Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis
Porphyrins are the only and most powerful photosensitizers synthesized internally. To understand better the involvement of porphyrins in photosensitization reactions, the heme biosynthetic pathway is first described, as well as the main features of its regulation in both erythroid and hepatic cells....
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todo:paper_10111344_v20_n1_p5_DelBatlle2023-10-03T15:56:13Z Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis Del Batlle, C.A.M. Cancer Carcinogenesis Photodynamic therapy Porphyrias Porphyrins aminolevulinic acid hematoporphyrin derivative photosensitizing agent phthalocyanine derivative porphyrin carcinogenesis heme synthesis human intratumoral drug administration photodynamic therapy porphyria review Aminolevulinic Acid Heme Human Models, Biological Neoplasms Photochemotherapy Porphyria Porphyrins Support, Non-U.S. Gov't Porphyrins are the only and most powerful photosensitizers synthesized internally. To understand better the involvement of porphyrins in photosensitization reactions, the heme biosynthetic pathway is first described, as well as the main features of its regulation in both erythroid and hepatic cells. Most disorders of porphyrin metabolism, known as porphyrias, are characterized by porphyrin accumulation. A full discussion of these diseases, their classification and relevant biochemical and clinical signs are presented. Abnormalities in heme biosynthesis in disorders other than porphyrias, such as iron-deficient and sideroblastic anemias, lead poisoning, hereditary tyrosinemia, chronic renal disease and alcoholism, are briefly considered. A complete survey of the experimental research on the biosynthesis of porphyrins in tumors and of the important association between cancer and porphyrias is dealt with. The link to photodynamic therapy (PDT) emerges naturally and this is treated from the point of view of using porphyrins endogenously formed by the tumors for their localization and PDT. Finally, considering the nature of the alterations occurring in heme metabolism in tumors, and porphyrias and their ubiquity, a model is discussed where the abnormality of heme synthesis is involved in the initiating lesion of carcinogenesis. The model strongly predicts that the incidence of cancer will be high in cells with abnormal heme metabolism, suggesting that porphyric patients may be at greater risk of the development of cancer. © 1993. Fil:Del Batlle, C.A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10111344_v20_n1_p5_DelBatlle |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cancer Carcinogenesis Photodynamic therapy Porphyrias Porphyrins aminolevulinic acid hematoporphyrin derivative photosensitizing agent phthalocyanine derivative porphyrin carcinogenesis heme synthesis human intratumoral drug administration photodynamic therapy porphyria review Aminolevulinic Acid Heme Human Models, Biological Neoplasms Photochemotherapy Porphyria Porphyrins Support, Non-U.S. Gov't |
| spellingShingle |
Cancer Carcinogenesis Photodynamic therapy Porphyrias Porphyrins aminolevulinic acid hematoporphyrin derivative photosensitizing agent phthalocyanine derivative porphyrin carcinogenesis heme synthesis human intratumoral drug administration photodynamic therapy porphyria review Aminolevulinic Acid Heme Human Models, Biological Neoplasms Photochemotherapy Porphyria Porphyrins Support, Non-U.S. Gov't Del Batlle, C.A.M. Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis |
| topic_facet |
Cancer Carcinogenesis Photodynamic therapy Porphyrias Porphyrins aminolevulinic acid hematoporphyrin derivative photosensitizing agent phthalocyanine derivative porphyrin carcinogenesis heme synthesis human intratumoral drug administration photodynamic therapy porphyria review Aminolevulinic Acid Heme Human Models, Biological Neoplasms Photochemotherapy Porphyria Porphyrins Support, Non-U.S. Gov't |
| description |
Porphyrins are the only and most powerful photosensitizers synthesized internally. To understand better the involvement of porphyrins in photosensitization reactions, the heme biosynthetic pathway is first described, as well as the main features of its regulation in both erythroid and hepatic cells. Most disorders of porphyrin metabolism, known as porphyrias, are characterized by porphyrin accumulation. A full discussion of these diseases, their classification and relevant biochemical and clinical signs are presented. Abnormalities in heme biosynthesis in disorders other than porphyrias, such as iron-deficient and sideroblastic anemias, lead poisoning, hereditary tyrosinemia, chronic renal disease and alcoholism, are briefly considered. A complete survey of the experimental research on the biosynthesis of porphyrins in tumors and of the important association between cancer and porphyrias is dealt with. The link to photodynamic therapy (PDT) emerges naturally and this is treated from the point of view of using porphyrins endogenously formed by the tumors for their localization and PDT. Finally, considering the nature of the alterations occurring in heme metabolism in tumors, and porphyrias and their ubiquity, a model is discussed where the abnormality of heme synthesis is involved in the initiating lesion of carcinogenesis. The model strongly predicts that the incidence of cancer will be high in cells with abnormal heme metabolism, suggesting that porphyric patients may be at greater risk of the development of cancer. © 1993. |
| format |
JOUR |
| author |
Del Batlle, C.A.M. |
| author_facet |
Del Batlle, C.A.M. |
| author_sort |
Del Batlle, C.A.M. |
| title |
Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis |
| title_short |
Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis |
| title_full |
Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis |
| title_fullStr |
Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis |
| title_full_unstemmed |
Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis |
| title_sort |
porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis |
| url |
http://hdl.handle.net/20.500.12110/paper_10111344_v20_n1_p5_DelBatlle |
| work_keys_str_mv |
AT delbatllecam porphyrinsporphyriascancerandphotodynamictherapyamodelforcarcinogenesis |
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1807319455432179712 |