Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings
The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2% w/w scleroglucan gel matrix loaded and 0, 0.02, 0.04,...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09598103_v54_n12_p1613_Francois |
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todo:paper_09598103_v54_n12_p1613_Francois2023-10-03T15:53:13Z Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings François, N.J. Rojas, A.M. Daraio, M.E. Biopolymer Drug loading Drug release Dynamic rheology Scleroglucan Theophylline Biopolymers Controlled drug delivery Materials testing Molecular structure Molecular weight Pharmacokinetics Rheology Drug loadings Drug-release behaviour Dynamic rheology Gel structural properties Scleroglucan gel matrix Theophylline Gels drug delivery The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2% w/w scleroglucan gel matrix loaded and 0, 0.02, 0.04, 0.06, 0.2 0.4% w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled-stress rotational-shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi-empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04-0.06% w/ w Th range a plasticizing effect and in the 0.2-0.4% w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug-release kinetics. © 2005 Society of Chemical Industry. Fil:Rojas, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Daraio, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09598103_v54_n12_p1613_Francois |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Biopolymer Drug loading Drug release Dynamic rheology Scleroglucan Theophylline Biopolymers Controlled drug delivery Materials testing Molecular structure Molecular weight Pharmacokinetics Rheology Drug loadings Drug-release behaviour Dynamic rheology Gel structural properties Scleroglucan gel matrix Theophylline Gels drug delivery |
| spellingShingle |
Biopolymer Drug loading Drug release Dynamic rheology Scleroglucan Theophylline Biopolymers Controlled drug delivery Materials testing Molecular structure Molecular weight Pharmacokinetics Rheology Drug loadings Drug-release behaviour Dynamic rheology Gel structural properties Scleroglucan gel matrix Theophylline Gels drug delivery François, N.J. Rojas, A.M. Daraio, M.E. Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings |
| topic_facet |
Biopolymer Drug loading Drug release Dynamic rheology Scleroglucan Theophylline Biopolymers Controlled drug delivery Materials testing Molecular structure Molecular weight Pharmacokinetics Rheology Drug loadings Drug-release behaviour Dynamic rheology Gel structural properties Scleroglucan gel matrix Theophylline Gels drug delivery |
| description |
The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2% w/w scleroglucan gel matrix loaded and 0, 0.02, 0.04, 0.06, 0.2 0.4% w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled-stress rotational-shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi-empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04-0.06% w/ w Th range a plasticizing effect and in the 0.2-0.4% w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug-release kinetics. © 2005 Society of Chemical Industry. |
| format |
JOUR |
| author |
François, N.J. Rojas, A.M. Daraio, M.E. |
| author_facet |
François, N.J. Rojas, A.M. Daraio, M.E. |
| author_sort |
François, N.J. |
| title |
Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings |
| title_short |
Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings |
| title_full |
Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings |
| title_fullStr |
Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings |
| title_full_unstemmed |
Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings |
| title_sort |
rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings |
| url |
http://hdl.handle.net/20.500.12110/paper_09598103_v54_n12_p1613_Francois |
| work_keys_str_mv |
AT francoisnj rheologicalanddrugreleasebehaviourofascleroglucangelmatrixatdifferentdrugloadings AT rojasam rheologicalanddrugreleasebehaviourofascleroglucangelmatrixatdifferentdrugloadings AT daraiome rheologicalanddrugreleasebehaviourofascleroglucangelmatrixatdifferentdrugloadings |
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1807323303348535296 |