L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae

A search for bioactive compounds, inhibitors of Paenibacillus larvae, the causal agent of American foulbrood, a honeybees' disease, was carried on. Extracts of two fungal strains, Alternaria brassicicola and Alternaria raphani, isolated from pollen collected from beehives, exhibited a specific...

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Autores principales:	Gallardo, G.L., Peña, N.I., Chacana, P., Terzolo, H.R., Cabrera, G.M.
Formato:	JOUR
Materias:	Alternaria brassicicola Alternaria raphani American foulbrood L-Tenuazonic acid Paenibacillus larvae tetramic acids Alternaria Alternaria japonica Apis mellifera Bacteria (microorganisms) Paenibacillus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09593993_v20_n6_p609_Gallardo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_09593993_v20_n6_p609_Gallardo
record_format	dspace
spelling	todo:paper_09593993_v20_n6_p609_Gallardo2023-10-03T15:52:51Z L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae Gallardo, G.L. Peña, N.I. Chacana, P. Terzolo, H.R. Cabrera, G.M. Alternaria brassicicola Alternaria raphani American foulbrood L-Tenuazonic acid Paenibacillus larvae tetramic acids Alternaria Alternaria brassicicola Alternaria japonica Apis mellifera Bacteria (microorganisms) Paenibacillus Paenibacillus larvae A search for bioactive compounds, inhibitors of Paenibacillus larvae, the causal agent of American foulbrood, a honeybees' disease, was carried on. Extracts of two fungal strains, Alternaria brassicicola and Alternaria raphani, isolated from pollen collected from beehives, exhibited a specific inhibitory activity against this bacterium. From these extracts and by means of chromatographic steps and bioassay-guided fractionation, three tetramic acids were isolated. The compounds were identified by spectroscopic methods and the absolute stereochemistry was chemically determined. L-Tenuazonic acid was shown to be responsible for the antibiotic activity. This compound showed a MIC of 32 μg/ml, comparable with that of oxytetracycline, an antibiotic currently used for the prevention of American foulbrood. Fil:Gallardo, G.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cabrera, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09593993_v20_n6_p609_Gallardo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alternaria brassicicola Alternaria raphani American foulbrood L-Tenuazonic acid Paenibacillus larvae tetramic acids Alternaria Alternaria brassicicola Alternaria japonica Apis mellifera Bacteria (microorganisms) Paenibacillus Paenibacillus larvae
spellingShingle	Alternaria brassicicola Alternaria raphani American foulbrood L-Tenuazonic acid Paenibacillus larvae tetramic acids Alternaria Alternaria brassicicola Alternaria japonica Apis mellifera Bacteria (microorganisms) Paenibacillus Paenibacillus larvae Gallardo, G.L. Peña, N.I. Chacana, P. Terzolo, H.R. Cabrera, G.M. L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae
topic_facet	Alternaria brassicicola Alternaria raphani American foulbrood L-Tenuazonic acid Paenibacillus larvae tetramic acids Alternaria Alternaria brassicicola Alternaria japonica Apis mellifera Bacteria (microorganisms) Paenibacillus Paenibacillus larvae
description	A search for bioactive compounds, inhibitors of Paenibacillus larvae, the causal agent of American foulbrood, a honeybees' disease, was carried on. Extracts of two fungal strains, Alternaria brassicicola and Alternaria raphani, isolated from pollen collected from beehives, exhibited a specific inhibitory activity against this bacterium. From these extracts and by means of chromatographic steps and bioassay-guided fractionation, three tetramic acids were isolated. The compounds were identified by spectroscopic methods and the absolute stereochemistry was chemically determined. L-Tenuazonic acid was shown to be responsible for the antibiotic activity. This compound showed a MIC of 32 μg/ml, comparable with that of oxytetracycline, an antibiotic currently used for the prevention of American foulbrood.
format	JOUR
author	Gallardo, G.L. Peña, N.I. Chacana, P. Terzolo, H.R. Cabrera, G.M.
author_facet	Gallardo, G.L. Peña, N.I. Chacana, P. Terzolo, H.R. Cabrera, G.M.
author_sort	Gallardo, G.L.
title	L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae
title_short	L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae
title_full	L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae
title_fullStr	L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae
title_full_unstemmed	L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae
title_sort	l-tenuazonic acid, a new inhibitor of paenibacillus larvae
url	http://hdl.handle.net/20.500.12110/paper_09593993_v20_n6_p609_Gallardo
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L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae

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