_10643745_v1604_n_p113_Martinez |
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todo:paper_10643745_v1604_n_p113_Martinez2023-10-03T16:01:56Z Entry studies of new world arenaviruses Martínez, M.G. Forlenza, M.B. Candurra, N.A. Cordo, S.M. Endocytosis pathways Receptor recognition Virus 3T3 cell line cellular distribution endocytosis genetic transfection host cell Junin virus life cycle Mammarenavirus Moloney murine leukemia virus New World arenavirus nonhuman nucleotide sequence pH tropism Vero cell line virus attachment virus entry virus envelope virus particle virus strain animal Arenaviridae human New World arenavirus pathogenicity physiology Animals Arenaviridae Arenaviruses, New World Endocytosis Humans Identification of cell moieties involved in viral binding and internalization is essential since their expression would render a cell susceptible. Further steps that allow the uncoating of the viral particle at the right subcellular localization have been intensively studied. These “entry” steps could determine cell permissiveness and often define tissue and host tropism. Therefore applying the right and, when possible, straightforward experimental approaches would shorten avenues to the complete knowledge of this first and key step of any viral life cycle. Mammarenaviruses are enveloped viruses that enter the host cell via receptor-mediated endocytosis. In this chapter we present a set of customized experimental approaches and tools that were used to describe the entry of Junín virus (JUNV), and other New World mammarenavirus members, into mammalian cells. © Springer Science+Business Media LLC 2018. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10643745_v1604_n_p113_Martinez |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Endocytosis pathways Receptor recognition Virus 3T3 cell line cellular distribution endocytosis genetic transfection host cell Junin virus life cycle Mammarenavirus Moloney murine leukemia virus New World arenavirus nonhuman nucleotide sequence pH tropism Vero cell line virus attachment virus entry virus envelope virus particle virus strain animal Arenaviridae human New World arenavirus pathogenicity physiology Animals Arenaviridae Arenaviruses, New World Endocytosis Humans |
| spellingShingle |
Endocytosis pathways Receptor recognition Virus 3T3 cell line cellular distribution endocytosis genetic transfection host cell Junin virus life cycle Mammarenavirus Moloney murine leukemia virus New World arenavirus nonhuman nucleotide sequence pH tropism Vero cell line virus attachment virus entry virus envelope virus particle virus strain animal Arenaviridae human New World arenavirus pathogenicity physiology Animals Arenaviridae Arenaviruses, New World Endocytosis Humans Martínez, M.G. Forlenza, M.B. Candurra, N.A. Cordo, S.M. Entry studies of new world arenaviruses |
| topic_facet |
Endocytosis pathways Receptor recognition Virus 3T3 cell line cellular distribution endocytosis genetic transfection host cell Junin virus life cycle Mammarenavirus Moloney murine leukemia virus New World arenavirus nonhuman nucleotide sequence pH tropism Vero cell line virus attachment virus entry virus envelope virus particle virus strain animal Arenaviridae human New World arenavirus pathogenicity physiology Animals Arenaviridae Arenaviruses, New World Endocytosis Humans |
| description |
Identification of cell moieties involved in viral binding and internalization is essential since their expression would render a cell susceptible. Further steps that allow the uncoating of the viral particle at the right subcellular localization have been intensively studied. These “entry” steps could determine cell permissiveness and often define tissue and host tropism. Therefore applying the right and, when possible, straightforward experimental approaches would shorten avenues to the complete knowledge of this first and key step of any viral life cycle. Mammarenaviruses are enveloped viruses that enter the host cell via receptor-mediated endocytosis. In this chapter we present a set of customized experimental approaches and tools that were used to describe the entry of Junín virus (JUNV), and other New World mammarenavirus members, into mammalian cells. © Springer Science+Business Media LLC 2018. |
| format |
SER |
| author |
Martínez, M.G. Forlenza, M.B. Candurra, N.A. Cordo, S.M. |
| author_facet |
Martínez, M.G. Forlenza, M.B. Candurra, N.A. Cordo, S.M. |
| author_sort |
Martínez, M.G. |
| title |
Entry studies of new world arenaviruses |
| title_short |
Entry studies of new world arenaviruses |
| title_full |
Entry studies of new world arenaviruses |
| title_fullStr |
Entry studies of new world arenaviruses |
| title_full_unstemmed |
Entry studies of new world arenaviruses |
| title_sort |
entry studies of new world arenaviruses |
| url |
http://hdl.handle.net/20.500.12110/paper_10643745_v1604_n_p113_Martinez |
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AT martinezmg entrystudiesofnewworldarenaviruses AT forlenzamb entrystudiesofnewworldarenaviruses AT candurrana entrystudiesofnewworldarenaviruses AT cordosm entrystudiesofnewworldarenaviruses |
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