Neuroprotective actions of estradiol revisited
Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understanding of the complex signaling of estradiol in neural c...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_10432760_v22_n12_p467_Azcoitia |
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todo:paper_10432760_v22_n12_p467_Azcoitia2023-10-03T15:58:12Z Neuroprotective actions of estradiol revisited Azcoitia, I. Arevalo, M.-A. De Nicola, A.F. Garcia-Segura, L.M. aromatase inhibitor conjugated estrogen contraceptive agent estradiol estrogen estrogen receptor alpha estrogen receptor beta gestagen medroxyprogesterone acetate neuroglobin progesterone seladin 1 selective estrogen receptor modulator somatomedin C somatomedin C receptor unclassified drug Wnt protein Alzheimer disease antiinflammatory activity brain function brain ischemia brain mitochondrion brain nerve cell cancer risk central nervous system cognition cytoplasm dementia demyelinating disease endometrium cancer estrogen activity estrogen synthesis high risk population hormonal therapy human hypertension mitochondrial genome multiple sclerosis nerve cell membrane nervous system development neuroprotection nonhuman Parkinson disease postmenopause priority journal review risk reduction signal transduction species difference stroke traumatic brain injury Aging Animals Estradiol Estrogen Replacement Therapy Female Humans Male Neuroglia Neurons Neuroprotective Agents Neurotoxicity Syndromes Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understanding of the complex signaling of estradiol in neural cells has recently clarified the causes of this discrepancy. New data indicate that estradiol may lose its neuroprotective activity or even increase neural damage, a situation that depends on the duration of ovarian hormone deprivation and on age-associated modifications in the levels of other molecules that modulate estradiol action. These studies highlight the complex neuroprotective mechanisms of estradiol and suggest a window of opportunity during which effective hormonal therapy could promote brain function and cognition. © 2011 Elsevier Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10432760_v22_n12_p467_Azcoitia |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
aromatase inhibitor conjugated estrogen contraceptive agent estradiol estrogen estrogen receptor alpha estrogen receptor beta gestagen medroxyprogesterone acetate neuroglobin progesterone seladin 1 selective estrogen receptor modulator somatomedin C somatomedin C receptor unclassified drug Wnt protein Alzheimer disease antiinflammatory activity brain function brain ischemia brain mitochondrion brain nerve cell cancer risk central nervous system cognition cytoplasm dementia demyelinating disease endometrium cancer estrogen activity estrogen synthesis high risk population hormonal therapy human hypertension mitochondrial genome multiple sclerosis nerve cell membrane nervous system development neuroprotection nonhuman Parkinson disease postmenopause priority journal review risk reduction signal transduction species difference stroke traumatic brain injury Aging Animals Estradiol Estrogen Replacement Therapy Female Humans Male Neuroglia Neurons Neuroprotective Agents Neurotoxicity Syndromes |
| spellingShingle |
aromatase inhibitor conjugated estrogen contraceptive agent estradiol estrogen estrogen receptor alpha estrogen receptor beta gestagen medroxyprogesterone acetate neuroglobin progesterone seladin 1 selective estrogen receptor modulator somatomedin C somatomedin C receptor unclassified drug Wnt protein Alzheimer disease antiinflammatory activity brain function brain ischemia brain mitochondrion brain nerve cell cancer risk central nervous system cognition cytoplasm dementia demyelinating disease endometrium cancer estrogen activity estrogen synthesis high risk population hormonal therapy human hypertension mitochondrial genome multiple sclerosis nerve cell membrane nervous system development neuroprotection nonhuman Parkinson disease postmenopause priority journal review risk reduction signal transduction species difference stroke traumatic brain injury Aging Animals Estradiol Estrogen Replacement Therapy Female Humans Male Neuroglia Neurons Neuroprotective Agents Neurotoxicity Syndromes Azcoitia, I. Arevalo, M.-A. De Nicola, A.F. Garcia-Segura, L.M. Neuroprotective actions of estradiol revisited |
| topic_facet |
aromatase inhibitor conjugated estrogen contraceptive agent estradiol estrogen estrogen receptor alpha estrogen receptor beta gestagen medroxyprogesterone acetate neuroglobin progesterone seladin 1 selective estrogen receptor modulator somatomedin C somatomedin C receptor unclassified drug Wnt protein Alzheimer disease antiinflammatory activity brain function brain ischemia brain mitochondrion brain nerve cell cancer risk central nervous system cognition cytoplasm dementia demyelinating disease endometrium cancer estrogen activity estrogen synthesis high risk population hormonal therapy human hypertension mitochondrial genome multiple sclerosis nerve cell membrane nervous system development neuroprotection nonhuman Parkinson disease postmenopause priority journal review risk reduction signal transduction species difference stroke traumatic brain injury Aging Animals Estradiol Estrogen Replacement Therapy Female Humans Male Neuroglia Neurons Neuroprotective Agents Neurotoxicity Syndromes |
| description |
Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understanding of the complex signaling of estradiol in neural cells has recently clarified the causes of this discrepancy. New data indicate that estradiol may lose its neuroprotective activity or even increase neural damage, a situation that depends on the duration of ovarian hormone deprivation and on age-associated modifications in the levels of other molecules that modulate estradiol action. These studies highlight the complex neuroprotective mechanisms of estradiol and suggest a window of opportunity during which effective hormonal therapy could promote brain function and cognition. © 2011 Elsevier Ltd. |
| format |
JOUR |
| author |
Azcoitia, I. Arevalo, M.-A. De Nicola, A.F. Garcia-Segura, L.M. |
| author_facet |
Azcoitia, I. Arevalo, M.-A. De Nicola, A.F. Garcia-Segura, L.M. |
| author_sort |
Azcoitia, I. |
| title |
Neuroprotective actions of estradiol revisited |
| title_short |
Neuroprotective actions of estradiol revisited |
| title_full |
Neuroprotective actions of estradiol revisited |
| title_fullStr |
Neuroprotective actions of estradiol revisited |
| title_full_unstemmed |
Neuroprotective actions of estradiol revisited |
| title_sort |
neuroprotective actions of estradiol revisited |
| url |
http://hdl.handle.net/20.500.12110/paper_10432760_v22_n12_p467_Azcoitia |
| work_keys_str_mv |
AT azcoitiai neuroprotectiveactionsofestradiolrevisited AT arevaloma neuroprotectiveactionsofestradiolrevisited AT denicolaaf neuroprotectiveactionsofestradiolrevisited AT garciaseguralm neuroprotectiveactionsofestradiolrevisited |
| _version_ |
1807320204548505600 |