Spatial object recognition memory formation under acute stress

Stress is known to have a critical impact on memory processes. In the present work, we focus on the effects of an acute stress event closely associated to an unrelated learning task. Here, we show that acute stress (elevated platform [EP] session) experienced 1 hr after a weak spatial object recogni...

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Autores principales: Lopes da Cunha, P., Villar, M.E., Ballarini, F., Tintorelli, R., Ana María Viola, H.
Formato: INPR
Materias:
elevated platform
hippocampus
long-term memory
spatial object recognition
synaptic tagging
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10509631_v_n_p_LopesdaCunha
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_10509631_v_n_p_LopesdaCunha
record_format dspace
spelling todo:paper_10509631_v_n_p_LopesdaCunha2023-10-03T16:00:30Z Spatial object recognition memory formation under acute stress Lopes da Cunha, P. Villar, M.E. Ballarini, F. Tintorelli, R. Ana María Viola, H. elevated platform hippocampus long-term memory spatial object recognition synaptic tagging Stress is known to have a critical impact on memory processes. In the present work, we focus on the effects of an acute stress event closely associated to an unrelated learning task. Here, we show that acute stress (elevated platform [EP] session) experienced 1 hr after a weak spatial object recognition (SOR) training, which only induces a short-term memory (STM), promoted the formation of SOR-long term memory (SOR-LTM) in rats. The effect induced by stress was dependent on the activation of glucocorticoid- and mineralocorticoid-receptors, brain-derived neurotrophic factor (BDNF) and protein synthesis in the dorsal hippocampus. In contrast, EP after a strong SOR impaired SOR-LTM probably by interfering with the use of necessary resources. Moreover, we show that the EP session before training induced anterograde interference, which it was not reversed by a subsequent exposure to an open field. Our findings provide novel insights into the impact of stress on LTM formation in rodents and they are discussed under the behavioral analogue of the synaptic tagging and capture hypothesis. © 2018 Wiley Periodicals, Inc. INPR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10509631_v_n_p_LopesdaCunha
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic elevated platform
hippocampus
long-term memory
spatial object recognition
synaptic tagging
spellingShingle elevated platform
hippocampus
long-term memory
spatial object recognition
synaptic tagging
Lopes da Cunha, P.
Villar, M.E.
Ballarini, F.
Tintorelli, R.
Ana María Viola, H.
Spatial object recognition memory formation under acute stress
topic_facet elevated platform
hippocampus
long-term memory
spatial object recognition
synaptic tagging
description Stress is known to have a critical impact on memory processes. In the present work, we focus on the effects of an acute stress event closely associated to an unrelated learning task. Here, we show that acute stress (elevated platform [EP] session) experienced 1 hr after a weak spatial object recognition (SOR) training, which only induces a short-term memory (STM), promoted the formation of SOR-long term memory (SOR-LTM) in rats. The effect induced by stress was dependent on the activation of glucocorticoid- and mineralocorticoid-receptors, brain-derived neurotrophic factor (BDNF) and protein synthesis in the dorsal hippocampus. In contrast, EP after a strong SOR impaired SOR-LTM probably by interfering with the use of necessary resources. Moreover, we show that the EP session before training induced anterograde interference, which it was not reversed by a subsequent exposure to an open field. Our findings provide novel insights into the impact of stress on LTM formation in rodents and they are discussed under the behavioral analogue of the synaptic tagging and capture hypothesis. © 2018 Wiley Periodicals, Inc.
format INPR
author Lopes da Cunha, P.
Villar, M.E.
Ballarini, F.
Tintorelli, R.
Ana María Viola, H.
author_facet Lopes da Cunha, P.
Villar, M.E.
Ballarini, F.
Tintorelli, R.
Ana María Viola, H.
author_sort Lopes da Cunha, P.
title Spatial object recognition memory formation under acute stress
title_short Spatial object recognition memory formation under acute stress
title_full Spatial object recognition memory formation under acute stress
title_fullStr Spatial object recognition memory formation under acute stress
title_full_unstemmed Spatial object recognition memory formation under acute stress
title_sort spatial object recognition memory formation under acute stress
url http://hdl.handle.net/20.500.12110/paper_10509631_v_n_p_LopesdaCunha
work_keys_str_mv AT lopesdacunhap spatialobjectrecognitionmemoryformationunderacutestress
AT villarme spatialobjectrecognitionmemoryformationunderacutestress
AT ballarinif spatialobjectrecognitionmemoryformationunderacutestress
AT tintorellir spatialobjectrecognitionmemoryformationunderacutestress
AT anamariaviolah spatialobjectrecognitionmemoryformationunderacutestress
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