Effect of α lipoic acid amide on hexachlorobenzene porphyria
The aim of this work is to study the effect of thioctamide - the commercial form of a lipoic acid amide - on the porphyrinogenic action of hexachlorobenzene (HCB). For this purpose, porphyria was induced in rats by chronic HCB treatment, with or without simultaneous thioctamide administration. Two d...
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todo:paper_10399712_v47_n5_p815_Vilas2023-10-03T15:57:38Z Effect of α lipoic acid amide on hexachlorobenzene porphyria Vilas, G.L. Aldonatti, C. San Martín De Viale, L.C. Del Ríos De Molina, M.C. α lipoic acid Free radical scavenger Hexachlorobenzene Lipid peroxidation Porphyria Thioctamide Uroporphyrinogen decarboxylase 5 aminolevulinate synthase amide aminolevulinic acid hexachlorobenzene porphobilinogen porphyrin scavenger thiobarbituric acid reactive substance thioctic acid uroporphyrin uroporphyrinogen decarboxylase animal experiment animal model article bioaccumulation controlled study enzyme activity excretion female liver nonhuman porphyria rat urine level Animals Female Free Radical Scavengers Hexachlorobenzene Porphyrias Rats Rats, Wistar Thioctic Acid Time Factors Animalia The aim of this work is to study the effect of thioctamide - the commercial form of a lipoic acid amide - on the porphyrinogenic action of hexachlorobenzene (HCB). For this purpose, porphyria was induced in rats by chronic HCB treatment, with or without simultaneous thioctamide administration. Two different groups of rats were used as reference: one treated with vehicle (control) and the other treated with thioctamide (TO). Urine δ aminolevulic acid, porphobilinogen, and porphyrin excretions were lower in the HCB + TO treated group than in the HCB group, and the same happened with liver uroporphyrin accumulation. On the other hand, the second stage of uroporphyrinogen-decarboxylase activity was significantly higher in the HCB + TO group than in the HCB group. δ aminolevulic acid synthase activity was higher in the HCB group. Hepatic thiobarbituric acid reactive substances were lower in HCB + TO group than in HCB group. Thus, we might suggest that TO would decrease HCB effects by means of its free radical scavenging ability, and by having a direct effect on uroporphyrinogen-decarboxylase activity. Fil:Vilas, G.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martín De Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Ríos De Molina, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10399712_v47_n5_p815_Vilas |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
α lipoic acid Free radical scavenger Hexachlorobenzene Lipid peroxidation Porphyria Thioctamide Uroporphyrinogen decarboxylase 5 aminolevulinate synthase amide aminolevulinic acid hexachlorobenzene porphobilinogen porphyrin scavenger thiobarbituric acid reactive substance thioctic acid uroporphyrin uroporphyrinogen decarboxylase animal experiment animal model article bioaccumulation controlled study enzyme activity excretion female liver nonhuman porphyria rat urine level Animals Female Free Radical Scavengers Hexachlorobenzene Porphyrias Rats Rats, Wistar Thioctic Acid Time Factors Animalia |
| spellingShingle |
α lipoic acid Free radical scavenger Hexachlorobenzene Lipid peroxidation Porphyria Thioctamide Uroporphyrinogen decarboxylase 5 aminolevulinate synthase amide aminolevulinic acid hexachlorobenzene porphobilinogen porphyrin scavenger thiobarbituric acid reactive substance thioctic acid uroporphyrin uroporphyrinogen decarboxylase animal experiment animal model article bioaccumulation controlled study enzyme activity excretion female liver nonhuman porphyria rat urine level Animals Female Free Radical Scavengers Hexachlorobenzene Porphyrias Rats Rats, Wistar Thioctic Acid Time Factors Animalia Vilas, G.L. Aldonatti, C. San Martín De Viale, L.C. Del Ríos De Molina, M.C. Effect of α lipoic acid amide on hexachlorobenzene porphyria |
| topic_facet |
α lipoic acid Free radical scavenger Hexachlorobenzene Lipid peroxidation Porphyria Thioctamide Uroporphyrinogen decarboxylase 5 aminolevulinate synthase amide aminolevulinic acid hexachlorobenzene porphobilinogen porphyrin scavenger thiobarbituric acid reactive substance thioctic acid uroporphyrin uroporphyrinogen decarboxylase animal experiment animal model article bioaccumulation controlled study enzyme activity excretion female liver nonhuman porphyria rat urine level Animals Female Free Radical Scavengers Hexachlorobenzene Porphyrias Rats Rats, Wistar Thioctic Acid Time Factors Animalia |
| description |
The aim of this work is to study the effect of thioctamide - the commercial form of a lipoic acid amide - on the porphyrinogenic action of hexachlorobenzene (HCB). For this purpose, porphyria was induced in rats by chronic HCB treatment, with or without simultaneous thioctamide administration. Two different groups of rats were used as reference: one treated with vehicle (control) and the other treated with thioctamide (TO). Urine δ aminolevulic acid, porphobilinogen, and porphyrin excretions were lower in the HCB + TO treated group than in the HCB group, and the same happened with liver uroporphyrin accumulation. On the other hand, the second stage of uroporphyrinogen-decarboxylase activity was significantly higher in the HCB + TO group than in the HCB group. δ aminolevulic acid synthase activity was higher in the HCB group. Hepatic thiobarbituric acid reactive substances were lower in HCB + TO group than in HCB group. Thus, we might suggest that TO would decrease HCB effects by means of its free radical scavenging ability, and by having a direct effect on uroporphyrinogen-decarboxylase activity. |
| format |
JOUR |
| author |
Vilas, G.L. Aldonatti, C. San Martín De Viale, L.C. Del Ríos De Molina, M.C. |
| author_facet |
Vilas, G.L. Aldonatti, C. San Martín De Viale, L.C. Del Ríos De Molina, M.C. |
| author_sort |
Vilas, G.L. |
| title |
Effect of α lipoic acid amide on hexachlorobenzene porphyria |
| title_short |
Effect of α lipoic acid amide on hexachlorobenzene porphyria |
| title_full |
Effect of α lipoic acid amide on hexachlorobenzene porphyria |
| title_fullStr |
Effect of α lipoic acid amide on hexachlorobenzene porphyria |
| title_full_unstemmed |
Effect of α lipoic acid amide on hexachlorobenzene porphyria |
| title_sort |
effect of α lipoic acid amide on hexachlorobenzene porphyria |
| url |
http://hdl.handle.net/20.500.12110/paper_10399712_v47_n5_p815_Vilas |
| work_keys_str_mv |
AT vilasgl effectofalipoicacidamideonhexachlorobenzeneporphyria AT aldonattic effectofalipoicacidamideonhexachlorobenzeneporphyria AT sanmartindevialelc effectofalipoicacidamideonhexachlorobenzeneporphyria AT delriosdemolinamc effectofalipoicacidamideonhexachlorobenzeneporphyria |
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1807324252525821952 |