Neuroleptics differentially modulate central dopamine d1-receptor binding
The effect of the classical neuroleptic, fluphenazine, on dopamine D1-receptor binding was examined in different regions of the basal ganglia. Whereas exposure to fluphenazine for 18 months reduced [125I]SCH-23982 binding to D1-receptors in the caudate putamen, nucleus accumbens and olfactory tuberc...
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todo:paper_09594965_v6_n6_p933_Johnson2023-10-03T15:53:00Z Neuroleptics differentially modulate central dopamine d1-receptor binding Johnson, A.E. Coirini, H. Källström, L. Gunne, L.M. Wiesel, F.A. Basal ganglia D1-receptors Dopamine Entopeduncular nucleus Entopeduncular nucleus Extrapyramidal motor system Fluphenazine Neuroleptic Striatum [125I]SCH-23982 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 7,8 dihydroxy 1 phenyl 1h 3 benzazepine 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor fluphenazine neuroleptic agent raclopride animal experiment animal tissue article brain region controlled study corpus striatum entopeduncular nucleus female intramuscular drug administration nonhuman priority journal rat receptor binding substantia nigra Animal Antipsychotic Agents Autoradiography Basal Ganglia Binding, Competitive Dopamine Antagonists Female Iodine Radioisotopes Rats Rats, Sprague-Dawley Receptors, Dopamine D1 Sch-23390 The effect of the classical neuroleptic, fluphenazine, on dopamine D1-receptor binding was examined in different regions of the basal ganglia. Whereas exposure to fluphenazine for 18 months reduced [125I]SCH-23982 binding to D1-receptors in the caudate putamen, nucleus accumbens and olfactory tubercle, binding in the entopeduncular nucleus was enhanced after fluphenazine treatment. Competition studies indicated that the region-dependent changes in [125I]SCH-23982 binding after fluphenazine exposure were not due to differences in the affinity of fluphenazine or other dopamine ligands for D1-binding sites. These data suggest that in addition to modulating striatal function, classical neuroleptics may also alter neurotransmission in the basal ganglia by enhancing dopamine receptor binding in the entopeduncular nucleus. © Rapid Communications of Oxford Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09594965_v6_n6_p933_Johnson |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
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Basal ganglia D1-receptors Dopamine Entopeduncular nucleus Entopeduncular nucleus Extrapyramidal motor system Fluphenazine Neuroleptic Striatum [125I]SCH-23982 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 7,8 dihydroxy 1 phenyl 1h 3 benzazepine 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor fluphenazine neuroleptic agent raclopride animal experiment animal tissue article brain region controlled study corpus striatum entopeduncular nucleus female intramuscular drug administration nonhuman priority journal rat receptor binding substantia nigra Animal Antipsychotic Agents Autoradiography Basal Ganglia Binding, Competitive Dopamine Antagonists Female Iodine Radioisotopes Rats Rats, Sprague-Dawley Receptors, Dopamine D1 Sch-23390 |
| spellingShingle |
Basal ganglia D1-receptors Dopamine Entopeduncular nucleus Entopeduncular nucleus Extrapyramidal motor system Fluphenazine Neuroleptic Striatum [125I]SCH-23982 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 7,8 dihydroxy 1 phenyl 1h 3 benzazepine 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor fluphenazine neuroleptic agent raclopride animal experiment animal tissue article brain region controlled study corpus striatum entopeduncular nucleus female intramuscular drug administration nonhuman priority journal rat receptor binding substantia nigra Animal Antipsychotic Agents Autoradiography Basal Ganglia Binding, Competitive Dopamine Antagonists Female Iodine Radioisotopes Rats Rats, Sprague-Dawley Receptors, Dopamine D1 Sch-23390 Johnson, A.E. Coirini, H. Källström, L. Gunne, L.M. Wiesel, F.A. Neuroleptics differentially modulate central dopamine d1-receptor binding |
| topic_facet |
Basal ganglia D1-receptors Dopamine Entopeduncular nucleus Entopeduncular nucleus Extrapyramidal motor system Fluphenazine Neuroleptic Striatum [125I]SCH-23982 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 7,8 dihydroxy 1 phenyl 1h 3 benzazepine 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor fluphenazine neuroleptic agent raclopride animal experiment animal tissue article brain region controlled study corpus striatum entopeduncular nucleus female intramuscular drug administration nonhuman priority journal rat receptor binding substantia nigra Animal Antipsychotic Agents Autoradiography Basal Ganglia Binding, Competitive Dopamine Antagonists Female Iodine Radioisotopes Rats Rats, Sprague-Dawley Receptors, Dopamine D1 Sch-23390 |
| description |
The effect of the classical neuroleptic, fluphenazine, on dopamine D1-receptor binding was examined in different regions of the basal ganglia. Whereas exposure to fluphenazine for 18 months reduced [125I]SCH-23982 binding to D1-receptors in the caudate putamen, nucleus accumbens and olfactory tubercle, binding in the entopeduncular nucleus was enhanced after fluphenazine treatment. Competition studies indicated that the region-dependent changes in [125I]SCH-23982 binding after fluphenazine exposure were not due to differences in the affinity of fluphenazine or other dopamine ligands for D1-binding sites. These data suggest that in addition to modulating striatal function, classical neuroleptics may also alter neurotransmission in the basal ganglia by enhancing dopamine receptor binding in the entopeduncular nucleus. © Rapid Communications of Oxford Ltd. |
| format |
JOUR |
| author |
Johnson, A.E. Coirini, H. Källström, L. Gunne, L.M. Wiesel, F.A. |
| author_facet |
Johnson, A.E. Coirini, H. Källström, L. Gunne, L.M. Wiesel, F.A. |
| author_sort |
Johnson, A.E. |
| title |
Neuroleptics differentially modulate central dopamine d1-receptor binding |
| title_short |
Neuroleptics differentially modulate central dopamine d1-receptor binding |
| title_full |
Neuroleptics differentially modulate central dopamine d1-receptor binding |
| title_fullStr |
Neuroleptics differentially modulate central dopamine d1-receptor binding |
| title_full_unstemmed |
Neuroleptics differentially modulate central dopamine d1-receptor binding |
| title_sort |
neuroleptics differentially modulate central dopamine d1-receptor binding |
| url |
http://hdl.handle.net/20.500.12110/paper_09594965_v6_n6_p933_Johnson |
| work_keys_str_mv |
AT johnsonae neurolepticsdifferentiallymodulatecentraldopamined1receptorbinding AT coirinih neurolepticsdifferentiallymodulatecentraldopamined1receptorbinding AT kallstroml neurolepticsdifferentiallymodulatecentraldopamined1receptorbinding AT gunnelm neurolepticsdifferentiallymodulatecentraldopamined1receptorbinding AT wieselfa neurolepticsdifferentiallymodulatecentraldopamined1receptorbinding |
| _version_ |
1782027387504951296 |