Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase
Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular for...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n19_p3231_Szajnman |
| Aporte de: |
| id |
todo:paper_0960894X_v13_n19_p3231_Szajnman |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_0960894X_v13_n19_p3231_Szajnman2023-10-03T15:53:58Z Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase Szajnman, S.H. Montalvetti, A. Wang, Y. Docampo, R. Rodriguez, J.B. fatty acid derivative geranyltransferase phosphonic acid derivative anorexia article cell proliferation drug approval drug potency food and drug administration IC 50 in vitro study inhibition kinetics nonhuman osteolysis parasite peripheral neuropathy skin allergy tropical disease Trypanosoma cruzi vomiting Trypanosoma Trypanosoma cruzi Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases. © 2003 Elsevier Ltd. All rights reserved. Fil:Szajnman, S.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n19_p3231_Szajnman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
fatty acid derivative geranyltransferase phosphonic acid derivative anorexia article cell proliferation drug approval drug potency food and drug administration IC 50 in vitro study inhibition kinetics nonhuman osteolysis parasite peripheral neuropathy skin allergy tropical disease Trypanosoma cruzi vomiting Trypanosoma Trypanosoma cruzi |
| spellingShingle |
fatty acid derivative geranyltransferase phosphonic acid derivative anorexia article cell proliferation drug approval drug potency food and drug administration IC 50 in vitro study inhibition kinetics nonhuman osteolysis parasite peripheral neuropathy skin allergy tropical disease Trypanosoma cruzi vomiting Trypanosoma Trypanosoma cruzi Szajnman, S.H. Montalvetti, A. Wang, Y. Docampo, R. Rodriguez, J.B. Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| topic_facet |
fatty acid derivative geranyltransferase phosphonic acid derivative anorexia article cell proliferation drug approval drug potency food and drug administration IC 50 in vitro study inhibition kinetics nonhuman osteolysis parasite peripheral neuropathy skin allergy tropical disease Trypanosoma cruzi vomiting Trypanosoma Trypanosoma cruzi |
| description |
Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases. © 2003 Elsevier Ltd. All rights reserved. |
| format |
JOUR |
| author |
Szajnman, S.H. Montalvetti, A. Wang, Y. Docampo, R. Rodriguez, J.B. |
| author_facet |
Szajnman, S.H. Montalvetti, A. Wang, Y. Docampo, R. Rodriguez, J.B. |
| author_sort |
Szajnman, S.H. |
| title |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_short |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_full |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_fullStr |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_full_unstemmed |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase |
| title_sort |
bisphosphonates derived from fatty acids are potent inhibitors of trypanosoma cruzi farnesyl pyrophosphate synthase |
| url |
http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n19_p3231_Szajnman |
| work_keys_str_mv |
AT szajnmansh bisphosphonatesderivedfromfattyacidsarepotentinhibitorsoftrypanosomacruzifarnesylpyrophosphatesynthase AT montalvettia bisphosphonatesderivedfromfattyacidsarepotentinhibitorsoftrypanosomacruzifarnesylpyrophosphatesynthase AT wangy bisphosphonatesderivedfromfattyacidsarepotentinhibitorsoftrypanosomacruzifarnesylpyrophosphatesynthase AT docampor bisphosphonatesderivedfromfattyacidsarepotentinhibitorsoftrypanosomacruzifarnesylpyrophosphatesynthase AT rodriguezjb bisphosphonatesderivedfromfattyacidsarepotentinhibitorsoftrypanosomacruzifarnesylpyrophosphatesynthase |
| _version_ |
1782028821210333184 |