Peripheral and central inflammation in autism spectrum disorders
Recent reports have given a central role to environmental factors in the etiology of autism spectrum disorders (ASD). However, most proposed perinatal factors seem to converge into the activation of the immune system, suggesting that an early inflammatory response could be a unifying factor in the e...
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todo:paper_10447431_v53_n_p69_Depino2023-10-03T15:58:18Z Peripheral and central inflammation in autism spectrum disorders Depino, A.M. Animal model Autism spectrum disorders Behavior Cytokines Immune activation Inflammation alpha interferon autoantibody chemokine cytokine gamma interferon interleukin 1 interleukin 1 receptor interleukin 10 interleukin 1beta interleukin 2 interleukin 4 interleukin 6 interleukin 8 monocyte chemotactic protein 1 myelin transforming growth factor beta1 tumor necrosis factor alpha adulthood article astrocytosis autism autoimmune disease bacterial infection behavior brain development cell migration central nervous system chronic inflammation cytokine production cytokine response disease association environmental factor epigenetic repression fetus development gestational age glia cell heredity hippocampus human immune response immunity immunocompetent cell molecular mechanics nerve cell nerve cell differentiation nerve degeneration nervous system inflammation neuropsychiatry nonhuman pathophysiology perinatal period peripheral nervous system postnatal development prenatal period priority journal protein expression Streptococcus infection systemic lupus erythematosus virus infection Animals Child Child Development Disorders, Pervasive Cytokines Humans Immunity, Maternally-Acquired Inflammation Animalia Rodentia Recent reports have given a central role to environmental factors in the etiology of autism spectrum disorders (ASD). However, most proposed perinatal factors seem to converge into the activation of the immune system, suggesting that an early inflammatory response could be a unifying factor in the etiology ASD. Here I review the evidence of early immune activation in individuals with ASD, and the chronic peripheral and central alterations observed in the inflammatory response in ASD. This evidence shows that ASD is associated with altered neuroinflammatory processes and abnormal immune responses in adulthood. How these immune alterations can affect developmental programming of adult behavior or directly affect behavior later in life is discussed in the context of both clinical and animal models of research. Recent studies in rodents clearly support a role of elevated cytokines in the behavioral symptoms of ASD, both during development and in adulthood. This article is part of a Special Issue entitled 'Neuroinflammation in neurodegeneration and neurodysfunction'. © 2012 Elsevier Inc. Fil:Depino, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10447431_v53_n_p69_Depino |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Animal model Autism spectrum disorders Behavior Cytokines Immune activation Inflammation alpha interferon autoantibody chemokine cytokine gamma interferon interleukin 1 interleukin 1 receptor interleukin 10 interleukin 1beta interleukin 2 interleukin 4 interleukin 6 interleukin 8 monocyte chemotactic protein 1 myelin transforming growth factor beta1 tumor necrosis factor alpha adulthood article astrocytosis autism autoimmune disease bacterial infection behavior brain development cell migration central nervous system chronic inflammation cytokine production cytokine response disease association environmental factor epigenetic repression fetus development gestational age glia cell heredity hippocampus human immune response immunity immunocompetent cell molecular mechanics nerve cell nerve cell differentiation nerve degeneration nervous system inflammation neuropsychiatry nonhuman pathophysiology perinatal period peripheral nervous system postnatal development prenatal period priority journal protein expression Streptococcus infection systemic lupus erythematosus virus infection Animals Child Child Development Disorders, Pervasive Cytokines Humans Immunity, Maternally-Acquired Inflammation Animalia Rodentia |
| spellingShingle |
Animal model Autism spectrum disorders Behavior Cytokines Immune activation Inflammation alpha interferon autoantibody chemokine cytokine gamma interferon interleukin 1 interleukin 1 receptor interleukin 10 interleukin 1beta interleukin 2 interleukin 4 interleukin 6 interleukin 8 monocyte chemotactic protein 1 myelin transforming growth factor beta1 tumor necrosis factor alpha adulthood article astrocytosis autism autoimmune disease bacterial infection behavior brain development cell migration central nervous system chronic inflammation cytokine production cytokine response disease association environmental factor epigenetic repression fetus development gestational age glia cell heredity hippocampus human immune response immunity immunocompetent cell molecular mechanics nerve cell nerve cell differentiation nerve degeneration nervous system inflammation neuropsychiatry nonhuman pathophysiology perinatal period peripheral nervous system postnatal development prenatal period priority journal protein expression Streptococcus infection systemic lupus erythematosus virus infection Animals Child Child Development Disorders, Pervasive Cytokines Humans Immunity, Maternally-Acquired Inflammation Animalia Rodentia Depino, A.M. Peripheral and central inflammation in autism spectrum disorders |
| topic_facet |
Animal model Autism spectrum disorders Behavior Cytokines Immune activation Inflammation alpha interferon autoantibody chemokine cytokine gamma interferon interleukin 1 interleukin 1 receptor interleukin 10 interleukin 1beta interleukin 2 interleukin 4 interleukin 6 interleukin 8 monocyte chemotactic protein 1 myelin transforming growth factor beta1 tumor necrosis factor alpha adulthood article astrocytosis autism autoimmune disease bacterial infection behavior brain development cell migration central nervous system chronic inflammation cytokine production cytokine response disease association environmental factor epigenetic repression fetus development gestational age glia cell heredity hippocampus human immune response immunity immunocompetent cell molecular mechanics nerve cell nerve cell differentiation nerve degeneration nervous system inflammation neuropsychiatry nonhuman pathophysiology perinatal period peripheral nervous system postnatal development prenatal period priority journal protein expression Streptococcus infection systemic lupus erythematosus virus infection Animals Child Child Development Disorders, Pervasive Cytokines Humans Immunity, Maternally-Acquired Inflammation Animalia Rodentia |
| description |
Recent reports have given a central role to environmental factors in the etiology of autism spectrum disorders (ASD). However, most proposed perinatal factors seem to converge into the activation of the immune system, suggesting that an early inflammatory response could be a unifying factor in the etiology ASD. Here I review the evidence of early immune activation in individuals with ASD, and the chronic peripheral and central alterations observed in the inflammatory response in ASD. This evidence shows that ASD is associated with altered neuroinflammatory processes and abnormal immune responses in adulthood. How these immune alterations can affect developmental programming of adult behavior or directly affect behavior later in life is discussed in the context of both clinical and animal models of research. Recent studies in rodents clearly support a role of elevated cytokines in the behavioral symptoms of ASD, both during development and in adulthood. This article is part of a Special Issue entitled 'Neuroinflammation in neurodegeneration and neurodysfunction'. © 2012 Elsevier Inc. |
| format |
JOUR |
| author |
Depino, A.M. |
| author_facet |
Depino, A.M. |
| author_sort |
Depino, A.M. |
| title |
Peripheral and central inflammation in autism spectrum disorders |
| title_short |
Peripheral and central inflammation in autism spectrum disorders |
| title_full |
Peripheral and central inflammation in autism spectrum disorders |
| title_fullStr |
Peripheral and central inflammation in autism spectrum disorders |
| title_full_unstemmed |
Peripheral and central inflammation in autism spectrum disorders |
| title_sort |
peripheral and central inflammation in autism spectrum disorders |
| url |
http://hdl.handle.net/20.500.12110/paper_10447431_v53_n_p69_Depino |
| work_keys_str_mv |
AT depinoam peripheralandcentralinflammationinautismspectrumdisorders |
| _version_ |
1807319181943635968 |