Electronic nose screening of ethanol release during sol-gel encapsulation: A novel non-invasive method to test silica polymerisation
Porous silica matrices prepared by sol-gel process yield biocompatible materials adequate for encapsulation of biomolecules or drugs. The procedure is simple and fast, but when alkoxyde precursors like tetraethoxysilane (TEOS) are used the polymerisation reaction leads to the formation of alcohol as...
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todo:paper_09565663_v21_n6_p857_Lovino2023-10-03T15:52:08Z Electronic nose screening of ethanol release during sol-gel encapsulation: A novel non-invasive method to test silica polymerisation Lovino, M. Cardinal, M.F. Zubiri, D.B.V. Bernik, D.L. Controlled release matrices E-nose technology Encapsulation matrices Silica materials TEOS polymerisation Biomaterials Byproducts Drug dosage Hydrolysis Medical applications Polymerization Reaction kinetics Silica Sol-gels Controlled release matrices E-nose technology Encapsulation matrices Silica materials TEOS polymerisation Ethanol alcohol polymer silicon dioxide tetraethoxysilane theophylline aerosol article encapsulation gel hydrolysis polymerization precursor Biomimetics Coated Materials, Biocompatible Diffusion Drug Carriers Electrochemistry Ethanol Gases Materials Testing Phase Transition Porosity Silanes Silicon Dioxide Smell Transducers Porous silica matrices prepared by sol-gel process yield biocompatible materials adequate for encapsulation of biomolecules or drugs. The procedure is simple and fast, but when alkoxyde precursors like tetraethoxysilane (TEOS) are used the polymerisation reaction leads to the formation of alcohol as a by-product, which can produce undesirable effects on the activity of entrapped enzymes or modify a drug release kinetic. Therefore, it is critical to determine that no remnant ethanol is left prior using or storing the obtained biomaterial. In this regard, the technique used in the alcohol determination should be non-invasive and non-destructive to preserve the encapsulation device intact and ready to use. In this work we have successfully used a portable electronic nose (e-nose) for the screening of silica polymerisation process during theophylline encapsulation. TEOS reaction was "smelt" since precursor pre-hydrolysis until the end of ethanol release, sensed directly at the headspace of matrices slabs. Measurements showed that ethanol was negligible since 10th day in polymeric slabs of 10 mm width and 2 cm diameter. This first use of e-nose following a polymerisation reaction opens a wide number of putative applications in pharmaceutical and biochemical fields. © 2005 Elsevier B.V. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09565663_v21_n6_p857_Lovino |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Controlled release matrices E-nose technology Encapsulation matrices Silica materials TEOS polymerisation Biomaterials Byproducts Drug dosage Hydrolysis Medical applications Polymerization Reaction kinetics Silica Sol-gels Controlled release matrices E-nose technology Encapsulation matrices Silica materials TEOS polymerisation Ethanol alcohol polymer silicon dioxide tetraethoxysilane theophylline aerosol article encapsulation gel hydrolysis polymerization precursor Biomimetics Coated Materials, Biocompatible Diffusion Drug Carriers Electrochemistry Ethanol Gases Materials Testing Phase Transition Porosity Silanes Silicon Dioxide Smell Transducers |
| spellingShingle |
Controlled release matrices E-nose technology Encapsulation matrices Silica materials TEOS polymerisation Biomaterials Byproducts Drug dosage Hydrolysis Medical applications Polymerization Reaction kinetics Silica Sol-gels Controlled release matrices E-nose technology Encapsulation matrices Silica materials TEOS polymerisation Ethanol alcohol polymer silicon dioxide tetraethoxysilane theophylline aerosol article encapsulation gel hydrolysis polymerization precursor Biomimetics Coated Materials, Biocompatible Diffusion Drug Carriers Electrochemistry Ethanol Gases Materials Testing Phase Transition Porosity Silanes Silicon Dioxide Smell Transducers Lovino, M. Cardinal, M.F. Zubiri, D.B.V. Bernik, D.L. Electronic nose screening of ethanol release during sol-gel encapsulation: A novel non-invasive method to test silica polymerisation |
| topic_facet |
Controlled release matrices E-nose technology Encapsulation matrices Silica materials TEOS polymerisation Biomaterials Byproducts Drug dosage Hydrolysis Medical applications Polymerization Reaction kinetics Silica Sol-gels Controlled release matrices E-nose technology Encapsulation matrices Silica materials TEOS polymerisation Ethanol alcohol polymer silicon dioxide tetraethoxysilane theophylline aerosol article encapsulation gel hydrolysis polymerization precursor Biomimetics Coated Materials, Biocompatible Diffusion Drug Carriers Electrochemistry Ethanol Gases Materials Testing Phase Transition Porosity Silanes Silicon Dioxide Smell Transducers |
| description |
Porous silica matrices prepared by sol-gel process yield biocompatible materials adequate for encapsulation of biomolecules or drugs. The procedure is simple and fast, but when alkoxyde precursors like tetraethoxysilane (TEOS) are used the polymerisation reaction leads to the formation of alcohol as a by-product, which can produce undesirable effects on the activity of entrapped enzymes or modify a drug release kinetic. Therefore, it is critical to determine that no remnant ethanol is left prior using or storing the obtained biomaterial. In this regard, the technique used in the alcohol determination should be non-invasive and non-destructive to preserve the encapsulation device intact and ready to use. In this work we have successfully used a portable electronic nose (e-nose) for the screening of silica polymerisation process during theophylline encapsulation. TEOS reaction was "smelt" since precursor pre-hydrolysis until the end of ethanol release, sensed directly at the headspace of matrices slabs. Measurements showed that ethanol was negligible since 10th day in polymeric slabs of 10 mm width and 2 cm diameter. This first use of e-nose following a polymerisation reaction opens a wide number of putative applications in pharmaceutical and biochemical fields. © 2005 Elsevier B.V. All rights reserved. |
| format |
JOUR |
| author |
Lovino, M. Cardinal, M.F. Zubiri, D.B.V. Bernik, D.L. |
| author_facet |
Lovino, M. Cardinal, M.F. Zubiri, D.B.V. Bernik, D.L. |
| author_sort |
Lovino, M. |
| title |
Electronic nose screening of ethanol release during sol-gel encapsulation: A novel non-invasive method to test silica polymerisation |
| title_short |
Electronic nose screening of ethanol release during sol-gel encapsulation: A novel non-invasive method to test silica polymerisation |
| title_full |
Electronic nose screening of ethanol release during sol-gel encapsulation: A novel non-invasive method to test silica polymerisation |
| title_fullStr |
Electronic nose screening of ethanol release during sol-gel encapsulation: A novel non-invasive method to test silica polymerisation |
| title_full_unstemmed |
Electronic nose screening of ethanol release during sol-gel encapsulation: A novel non-invasive method to test silica polymerisation |
| title_sort |
electronic nose screening of ethanol release during sol-gel encapsulation: a novel non-invasive method to test silica polymerisation |
| url |
http://hdl.handle.net/20.500.12110/paper_09565663_v21_n6_p857_Lovino |
| work_keys_str_mv |
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| _version_ |
1782026220427280384 |