Pathogenic lymphoid cells engineered to express TGF β1 ameliorate disease in a collagen-induced arthritic model

Collagen-induced arthritis in DBA/1 mice is a model of rheumatoid arthritis with marked synovitis and erosions. The disease can be adoptively transferred to SCID mice with arthritogenic splenocytes from DBA/1 mice injected with bovine collagen type II. However, infection of arthritogenic splenocytes...

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Detalles Bibliográficos
Autores principales: Chernajovsky, Y., Adams, G., Triantaphyllopoulos, K., Ledda, M.F., Podhajcer, O.L.
Formato: JOUR
Materias:
Cytokine receptors
Cytokines
Rheumatoid arthritis
T lymphocytes
TGF β1 retrovirus
collagen
collagen antibody
gelatinase
transforming growth factor beta1
animal cell
animal experiment
animal model
animal tissue
antiinflammatory activity
article
enzyme activity
gene transfer
lymphoid cell
male
mouse
nonhuman
paw edema
priority journal
protein expression
Retrovirus
rheumatoid arthritis
spleen cell
synovitis
T lymphocyte
Animalia
Bovinae
unidentified retrovirus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09697128_v4_n6_p553_Chernajovsky
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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