Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts
Unlike the preparation of other purine nucleosides, transglycosylation from a pyrimidine nucleoside and guanine is difficult because of the low solubility of this base. Thus, another strategy, based on the coupled action of two whole cell biocatalyzed reactions, transglycosylation and deamination, w...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0960894X_v19_n15_p4210_Medici |
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todo:paper_0960894X_v19_n15_p4210_Medici2023-10-03T15:54:00Z Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts Médici, R. Iribarren, A.M. Lewkowicz, E.S. Adenosine deaminase Arabinofuranosylguanine Nucleoside phosphorylases Whole cell biocatalysts guanine guanine arabinoside purine nucleoside pyrimidine nucleoside Arthrobacter article biocatalyst catalysis deamination drug structure drug synthesis Enterobacter glycosylation high performance liquid chromatography nonhuman Antineoplastic Agents Arabinonucleosides Arthrobacter Catalysis Cell Line Cell Line, Tumor Chemistry, Pharmaceutical Drug Design Drug Screening Assays, Antitumor Enterobacter Glycosylation Humans Leukemia Models, Chemical Arthrobacter oxydans Enterobacter gergoviae Unlike the preparation of other purine nucleosides, transglycosylation from a pyrimidine nucleoside and guanine is difficult because of the low solubility of this base. Thus, another strategy, based on the coupled action of two whole cell biocatalyzed reactions, transglycosylation and deamination, was used. Enterobacter gergoviae and Arthrobacter oxydans were employed to synthesize 9-β-d-arabinofuranosylguanine (AraG), an efficient anti leukemic drug. © 2009 Elsevier Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0960894X_v19_n15_p4210_Medici |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Adenosine deaminase Arabinofuranosylguanine Nucleoside phosphorylases Whole cell biocatalysts guanine guanine arabinoside purine nucleoside pyrimidine nucleoside Arthrobacter article biocatalyst catalysis deamination drug structure drug synthesis Enterobacter glycosylation high performance liquid chromatography nonhuman Antineoplastic Agents Arabinonucleosides Arthrobacter Catalysis Cell Line Cell Line, Tumor Chemistry, Pharmaceutical Drug Design Drug Screening Assays, Antitumor Enterobacter Glycosylation Humans Leukemia Models, Chemical Arthrobacter oxydans Enterobacter gergoviae |
| spellingShingle |
Adenosine deaminase Arabinofuranosylguanine Nucleoside phosphorylases Whole cell biocatalysts guanine guanine arabinoside purine nucleoside pyrimidine nucleoside Arthrobacter article biocatalyst catalysis deamination drug structure drug synthesis Enterobacter glycosylation high performance liquid chromatography nonhuman Antineoplastic Agents Arabinonucleosides Arthrobacter Catalysis Cell Line Cell Line, Tumor Chemistry, Pharmaceutical Drug Design Drug Screening Assays, Antitumor Enterobacter Glycosylation Humans Leukemia Models, Chemical Arthrobacter oxydans Enterobacter gergoviae Médici, R. Iribarren, A.M. Lewkowicz, E.S. Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts |
| topic_facet |
Adenosine deaminase Arabinofuranosylguanine Nucleoside phosphorylases Whole cell biocatalysts guanine guanine arabinoside purine nucleoside pyrimidine nucleoside Arthrobacter article biocatalyst catalysis deamination drug structure drug synthesis Enterobacter glycosylation high performance liquid chromatography nonhuman Antineoplastic Agents Arabinonucleosides Arthrobacter Catalysis Cell Line Cell Line, Tumor Chemistry, Pharmaceutical Drug Design Drug Screening Assays, Antitumor Enterobacter Glycosylation Humans Leukemia Models, Chemical Arthrobacter oxydans Enterobacter gergoviae |
| description |
Unlike the preparation of other purine nucleosides, transglycosylation from a pyrimidine nucleoside and guanine is difficult because of the low solubility of this base. Thus, another strategy, based on the coupled action of two whole cell biocatalyzed reactions, transglycosylation and deamination, was used. Enterobacter gergoviae and Arthrobacter oxydans were employed to synthesize 9-β-d-arabinofuranosylguanine (AraG), an efficient anti leukemic drug. © 2009 Elsevier Ltd. All rights reserved. |
| format |
JOUR |
| author |
Médici, R. Iribarren, A.M. Lewkowicz, E.S. |
| author_facet |
Médici, R. Iribarren, A.M. Lewkowicz, E.S. |
| author_sort |
Médici, R. |
| title |
Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts |
| title_short |
Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts |
| title_full |
Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts |
| title_fullStr |
Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts |
| title_full_unstemmed |
Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts |
| title_sort |
synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts |
| url |
http://hdl.handle.net/20.500.12110/paper_0960894X_v19_n15_p4210_Medici |
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AT medicir synthesisof9bdarabinofuranosylguaninebycombineduseoftwowholecellbiocatalysts AT iribarrenam synthesisof9bdarabinofuranosylguaninebycombineduseoftwowholecellbiocatalysts AT lewkowiczes synthesisof9bdarabinofuranosylguaninebycombineduseoftwowholecellbiocatalysts |
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1782028292583325696 |