Exogenous NGF alters a critical motor period in rat striatum

IN previous studies we found that there is a critical period during rat postnatal development when motor training starting at age 30 days (P30) but not before or after this age, induces a bilateral lifetime drop in B(max) of the muscarinic radioligand [3H]QNB in striatum. We examined the possibility...

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Autores principales: Wolansky, M.J., Cabrera, R.J., Ibarra, G.R., Monglat, L., Azcurra, J.M.
Formato: JOUR
Materias:
Circling
Development
mAchR
NGF
Plasticity
Rat Striatum
Training
nerve growth factor
animal experiment
animal model
article
brain maturation
circling behavior
controlled study
corpus striatum
ligand binding
motor performance
nerve cell plasticity
neurotransmission
neurotransmitter release
nonhuman
postnatal development
priority journal
rat
synaptic transmission
synaptogenesis
training
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09594965_v10_n13_p2705_Wolansky
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_09594965_v10_n13_p2705_Wolansky
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spelling todo:paper_09594965_v10_n13_p2705_Wolansky2023-10-03T15:52:58Z Exogenous NGF alters a critical motor period in rat striatum Wolansky, M.J. Cabrera, R.J. Ibarra, G.R. Monglat, L. Azcurra, J.M. Circling Development mAchR NGF Plasticity Rat Striatum Training nerve growth factor animal experiment animal model article brain maturation circling behavior controlled study corpus striatum ligand binding motor performance nerve cell plasticity neurotransmission neurotransmitter release nonhuman postnatal development priority journal rat synaptic transmission synaptogenesis training IN previous studies we found that there is a critical period during rat postnatal development when motor training starting at age 30 days (P30) but not before or after this age, induces a bilateral lifetime drop in B(max) of the muscarinic radioligand [3H]QNB in striatum. We examined the possibility that striatal NGF level would be a determining factor for the normal occurrence of this synaptic plasticity. With this aim, rats underwent training at P30-37 with or without simultaneous NGF perfusion into the left striatum. At P70, we found the expected bilateral enduring fall of striatal [3H]QNB sites in trained controls. While the non-cannulated side of NGF- treated trained rats showed a similar drop in [3H]QNB binding, the perfused striata from these animals were not affected by training. Thus, the findings add new evidence in favour of a major role of NGF in this critical period of activity-dependent permanent adjustment in the striatal muscarinic system. Fil:Wolansky, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Azcurra, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09594965_v10_n13_p2705_Wolansky
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Circling
Development
mAchR
NGF
Plasticity
Rat Striatum
Training
nerve growth factor
animal experiment
animal model
article
brain maturation
circling behavior
controlled study
corpus striatum
ligand binding
motor performance
nerve cell plasticity
neurotransmission
neurotransmitter release
nonhuman
postnatal development
priority journal
rat
synaptic transmission
synaptogenesis
training
spellingShingle Circling
Development
mAchR
NGF
Plasticity
Rat Striatum
Training
nerve growth factor
animal experiment
animal model
article
brain maturation
circling behavior
controlled study
corpus striatum
ligand binding
motor performance
nerve cell plasticity
neurotransmission
neurotransmitter release
nonhuman
postnatal development
priority journal
rat
synaptic transmission
synaptogenesis
training
Wolansky, M.J.
Cabrera, R.J.
Ibarra, G.R.
Monglat, L.
Azcurra, J.M.
Exogenous NGF alters a critical motor period in rat striatum
topic_facet Circling
Development
mAchR
NGF
Plasticity
Rat Striatum
Training
nerve growth factor
animal experiment
animal model
article
brain maturation
circling behavior
controlled study
corpus striatum
ligand binding
motor performance
nerve cell plasticity
neurotransmission
neurotransmitter release
nonhuman
postnatal development
priority journal
rat
synaptic transmission
synaptogenesis
training
description IN previous studies we found that there is a critical period during rat postnatal development when motor training starting at age 30 days (P30) but not before or after this age, induces a bilateral lifetime drop in B(max) of the muscarinic radioligand [3H]QNB in striatum. We examined the possibility that striatal NGF level would be a determining factor for the normal occurrence of this synaptic plasticity. With this aim, rats underwent training at P30-37 with or without simultaneous NGF perfusion into the left striatum. At P70, we found the expected bilateral enduring fall of striatal [3H]QNB sites in trained controls. While the non-cannulated side of NGF- treated trained rats showed a similar drop in [3H]QNB binding, the perfused striata from these animals were not affected by training. Thus, the findings add new evidence in favour of a major role of NGF in this critical period of activity-dependent permanent adjustment in the striatal muscarinic system.
format JOUR
author Wolansky, M.J.
Cabrera, R.J.
Ibarra, G.R.
Monglat, L.
Azcurra, J.M.
author_facet Wolansky, M.J.
Cabrera, R.J.
Ibarra, G.R.
Monglat, L.
Azcurra, J.M.
author_sort Wolansky, M.J.
title Exogenous NGF alters a critical motor period in rat striatum
title_short Exogenous NGF alters a critical motor period in rat striatum
title_full Exogenous NGF alters a critical motor period in rat striatum
title_fullStr Exogenous NGF alters a critical motor period in rat striatum
title_full_unstemmed Exogenous NGF alters a critical motor period in rat striatum
title_sort exogenous ngf alters a critical motor period in rat striatum
url http://hdl.handle.net/20.500.12110/paper_09594965_v10_n13_p2705_Wolansky
work_keys_str_mv AT wolanskymj exogenousngfaltersacriticalmotorperiodinratstriatum
AT cabrerarj exogenousngfaltersacriticalmotorperiodinratstriatum
AT ibarragr exogenousngfaltersacriticalmotorperiodinratstriatum
AT monglatl exogenousngfaltersacriticalmotorperiodinratstriatum
AT azcurrajm exogenousngfaltersacriticalmotorperiodinratstriatum
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