The carboxy terminal domain of RNA polymerase II and alternative splicing
Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of this polymerase is the presence of a highly repetitive carboxy terminal domain (C...
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todo:paper_09680004_v35_n9_p497_Munoz2023-10-03T15:55:09Z The carboxy terminal domain of RNA polymerase II and alternative splicing Muñoz, M.J. de la Mata, M. Kornblihtt, A.R. cyclin dependent kinase 7 RNA polymerase II small nuclear ribonucleoprotein alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly consensus sequence molecular dynamics nonhuman priority journal protein phosphorylation protein processing protein protein interaction review RNA capping RNA processing RNA translation spliceosome transcription regulation Alternative Splicing Animals Humans Phosphorylation Protein Processing, Post-Translational RNA Polymerase II Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of this polymerase is the presence of a highly repetitive carboxy terminal domain (CTD), which is subject to multiple regulatory post-translational modifications. CTD phosphorylation events affect the transcriptional properties of pol II and the outcome of co-transcriptional alternative splicing by mediating the effects of splicing factors and by modulating transcription elongation rates. Here, we discuss various examples of involvement of the CTD in alternative splicing regulation as well as the current methodological limitations in deciphering the detailed mechanisms of this process. © 2010 Elsevier Ltd. Fil:Muñoz, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:de la Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09680004_v35_n9_p497_Munoz |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
cyclin dependent kinase 7 RNA polymerase II small nuclear ribonucleoprotein alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly consensus sequence molecular dynamics nonhuman priority journal protein phosphorylation protein processing protein protein interaction review RNA capping RNA processing RNA translation spliceosome transcription regulation Alternative Splicing Animals Humans Phosphorylation Protein Processing, Post-Translational RNA Polymerase II |
spellingShingle |
cyclin dependent kinase 7 RNA polymerase II small nuclear ribonucleoprotein alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly consensus sequence molecular dynamics nonhuman priority journal protein phosphorylation protein processing protein protein interaction review RNA capping RNA processing RNA translation spliceosome transcription regulation Alternative Splicing Animals Humans Phosphorylation Protein Processing, Post-Translational RNA Polymerase II Muñoz, M.J. de la Mata, M. Kornblihtt, A.R. The carboxy terminal domain of RNA polymerase II and alternative splicing |
topic_facet |
cyclin dependent kinase 7 RNA polymerase II small nuclear ribonucleoprotein alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly consensus sequence molecular dynamics nonhuman priority journal protein phosphorylation protein processing protein protein interaction review RNA capping RNA processing RNA translation spliceosome transcription regulation Alternative Splicing Animals Humans Phosphorylation Protein Processing, Post-Translational RNA Polymerase II |
description |
Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of this polymerase is the presence of a highly repetitive carboxy terminal domain (CTD), which is subject to multiple regulatory post-translational modifications. CTD phosphorylation events affect the transcriptional properties of pol II and the outcome of co-transcriptional alternative splicing by mediating the effects of splicing factors and by modulating transcription elongation rates. Here, we discuss various examples of involvement of the CTD in alternative splicing regulation as well as the current methodological limitations in deciphering the detailed mechanisms of this process. © 2010 Elsevier Ltd. |
format |
JOUR |
author |
Muñoz, M.J. de la Mata, M. Kornblihtt, A.R. |
author_facet |
Muñoz, M.J. de la Mata, M. Kornblihtt, A.R. |
author_sort |
Muñoz, M.J. |
title |
The carboxy terminal domain of RNA polymerase II and alternative splicing |
title_short |
The carboxy terminal domain of RNA polymerase II and alternative splicing |
title_full |
The carboxy terminal domain of RNA polymerase II and alternative splicing |
title_fullStr |
The carboxy terminal domain of RNA polymerase II and alternative splicing |
title_full_unstemmed |
The carboxy terminal domain of RNA polymerase II and alternative splicing |
title_sort |
carboxy terminal domain of rna polymerase ii and alternative splicing |
url |
http://hdl.handle.net/20.500.12110/paper_09680004_v35_n9_p497_Munoz |
work_keys_str_mv |
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1782030805165408256 |