Dexamethasone up-regulates mRNA for Na+,K+-ATPase in some spinal cord neurones after cord transection

We have studied the effects of spinal cord transection and of dexamethasone (DEX) treatment on mRNA biosynthesis of the Na+,K+-ATPase, a key enzyme necessary for neurotransmission, membrane repolarization and nutrient uptake in the CNS. In situ hybridization analysis revealed a significant reduction...

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Detalles Bibliográficos
Autores principales:	Gonzalez, S., Grillo, C., Gonzalez Deniselle, M.C., Lima, A., McEwen, B.S., De Nicola, A.F.
Formato:	JOUR
Materias:	CNS injury Dexamethasone Glucocorticoid In situ hybridization Na+,K+-ATPase Spinal cord adenosine triphosphatase (potassium sodium) dexamethasone messenger RNA animal model animal tissue article controlled study enzyme active site in situ hybridization male messenger RNA synthesis nonhuman priority journal rat spinal cord injury spinal cord nerve cell spinal cord transsection spinal cord ventral horn subcutaneous drug administration
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09594965_v7_n5_p1041_Gonzalez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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