Robustness of the hypoxic response: Another job for miRNAs?

Living organisms are constantly exposed to environmental and genetic perturbations. Biological robustness enables these organisms to maintain their functional stability in the presence of external or internal changes. It has been proposed that microRNAs (miRNAs), small non-coding regulatory RNAs, co...

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Autores principales:	De Lella Ezcurra, A.L., Bertolin, A.P., Melani, M., Wappner, P.
Formato:	JOUR
Materias:	Angiogenesis Hypoxia Hypoxia-inducible factor MicroRNAs Robustness hypoxia inducible factor 1 hypoxia inducible factor 1alpha messenger RNA microRNA RNA induced silencing complex RNA polymerase II 3' untranslated region angiogenesis article biology development gene expression genetic variability human hypoxia negative feedback nonhuman phenotype physiology positive feedback priority journal RNA structure Animals Anoxia Humans Neovascularization, Physiologic Stress, Physiological Transcription Factors
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10588388_v241_n12_p1842_DeLellaEzcurra
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_10588388_v241_n12_p1842_DeLellaEzcurra
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spelling	todo:paper_10588388_v241_n12_p1842_DeLellaEzcurra2023-10-03T16:01:00Z Robustness of the hypoxic response: Another job for miRNAs? De Lella Ezcurra, A.L. Bertolin, A.P. Melani, M. Wappner, P. Angiogenesis Hypoxia Hypoxia-inducible factor MicroRNAs Robustness hypoxia inducible factor 1 hypoxia inducible factor 1alpha messenger RNA microRNA RNA induced silencing complex RNA polymerase II 3' untranslated region angiogenesis article biology development gene expression genetic variability human hypoxia negative feedback nonhuman phenotype physiology positive feedback priority journal RNA structure Animals Anoxia Humans MicroRNAs Neovascularization, Physiologic Stress, Physiological Transcription Factors Living organisms are constantly exposed to environmental and genetic perturbations. Biological robustness enables these organisms to maintain their functional stability in the presence of external or internal changes. It has been proposed that microRNAs (miRNAs), small non-coding regulatory RNAs, contribute to robustness of gene regulatory networks. The hypoxic response is a major and well-characterized example of a cellular and systemic response to environmental stress that needs to be robust. miRNAs regulate the response to hypoxia, both at the level of the main transcription factor that mediates this response, the hypoxia-inducible factor (HIF), and at the level of one of the most important systemic outcomes of the response: angiogenesis. In this review, we will take the hypoxic response as a paradigm of miRNAs participating in circuits that provide robustness to biological responses. © 2012 Wiley Periodicals, Inc. Fil:De Lella Ezcurra, A.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Melani, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Wappner, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10588388_v241_n12_p1842_DeLellaEzcurra
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Angiogenesis Hypoxia Hypoxia-inducible factor MicroRNAs Robustness hypoxia inducible factor 1 hypoxia inducible factor 1alpha messenger RNA microRNA RNA induced silencing complex RNA polymerase II 3' untranslated region angiogenesis article biology development gene expression genetic variability human hypoxia negative feedback nonhuman phenotype physiology positive feedback priority journal RNA structure Animals Anoxia Humans MicroRNAs Neovascularization, Physiologic Stress, Physiological Transcription Factors
spellingShingle	Angiogenesis Hypoxia Hypoxia-inducible factor MicroRNAs Robustness hypoxia inducible factor 1 hypoxia inducible factor 1alpha messenger RNA microRNA RNA induced silencing complex RNA polymerase II 3' untranslated region angiogenesis article biology development gene expression genetic variability human hypoxia negative feedback nonhuman phenotype physiology positive feedback priority journal RNA structure Animals Anoxia Humans MicroRNAs Neovascularization, Physiologic Stress, Physiological Transcription Factors De Lella Ezcurra, A.L. Bertolin, A.P. Melani, M. Wappner, P. Robustness of the hypoxic response: Another job for miRNAs?
topic_facet	Angiogenesis Hypoxia Hypoxia-inducible factor MicroRNAs Robustness hypoxia inducible factor 1 hypoxia inducible factor 1alpha messenger RNA microRNA RNA induced silencing complex RNA polymerase II 3' untranslated region angiogenesis article biology development gene expression genetic variability human hypoxia negative feedback nonhuman phenotype physiology positive feedback priority journal RNA structure Animals Anoxia Humans MicroRNAs Neovascularization, Physiologic Stress, Physiological Transcription Factors
description	Living organisms are constantly exposed to environmental and genetic perturbations. Biological robustness enables these organisms to maintain their functional stability in the presence of external or internal changes. It has been proposed that microRNAs (miRNAs), small non-coding regulatory RNAs, contribute to robustness of gene regulatory networks. The hypoxic response is a major and well-characterized example of a cellular and systemic response to environmental stress that needs to be robust. miRNAs regulate the response to hypoxia, both at the level of the main transcription factor that mediates this response, the hypoxia-inducible factor (HIF), and at the level of one of the most important systemic outcomes of the response: angiogenesis. In this review, we will take the hypoxic response as a paradigm of miRNAs participating in circuits that provide robustness to biological responses. © 2012 Wiley Periodicals, Inc.
format	JOUR
author	De Lella Ezcurra, A.L. Bertolin, A.P. Melani, M. Wappner, P.
author_facet	De Lella Ezcurra, A.L. Bertolin, A.P. Melani, M. Wappner, P.
author_sort	De Lella Ezcurra, A.L.
title	Robustness of the hypoxic response: Another job for miRNAs?
title_short	Robustness of the hypoxic response: Another job for miRNAs?
title_full	Robustness of the hypoxic response: Another job for miRNAs?
title_fullStr	Robustness of the hypoxic response: Another job for miRNAs?
title_full_unstemmed	Robustness of the hypoxic response: Another job for miRNAs?
title_sort	robustness of the hypoxic response: another job for mirnas?
url	http://hdl.handle.net/20.500.12110/paper_10588388_v241_n12_p1842_DeLellaEzcurra
work_keys_str_mv	AT delellaezcurraal robustnessofthehypoxicresponseanotherjobformirnas AT bertolinap robustnessofthehypoxicresponseanotherjobformirnas AT melanim robustnessofthehypoxicresponseanotherjobformirnas AT wappnerp robustnessofthehypoxicresponseanotherjobformirnas
_version_	1782028725920989184

Robustness of the hypoxic response: Another job for miRNAs?

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