Characterization of dopamine receptor binding sites in the subthalamic nucleus
Experiments were undertaken to determine the distribution and binding profile of dopamine (DA) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (STh). Analysis of [l25I]NCQ-298 autoradiograms showed that binding sites of the D2-receptor family are abunda...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09594965_v5_n14_p1836_Johnson |
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todo:paper_09594965_v5_n14_p1836_Johnson2023-10-03T15:53:00Z Characterization of dopamine receptor binding sites in the subthalamic nucleus Johnson, A.E. Coirini, H. Källström, L. Wiesel, F.-A. Basal ganglia D1 receptors D2 receptors Dopamine Entopeduncular nucleus Extrapyramidal motor system Neuroleptics Subthalamic nucleus [125I]SCH-23982 [l25I]NCQ-298 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor dopamine 2 receptor eticlopride fluphenazine n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide neuroleptic agent raclopride animal tissue article autoradiography controlled study female nonhuman priority journal rat receptor binding subthalamic nucleus Animal Autoradiography Dopamine Agonists Dopamine Antagonists Female Iodine Radioisotopes Ligands Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Salicylamides Sch-23390 Support, Non-U.S. Gov't Thalamic Nuclei Experiments were undertaken to determine the distribution and binding profile of dopamine (DA) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (STh). Analysis of [l25I]NCQ-298 autoradiograms showed that binding sites of the D2-receptor family are abundant in the STh. Competition studies indicated that these sites were specifically of the D2 sub-type. However, contrary to previously published data, [l25I]SCH-23982 autoradiograms failed to reveal D1 receptor binding in the STh. These data suggest that DA acting at D2 receptors may directly modulate STh neural activity and furthermore that the antagonism of STh D2 receptor binding by neuroleptics may be involved in the expression of extrapyramidal motor disturbances. © Rapid Communications of Oxford Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09594965_v5_n14_p1836_Johnson |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Basal ganglia D1 receptors D2 receptors Dopamine Entopeduncular nucleus Extrapyramidal motor system Neuroleptics Subthalamic nucleus [125I]SCH-23982 [l25I]NCQ-298 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor dopamine 2 receptor eticlopride fluphenazine n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide neuroleptic agent raclopride animal tissue article autoradiography controlled study female nonhuman priority journal rat receptor binding subthalamic nucleus Animal Autoradiography Dopamine Agonists Dopamine Antagonists Female Iodine Radioisotopes Ligands Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Salicylamides Sch-23390 Support, Non-U.S. Gov't Thalamic Nuclei |
| spellingShingle |
Basal ganglia D1 receptors D2 receptors Dopamine Entopeduncular nucleus Extrapyramidal motor system Neuroleptics Subthalamic nucleus [125I]SCH-23982 [l25I]NCQ-298 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor dopamine 2 receptor eticlopride fluphenazine n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide neuroleptic agent raclopride animal tissue article autoradiography controlled study female nonhuman priority journal rat receptor binding subthalamic nucleus Animal Autoradiography Dopamine Agonists Dopamine Antagonists Female Iodine Radioisotopes Ligands Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Salicylamides Sch-23390 Support, Non-U.S. Gov't Thalamic Nuclei Johnson, A.E. Coirini, H. Källström, L. Wiesel, F.-A. Characterization of dopamine receptor binding sites in the subthalamic nucleus |
| topic_facet |
Basal ganglia D1 receptors D2 receptors Dopamine Entopeduncular nucleus Extrapyramidal motor system Neuroleptics Subthalamic nucleus [125I]SCH-23982 [l25I]NCQ-298 2 dipropylamino 7 hydroxytetralin 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate clozapine dopamine dopamine 1 receptor dopamine 2 receptor eticlopride fluphenazine n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide neuroleptic agent raclopride animal tissue article autoradiography controlled study female nonhuman priority journal rat receptor binding subthalamic nucleus Animal Autoradiography Dopamine Agonists Dopamine Antagonists Female Iodine Radioisotopes Ligands Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Dopamine D1 Receptors, Dopamine D2 Salicylamides Sch-23390 Support, Non-U.S. Gov't Thalamic Nuclei |
| description |
Experiments were undertaken to determine the distribution and binding profile of dopamine (DA) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (STh). Analysis of [l25I]NCQ-298 autoradiograms showed that binding sites of the D2-receptor family are abundant in the STh. Competition studies indicated that these sites were specifically of the D2 sub-type. However, contrary to previously published data, [l25I]SCH-23982 autoradiograms failed to reveal D1 receptor binding in the STh. These data suggest that DA acting at D2 receptors may directly modulate STh neural activity and furthermore that the antagonism of STh D2 receptor binding by neuroleptics may be involved in the expression of extrapyramidal motor disturbances. © Rapid Communications of Oxford Ltd. |
| format |
JOUR |
| author |
Johnson, A.E. Coirini, H. Källström, L. Wiesel, F.-A. |
| author_facet |
Johnson, A.E. Coirini, H. Källström, L. Wiesel, F.-A. |
| author_sort |
Johnson, A.E. |
| title |
Characterization of dopamine receptor binding sites in the subthalamic nucleus |
| title_short |
Characterization of dopamine receptor binding sites in the subthalamic nucleus |
| title_full |
Characterization of dopamine receptor binding sites in the subthalamic nucleus |
| title_fullStr |
Characterization of dopamine receptor binding sites in the subthalamic nucleus |
| title_full_unstemmed |
Characterization of dopamine receptor binding sites in the subthalamic nucleus |
| title_sort |
characterization of dopamine receptor binding sites in the subthalamic nucleus |
| url |
http://hdl.handle.net/20.500.12110/paper_09594965_v5_n14_p1836_Johnson |
| work_keys_str_mv |
AT johnsonae characterizationofdopaminereceptorbindingsitesinthesubthalamicnucleus AT coirinih characterizationofdopaminereceptorbindingsitesinthesubthalamicnucleus AT kallstroml characterizationofdopaminereceptorbindingsitesinthesubthalamicnucleus AT wieselfa characterizationofdopaminereceptorbindingsitesinthesubthalamicnucleus |
| _version_ |
1782028102715572224 |