Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment
Abnormal glycosylation is a typical hallmark of the transition from healthy to neoplastic tissues. Although the importance of glycans and glycan-binding proteins in cancer-related processes such as tumor cell adhesion, migration, metastasis and immune escape has been largely appreciated, our awarene...
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todo:paper_09596658_v24_n12_p1283_Croci2023-10-03T15:53:07Z Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment Croci, D.O. Cerliani, J.P. Pinto, N.A. GMorosi, L. Rabinovich, G.A. Angiogenesis Galectin-1 Galectins Glycosylation Hypoxia Immunotherapy Lectins Vasculature activated leukocyte cell adhesion molecule angiopoietin 2 fibroblast growth factor 2 galectin galectin 1 galectin 2 galectin 4 galectin 8 glycan glycosyltransferase granulocyte colony stimulating factor interleukin 17 interleukin 6 interleukin 8 lectin receptor mannosidase neuropilin 1 placental growth factor platelet derived growth factor beta receptor scatter factor sulfotransferase vasculotropin receptor 2 angiogenesis inhibitor polysaccharide amino terminal sequence angiogenesis antiangiogenic therapy blood vessel permeability breast cancer cell differentiation cell maturation cell migration cell proliferation cell survival dendritic cell down regulation endothelium cell gene expression glioblastoma glycosylation human hypoxia Kaposi sarcoma lung adenocarcinoma melanoma microglia nonhuman pancreas adenocarcinoma preeclampsia priority journal prostate adenocarcinoma Review signal transduction T cell lymphoma Th1 cell Th17 cell tumor biopsy tumor microenvironment tumor vascularization upregulation vascular biology anoxia metabolism Neoplasms Neovascularization, Pathologic Angiogenesis Inhibitors Anoxia Endothelial Cells Glycosylation Humans Neoplasms Neovascularization, Pathologic Polysaccharides Signal Transduction Abnormal glycosylation is a typical hallmark of the transition from healthy to neoplastic tissues. Although the importance of glycans and glycan-binding proteins in cancer-related processes such as tumor cell adhesion, migration, metastasis and immune escape has been largely appreciated, our awareness of the impact of lectin-glycan recognition in tumor vascularization is relatively new. Regulated glycosylation can influence vascular biology by controlling trafficking, endocytosis and signaling of endothelial cell (EC) receptors including vascular endothelial growth factor receptors, platelet EC adhesion molecule, Notch and integrins. In addition, glycans may control angiogenesis by regulating migration of endothelial tip cells and influencing EC survival and vascular permeability. Recent evidence indicated that changes in the EC surface glycome may also serve “on-and-offâ€switches that control galectin binding to signaling receptors by displaying or masking-specific glycan epitopes. These glycosylation-dependent lectin-receptor interactions can link tumor hypoxia to EC signaling and control tumor sensitivity to anti-angiogenic treatment. © The Author 2014. Published by Oxford University Press. All rights reserved. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09596658_v24_n12_p1283_Croci |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiogenesis Galectin-1 Galectins Glycosylation Hypoxia Immunotherapy Lectins Vasculature activated leukocyte cell adhesion molecule angiopoietin 2 fibroblast growth factor 2 galectin galectin 1 galectin 2 galectin 4 galectin 8 glycan glycosyltransferase granulocyte colony stimulating factor interleukin 17 interleukin 6 interleukin 8 lectin receptor mannosidase neuropilin 1 placental growth factor platelet derived growth factor beta receptor scatter factor sulfotransferase vasculotropin receptor 2 angiogenesis inhibitor polysaccharide amino terminal sequence angiogenesis antiangiogenic therapy blood vessel permeability breast cancer cell differentiation cell maturation cell migration cell proliferation cell survival dendritic cell down regulation endothelium cell gene expression glioblastoma glycosylation human hypoxia Kaposi sarcoma lung adenocarcinoma melanoma microglia nonhuman pancreas adenocarcinoma preeclampsia priority journal prostate adenocarcinoma Review signal transduction T cell lymphoma Th1 cell Th17 cell tumor biopsy tumor microenvironment tumor vascularization upregulation vascular biology anoxia metabolism Neoplasms Neovascularization, Pathologic Angiogenesis Inhibitors Anoxia Endothelial Cells Glycosylation Humans Neoplasms Neovascularization, Pathologic Polysaccharides Signal Transduction |
| spellingShingle |
Angiogenesis Galectin-1 Galectins Glycosylation Hypoxia Immunotherapy Lectins Vasculature activated leukocyte cell adhesion molecule angiopoietin 2 fibroblast growth factor 2 galectin galectin 1 galectin 2 galectin 4 galectin 8 glycan glycosyltransferase granulocyte colony stimulating factor interleukin 17 interleukin 6 interleukin 8 lectin receptor mannosidase neuropilin 1 placental growth factor platelet derived growth factor beta receptor scatter factor sulfotransferase vasculotropin receptor 2 angiogenesis inhibitor polysaccharide amino terminal sequence angiogenesis antiangiogenic therapy blood vessel permeability breast cancer cell differentiation cell maturation cell migration cell proliferation cell survival dendritic cell down regulation endothelium cell gene expression glioblastoma glycosylation human hypoxia Kaposi sarcoma lung adenocarcinoma melanoma microglia nonhuman pancreas adenocarcinoma preeclampsia priority journal prostate adenocarcinoma Review signal transduction T cell lymphoma Th1 cell Th17 cell tumor biopsy tumor microenvironment tumor vascularization upregulation vascular biology anoxia metabolism Neoplasms Neovascularization, Pathologic Angiogenesis Inhibitors Anoxia Endothelial Cells Glycosylation Humans Neoplasms Neovascularization, Pathologic Polysaccharides Signal Transduction Croci, D.O. Cerliani, J.P. Pinto, N.A. GMorosi, L. Rabinovich, G.A. Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment |
| topic_facet |
Angiogenesis Galectin-1 Galectins Glycosylation Hypoxia Immunotherapy Lectins Vasculature activated leukocyte cell adhesion molecule angiopoietin 2 fibroblast growth factor 2 galectin galectin 1 galectin 2 galectin 4 galectin 8 glycan glycosyltransferase granulocyte colony stimulating factor interleukin 17 interleukin 6 interleukin 8 lectin receptor mannosidase neuropilin 1 placental growth factor platelet derived growth factor beta receptor scatter factor sulfotransferase vasculotropin receptor 2 angiogenesis inhibitor polysaccharide amino terminal sequence angiogenesis antiangiogenic therapy blood vessel permeability breast cancer cell differentiation cell maturation cell migration cell proliferation cell survival dendritic cell down regulation endothelium cell gene expression glioblastoma glycosylation human hypoxia Kaposi sarcoma lung adenocarcinoma melanoma microglia nonhuman pancreas adenocarcinoma preeclampsia priority journal prostate adenocarcinoma Review signal transduction T cell lymphoma Th1 cell Th17 cell tumor biopsy tumor microenvironment tumor vascularization upregulation vascular biology anoxia metabolism Neoplasms Neovascularization, Pathologic Angiogenesis Inhibitors Anoxia Endothelial Cells Glycosylation Humans Neoplasms Neovascularization, Pathologic Polysaccharides Signal Transduction |
| description |
Abnormal glycosylation is a typical hallmark of the transition from healthy to neoplastic tissues. Although the importance of glycans and glycan-binding proteins in cancer-related processes such as tumor cell adhesion, migration, metastasis and immune escape has been largely appreciated, our awareness of the impact of lectin-glycan recognition in tumor vascularization is relatively new. Regulated glycosylation can influence vascular biology by controlling trafficking, endocytosis and signaling of endothelial cell (EC) receptors including vascular endothelial growth factor receptors, platelet EC adhesion molecule, Notch and integrins. In addition, glycans may control angiogenesis by regulating migration of endothelial tip cells and influencing EC survival and vascular permeability. Recent evidence indicated that changes in the EC surface glycome may also serve “on-and-offâ€switches that control galectin binding to signaling receptors by displaying or masking-specific glycan epitopes. These glycosylation-dependent lectin-receptor interactions can link tumor hypoxia to EC signaling and control tumor sensitivity to anti-angiogenic treatment. © The Author 2014. Published by Oxford University Press. All rights reserved. |
| format |
JOUR |
| author |
Croci, D.O. Cerliani, J.P. Pinto, N.A. GMorosi, L. Rabinovich, G.A. |
| author_facet |
Croci, D.O. Cerliani, J.P. Pinto, N.A. GMorosi, L. Rabinovich, G.A. |
| author_sort |
Croci, D.O. |
| title |
Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment |
| title_short |
Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment |
| title_full |
Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment |
| title_fullStr |
Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment |
| title_full_unstemmed |
Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment |
| title_sort |
regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment |
| url |
http://hdl.handle.net/20.500.12110/paper_09596658_v24_n12_p1283_Croci |
| work_keys_str_mv |
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| _version_ |
1782030940992700416 |