Glycans and galectins in prostate cancer biology, angiogenesis and metastasis
Prostate cancer is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide. While localized prostate cancer can be cured, advanced and metastatic prostate cancer remains a significant therapeutic challenge. Malignant transformation is associated with im...
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todo:paper_09596658_v24_n10_p899_Compagno2023-10-03T15:53:06Z Glycans and galectins in prostate cancer biology, angiogenesis and metastasis Compagno, D. Gentilini, L.D. Jaworski, F.M. Pérez, I.G. Contrufo, G. Laderach, D.J. Angiogenesis and metastasis Carbohydrate Galectin Glycan Prostate tumor galectin galectin 1 galectin 3 galectin 8 glycan glycoconjugate lectin galectin polysaccharide angiogenesis apoptosis cell invasion cell migration cell proliferation glycosylation human metastasis nonhuman primary tumor priority journal prostate cancer protein expression Review tumor cell cell motion gene expression regulation genetics male metabolism metastasis neovascularization (pathology) pathology prostate tumor Apoptosis Cell Movement Cell Proliferation Galectins Gene Expression Regulation, Neoplastic Humans Male Neoplasm Metastasis Neovascularization, Pathologic Polysaccharides Prostatic Neoplasms Prostate cancer is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide. While localized prostate cancer can be cured, advanced and metastatic prostate cancer remains a significant therapeutic challenge. Malignant transformation is associated with important modifications of the cellular glycosylation profile, and it is postulated that these changes have a considerable relevance for tumor biology. Metastasis is a multiphasic process that encompasses angiogenesis, the spread of tumor cells and their growth at distant sites from the primary tumor location. Recognition of glycoconjugates by galectins, among other lectins, plays a fundamental role in the metastatic spread, tumor immune escape and the neovascularization process. Particularly in prostate cancer, both carbohydrates and galectins have been implicated in many cellular processes such as proliferation, apoptosis, migration and invasion. However, a limited number of studies assessed their potential implications in the induction of metastasis in prostate cancer patients or in animal models. Moreover, the role of galectin-glycan interactions in vivo still remains poorly understood; concerted effort should thus be made in order to shed some light on this question. This review summarizes current evidence on both the expression and role of glycans and galectins in prostate cancer, particularly turning our attention to the angiogenic and metastatic processes. © The Author 2014. Published by Oxford University Press. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09596658_v24_n10_p899_Compagno |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiogenesis and metastasis Carbohydrate Galectin Glycan Prostate tumor galectin galectin 1 galectin 3 galectin 8 glycan glycoconjugate lectin galectin polysaccharide angiogenesis apoptosis cell invasion cell migration cell proliferation glycosylation human metastasis nonhuman primary tumor priority journal prostate cancer protein expression Review tumor cell cell motion gene expression regulation genetics male metabolism metastasis neovascularization (pathology) pathology prostate tumor Apoptosis Cell Movement Cell Proliferation Galectins Gene Expression Regulation, Neoplastic Humans Male Neoplasm Metastasis Neovascularization, Pathologic Polysaccharides Prostatic Neoplasms |
| spellingShingle |
Angiogenesis and metastasis Carbohydrate Galectin Glycan Prostate tumor galectin galectin 1 galectin 3 galectin 8 glycan glycoconjugate lectin galectin polysaccharide angiogenesis apoptosis cell invasion cell migration cell proliferation glycosylation human metastasis nonhuman primary tumor priority journal prostate cancer protein expression Review tumor cell cell motion gene expression regulation genetics male metabolism metastasis neovascularization (pathology) pathology prostate tumor Apoptosis Cell Movement Cell Proliferation Galectins Gene Expression Regulation, Neoplastic Humans Male Neoplasm Metastasis Neovascularization, Pathologic Polysaccharides Prostatic Neoplasms Compagno, D. Gentilini, L.D. Jaworski, F.M. Pérez, I.G. Contrufo, G. Laderach, D.J. Glycans and galectins in prostate cancer biology, angiogenesis and metastasis |
| topic_facet |
Angiogenesis and metastasis Carbohydrate Galectin Glycan Prostate tumor galectin galectin 1 galectin 3 galectin 8 glycan glycoconjugate lectin galectin polysaccharide angiogenesis apoptosis cell invasion cell migration cell proliferation glycosylation human metastasis nonhuman primary tumor priority journal prostate cancer protein expression Review tumor cell cell motion gene expression regulation genetics male metabolism metastasis neovascularization (pathology) pathology prostate tumor Apoptosis Cell Movement Cell Proliferation Galectins Gene Expression Regulation, Neoplastic Humans Male Neoplasm Metastasis Neovascularization, Pathologic Polysaccharides Prostatic Neoplasms |
| description |
Prostate cancer is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide. While localized prostate cancer can be cured, advanced and metastatic prostate cancer remains a significant therapeutic challenge. Malignant transformation is associated with important modifications of the cellular glycosylation profile, and it is postulated that these changes have a considerable relevance for tumor biology. Metastasis is a multiphasic process that encompasses angiogenesis, the spread of tumor cells and their growth at distant sites from the primary tumor location. Recognition of glycoconjugates by galectins, among other lectins, plays a fundamental role in the metastatic spread, tumor immune escape and the neovascularization process. Particularly in prostate cancer, both carbohydrates and galectins have been implicated in many cellular processes such as proliferation, apoptosis, migration and invasion. However, a limited number of studies assessed their potential implications in the induction of metastasis in prostate cancer patients or in animal models. Moreover, the role of galectin-glycan interactions in vivo still remains poorly understood; concerted effort should thus be made in order to shed some light on this question. This review summarizes current evidence on both the expression and role of glycans and galectins in prostate cancer, particularly turning our attention to the angiogenic and metastatic processes. © The Author 2014. Published by Oxford University Press. All rights reserved. |
| format |
JOUR |
| author |
Compagno, D. Gentilini, L.D. Jaworski, F.M. Pérez, I.G. Contrufo, G. Laderach, D.J. |
| author_facet |
Compagno, D. Gentilini, L.D. Jaworski, F.M. Pérez, I.G. Contrufo, G. Laderach, D.J. |
| author_sort |
Compagno, D. |
| title |
Glycans and galectins in prostate cancer biology, angiogenesis and metastasis |
| title_short |
Glycans and galectins in prostate cancer biology, angiogenesis and metastasis |
| title_full |
Glycans and galectins in prostate cancer biology, angiogenesis and metastasis |
| title_fullStr |
Glycans and galectins in prostate cancer biology, angiogenesis and metastasis |
| title_full_unstemmed |
Glycans and galectins in prostate cancer biology, angiogenesis and metastasis |
| title_sort |
glycans and galectins in prostate cancer biology, angiogenesis and metastasis |
| url |
http://hdl.handle.net/20.500.12110/paper_09596658_v24_n10_p899_Compagno |
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