Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite

(±)-S-Ethyl-[3,7,11]-trimethyl-10,11-epoxy-2E,6E-dien-1-yl]-thiolcarb onate (1) and 4-phenoxyphenoxy ethyl tetrahydropyranyl ether (2) were shown to be very active antireplicative agents against intracellular Trypanosoma cruzi amastigotes in in vitro assays. Both of them had previously presented hig...

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Detalles Bibliográficos
Autores principales: Rodriguez, J.B., Zhong, L., Docampo, R., Gros, E.G.
Formato: JOUR
Materias:
antiparasitic agent
animal cell
article
cell proliferation
controlled study
in vitro study
myoblast
nonhuman
trypanosoma cruzi
Animalia
Trypanosoma
Trypanosoma cruzi
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0960894X_v6_n22_p2783_Rodriguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0960894X_v6_n22_p2783_Rodriguez
record_format dspace
spelling todo:paper_0960894X_v6_n22_p2783_Rodriguez2023-10-03T15:54:03Z Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite Rodriguez, J.B. Zhong, L. Docampo, R. Gros, E.G. antiparasitic agent animal cell article cell proliferation controlled study in vitro study myoblast nonhuman trypanosoma cruzi Animalia Trypanosoma Trypanosoma cruzi (±)-S-Ethyl-[3,7,11]-trimethyl-10,11-epoxy-2E,6E-dien-1-yl]-thiolcarb onate (1) and 4-phenoxyphenoxy ethyl tetrahydropyranyl ether (2) were shown to be very active antireplicative agents against intracellular Trypanosoma cruzi amastigotes in in vitro assays. Both of them had previously presented high biological activity as growth inhibitors of the epimastigote form of the parasite. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0960894X_v6_n22_p2783_Rodriguez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic antiparasitic agent
animal cell
article
cell proliferation
controlled study
in vitro study
myoblast
nonhuman
trypanosoma cruzi
Animalia
Trypanosoma
Trypanosoma cruzi
spellingShingle antiparasitic agent
animal cell
article
cell proliferation
controlled study
in vitro study
myoblast
nonhuman
trypanosoma cruzi
Animalia
Trypanosoma
Trypanosoma cruzi
Rodriguez, J.B.
Zhong, L.
Docampo, R.
Gros, E.G.
Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite
topic_facet antiparasitic agent
animal cell
article
cell proliferation
controlled study
in vitro study
myoblast
nonhuman
trypanosoma cruzi
Animalia
Trypanosoma
Trypanosoma cruzi
description (±)-S-Ethyl-[3,7,11]-trimethyl-10,11-epoxy-2E,6E-dien-1-yl]-thiolcarb onate (1) and 4-phenoxyphenoxy ethyl tetrahydropyranyl ether (2) were shown to be very active antireplicative agents against intracellular Trypanosoma cruzi amastigotes in in vitro assays. Both of them had previously presented high biological activity as growth inhibitors of the epimastigote form of the parasite.
format JOUR
author Rodriguez, J.B.
Zhong, L.
Docampo, R.
Gros, E.G.
author_facet Rodriguez, J.B.
Zhong, L.
Docampo, R.
Gros, E.G.
author_sort Rodriguez, J.B.
title Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite
title_short Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite
title_full Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite
title_fullStr Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite
title_full_unstemmed Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite
title_sort biological evaluation of two potent inhibitors of trypanosoma cruzi epimastigotes against the intracellular form of the parasite
url http://hdl.handle.net/20.500.12110/paper_0960894X_v6_n22_p2783_Rodriguez
work_keys_str_mv AT rodriguezjb biologicalevaluationoftwopotentinhibitorsoftrypanosomacruziepimastigotesagainsttheintracellularformoftheparasite
AT zhongl biologicalevaluationoftwopotentinhibitorsoftrypanosomacruziepimastigotesagainsttheintracellularformoftheparasite
AT docampor biologicalevaluationoftwopotentinhibitorsoftrypanosomacruziepimastigotesagainsttheintracellularformoftheparasite
AT groseg biologicalevaluationoftwopotentinhibitorsoftrypanosomacruziepimastigotesagainsttheintracellularformoftheparasite
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