Rhodotorula minuta-mediated bioreduction of 1,2-diketones

The reduction of cyclic and acyclic 1,2-diketones was investigated by employing whole cells of the yeast Rhodotorula minuta as biocatalyst. The reactions showed a variable degree of regio- and enantioselectivity depending on the nature of the substrate. In the case of cyclic diketones, the reduction...

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Autores principales:	Monsalve, L.N., Cerrutti, P., Galvagno, M.A., Baldessari, A.
Formato:	JOUR
Materias:	1,2-Diketones Bioreduction Rhodotorula minuta Bioreductions Diastereomeric Diastereomeric excess Diketones Enantiomeric excess High yield Reaction time Stereo-selective Two-step reactions Whole cell Enantioselectivity Ketones 1,2 cyclohexanediol derivative 1,2 diketone derivative 2 phenyl 2,3 propanedione 2,3 butanedione 2,3 pentanedione diketone unclassified drug article controlled study enantiomer enantioselectivity gas liquid chromatography nonhuman reduction Rhodotorula stereochemistry
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10242422_v28_n2_p137_Monsalve
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_10242422_v28_n2_p137_Monsalve
record_format	dspace
spelling	todo:paper_10242422_v28_n2_p137_Monsalve2023-10-03T15:56:52Z Rhodotorula minuta-mediated bioreduction of 1,2-diketones Monsalve, L.N. Cerrutti, P. Galvagno, M.A. Baldessari, A. 1,2-Diketones Bioreduction Rhodotorula minuta Bioreductions Diastereomeric Diastereomeric excess Diketones Enantiomeric excess High yield Reaction time Stereo-selective Two-step reactions Whole cell Enantioselectivity Ketones 1,2 cyclohexanediol derivative 1,2 diketone derivative 2 phenyl 2,3 propanedione 2,3 butanedione 2,3 pentanedione diketone unclassified drug article controlled study enantiomer enantioselectivity gas liquid chromatography nonhuman reduction Rhodotorula Rhodotorula minuta stereochemistry Rhodotorula minuta The reduction of cyclic and acyclic 1,2-diketones was investigated by employing whole cells of the yeast Rhodotorula minuta as biocatalyst. The reactions showed a variable degree of regio- and enantioselectivity depending on the nature of the substrate. In the case of cyclic diketones, the reduction afforded a mixture of diastereomeric diols only. The reduction of acyclic diketones allowed production of both the hydroxy ketone and the diol, in a two-step reaction. The first step was highly regio- and stereoselective, affording the hydroxy ketone of (S)-configuration with high enantiomeric excess. After longer reaction times the corresponding (S,S)-diols were obtained in high yield and diastereomeric excess. © 2010 Informa UK Ltd. Fil:Monsalve, L.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cerrutti, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Galvagno, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Baldessari, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10242422_v28_n2_p137_Monsalve
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	1,2-Diketones Bioreduction Rhodotorula minuta Bioreductions Diastereomeric Diastereomeric excess Diketones Enantiomeric excess High yield Reaction time Stereo-selective Two-step reactions Whole cell Enantioselectivity Ketones 1,2 cyclohexanediol derivative 1,2 diketone derivative 2 phenyl 2,3 propanedione 2,3 butanedione 2,3 pentanedione diketone unclassified drug article controlled study enantiomer enantioselectivity gas liquid chromatography nonhuman reduction Rhodotorula Rhodotorula minuta stereochemistry Rhodotorula minuta
spellingShingle	1,2-Diketones Bioreduction Rhodotorula minuta Bioreductions Diastereomeric Diastereomeric excess Diketones Enantiomeric excess High yield Reaction time Stereo-selective Two-step reactions Whole cell Enantioselectivity Ketones 1,2 cyclohexanediol derivative 1,2 diketone derivative 2 phenyl 2,3 propanedione 2,3 butanedione 2,3 pentanedione diketone unclassified drug article controlled study enantiomer enantioselectivity gas liquid chromatography nonhuman reduction Rhodotorula Rhodotorula minuta stereochemistry Rhodotorula minuta Monsalve, L.N. Cerrutti, P. Galvagno, M.A. Baldessari, A. Rhodotorula minuta-mediated bioreduction of 1,2-diketones
topic_facet	1,2-Diketones Bioreduction Rhodotorula minuta Bioreductions Diastereomeric Diastereomeric excess Diketones Enantiomeric excess High yield Reaction time Stereo-selective Two-step reactions Whole cell Enantioselectivity Ketones 1,2 cyclohexanediol derivative 1,2 diketone derivative 2 phenyl 2,3 propanedione 2,3 butanedione 2,3 pentanedione diketone unclassified drug article controlled study enantiomer enantioselectivity gas liquid chromatography nonhuman reduction Rhodotorula Rhodotorula minuta stereochemistry Rhodotorula minuta
description	The reduction of cyclic and acyclic 1,2-diketones was investigated by employing whole cells of the yeast Rhodotorula minuta as biocatalyst. The reactions showed a variable degree of regio- and enantioselectivity depending on the nature of the substrate. In the case of cyclic diketones, the reduction afforded a mixture of diastereomeric diols only. The reduction of acyclic diketones allowed production of both the hydroxy ketone and the diol, in a two-step reaction. The first step was highly regio- and stereoselective, affording the hydroxy ketone of (S)-configuration with high enantiomeric excess. After longer reaction times the corresponding (S,S)-diols were obtained in high yield and diastereomeric excess. © 2010 Informa UK Ltd.
format	JOUR
author	Monsalve, L.N. Cerrutti, P. Galvagno, M.A. Baldessari, A.
author_facet	Monsalve, L.N. Cerrutti, P. Galvagno, M.A. Baldessari, A.
author_sort	Monsalve, L.N.
title	Rhodotorula minuta-mediated bioreduction of 1,2-diketones
title_short	Rhodotorula minuta-mediated bioreduction of 1,2-diketones
title_full	Rhodotorula minuta-mediated bioreduction of 1,2-diketones
title_fullStr	Rhodotorula minuta-mediated bioreduction of 1,2-diketones
title_full_unstemmed	Rhodotorula minuta-mediated bioreduction of 1,2-diketones
title_sort	rhodotorula minuta-mediated bioreduction of 1,2-diketones
url	http://hdl.handle.net/20.500.12110/paper_10242422_v28_n2_p137_Monsalve
work_keys_str_mv	AT monsalveln rhodotorulaminutamediatedbioreductionof12diketones AT cerruttip rhodotorulaminutamediatedbioreductionof12diketones AT galvagnoma rhodotorulaminutamediatedbioreductionof12diketones AT baldessaria rhodotorulaminutamediatedbioreductionof12diketones
_version_	1782027144584495104

Rhodotorula minuta-mediated bioreduction of 1,2-diketones

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