Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens

Problem Fetal implantation enhances the production of essential growth factors such as LIF (leukaemia inhibitory factor), hence we investigated the contribution of maternal CD4 cells, activated by paternal or trophoblast antigens and its modulation by VIP (vasoactive intestinal peptide) and progeste...

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Autores principales: Fraccaroli, L., Grasso, E., Zeitler, E., Lombardi, E., Gogorza, S., Etchepareborda, J.J., Nagle, C., Cortelezzi, M., Leirós, C.P., Ramhorst, R.
Formato: JOUR
Materias:
Chemokines
Recurrent spontaneous abortions
Tolerance and pregnancy
antigen
gelatinase B
leukemia inhibitory factor
progesterone
STAT3 protein
vasoactive intestinal polypeptide
article
CD4+ T lymphocyte
cell stimulation
controlled study
enzyme activity
female
female fertility
fetoplacental unit
human
human cell
inflammation
lymphocytic infiltration
nidation
peripheral blood mononuclear cell
priority journal
protein synthesis
recurrent abortion
spontaneous abortion
T lymphocyte
trophoblast
Abortion, Habitual
Antigens
CD4-Positive T-Lymphocytes
Cells, Cultured
Coculture Techniques
Embryo Implantation
Female
Humans
Immune Tolerance
Leukemia Inhibitory Factor
Leukocytes, Mononuclear
Male
Pregnancy
Progesterone
Trophoblasts
Vasoactive Intestinal Peptide
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10467408_v65_n2_p133_Fraccaroli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_10467408_v65_n2_p133_Fraccaroli
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spelling todo:paper_10467408_v65_n2_p133_Fraccaroli2023-10-03T15:58:29Z Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens Fraccaroli, L. Grasso, E. Zeitler, E. Lombardi, E. Gogorza, S. Etchepareborda, J.J. Nagle, C. Cortelezzi, M. Leirós, C.P. Ramhorst, R. Chemokines Recurrent spontaneous abortions Tolerance and pregnancy antigen gelatinase B leukemia inhibitory factor progesterone STAT3 protein vasoactive intestinal polypeptide article CD4+ T lymphocyte cell stimulation controlled study enzyme activity female female fertility fetoplacental unit human human cell inflammation lymphocytic infiltration nidation peripheral blood mononuclear cell priority journal protein synthesis recurrent abortion spontaneous abortion T lymphocyte trophoblast Abortion, Habitual Antigens CD4-Positive T-Lymphocytes Cells, Cultured Coculture Techniques Embryo Implantation Female Humans Immune Tolerance Leukemia Inhibitory Factor Leukocytes, Mononuclear Male Pregnancy Progesterone Trophoblasts Vasoactive Intestinal Peptide Problem Fetal implantation enhances the production of essential growth factors such as LIF (leukaemia inhibitory factor), hence we investigated the contribution of maternal CD4 cells, activated by paternal or trophoblast antigens and its modulation by VIP (vasoactive intestinal peptide) and progesterone.Method of study We performed co cultures of trophoblast cells (Swan 71 cell line) or paternal antigens and PBMCs from patients with recurrent spontaneous abortions (RSA) and fertile women.Result Fertile-CD4+LIF+ cells were increased by VIP and progesterone in response to paternal and trophoblast antigens. Also MMP 9 activity was decreased and pSTAT3/STAT3 ratio was increased. RSA patients have decreased levels of LIF expression which could not be modulated by VIP and progesterone and displayed a reduced number of endometrial infiltrated CD4+LIF+ cells compared with fertile women.Conclusion The decrease of CD4+LIF+ cells in RSA patients could be related with the exacerbated inflammatory response observed in the maternal fetal dialogue model. © 2010 John Wiley & Sons A/S. Fil:Fraccaroli, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Grasso, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Leirós, C.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramhorst, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10467408_v65_n2_p133_Fraccaroli
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Chemokines
Recurrent spontaneous abortions
Tolerance and pregnancy
antigen
gelatinase B
leukemia inhibitory factor
progesterone
STAT3 protein
vasoactive intestinal polypeptide
article
CD4+ T lymphocyte
cell stimulation
controlled study
enzyme activity
female
female fertility
fetoplacental unit
human
human cell
inflammation
lymphocytic infiltration
nidation
peripheral blood mononuclear cell
priority journal
protein synthesis
recurrent abortion
spontaneous abortion
T lymphocyte
trophoblast
Abortion, Habitual
Antigens
CD4-Positive T-Lymphocytes
Cells, Cultured
Coculture Techniques
Embryo Implantation
Female
Humans
Immune Tolerance
Leukemia Inhibitory Factor
Leukocytes, Mononuclear
Male
Pregnancy
Progesterone
Trophoblasts
Vasoactive Intestinal Peptide
spellingShingle Chemokines
Recurrent spontaneous abortions
Tolerance and pregnancy
antigen
gelatinase B
leukemia inhibitory factor
progesterone
STAT3 protein
vasoactive intestinal polypeptide
article
CD4+ T lymphocyte
cell stimulation
controlled study
enzyme activity
female
female fertility
fetoplacental unit
human
human cell
inflammation
lymphocytic infiltration
nidation
peripheral blood mononuclear cell
priority journal
protein synthesis
recurrent abortion
spontaneous abortion
T lymphocyte
trophoblast
Abortion, Habitual
Antigens
CD4-Positive T-Lymphocytes
Cells, Cultured
Coculture Techniques
Embryo Implantation
Female
Humans
Immune Tolerance
Leukemia Inhibitory Factor
Leukocytes, Mononuclear
Male
Pregnancy
Progesterone
Trophoblasts
Vasoactive Intestinal Peptide
Fraccaroli, L.
Grasso, E.
Zeitler, E.
Lombardi, E.
Gogorza, S.
Etchepareborda, J.J.
Nagle, C.
Cortelezzi, M.
Leirós, C.P.
Ramhorst, R.
Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
topic_facet Chemokines
Recurrent spontaneous abortions
Tolerance and pregnancy
antigen
gelatinase B
leukemia inhibitory factor
progesterone
STAT3 protein
vasoactive intestinal polypeptide
article
CD4+ T lymphocyte
cell stimulation
controlled study
enzyme activity
female
female fertility
fetoplacental unit
human
human cell
inflammation
lymphocytic infiltration
nidation
peripheral blood mononuclear cell
priority journal
protein synthesis
recurrent abortion
spontaneous abortion
T lymphocyte
trophoblast
Abortion, Habitual
Antigens
CD4-Positive T-Lymphocytes
Cells, Cultured
Coculture Techniques
Embryo Implantation
Female
Humans
Immune Tolerance
Leukemia Inhibitory Factor
Leukocytes, Mononuclear
Male
Pregnancy
Progesterone
Trophoblasts
Vasoactive Intestinal Peptide
description Problem Fetal implantation enhances the production of essential growth factors such as LIF (leukaemia inhibitory factor), hence we investigated the contribution of maternal CD4 cells, activated by paternal or trophoblast antigens and its modulation by VIP (vasoactive intestinal peptide) and progesterone.Method of study We performed co cultures of trophoblast cells (Swan 71 cell line) or paternal antigens and PBMCs from patients with recurrent spontaneous abortions (RSA) and fertile women.Result Fertile-CD4+LIF+ cells were increased by VIP and progesterone in response to paternal and trophoblast antigens. Also MMP 9 activity was decreased and pSTAT3/STAT3 ratio was increased. RSA patients have decreased levels of LIF expression which could not be modulated by VIP and progesterone and displayed a reduced number of endometrial infiltrated CD4+LIF+ cells compared with fertile women.Conclusion The decrease of CD4+LIF+ cells in RSA patients could be related with the exacerbated inflammatory response observed in the maternal fetal dialogue model. © 2010 John Wiley & Sons A/S.
format JOUR
author Fraccaroli, L.
Grasso, E.
Zeitler, E.
Lombardi, E.
Gogorza, S.
Etchepareborda, J.J.
Nagle, C.
Cortelezzi, M.
Leirós, C.P.
Ramhorst, R.
author_facet Fraccaroli, L.
Grasso, E.
Zeitler, E.
Lombardi, E.
Gogorza, S.
Etchepareborda, J.J.
Nagle, C.
Cortelezzi, M.
Leirós, C.P.
Ramhorst, R.
author_sort Fraccaroli, L.
title Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_short Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_full Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_fullStr Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_full_unstemmed Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_sort modulation of maternal lif producers t cells by trophoblast and paternal antigens
url http://hdl.handle.net/20.500.12110/paper_10467408_v65_n2_p133_Fraccaroli
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