Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin

Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not a...

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Autores principales: Villamil, S.M., Alche, L.E., Coto, C.E.
Formato: JOUR
Materias:
Antiviral activity
HSV-1
Meliacine
Protein synthesis inhibition
meliacine
plant extract
unclassified drug
antiviral activity
article
controlled study
Herpes simplex virus 1
nonhuman
priority journal
protein synthesis inhibition
virus inhibition
virus replication
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09563202_v6_n4_p239_Villamil
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_09563202_v6_n4_p239_Villamil
record_format dspace
spelling todo:paper_09563202_v6_n4_p239_Villamil2023-10-03T15:51:55Z Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin Villamil, S.M. Alche, L.E. Coto, C.E. Antiviral activity HSV-1 Meliacine Protein synthesis inhibition meliacine plant extract unclassified drug antiviral activity article controlled study Herpes simplex virus 1 nonhuman priority journal protein synthesis inhibition virus inhibition virus replication Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not affect viral adsorption and penetration. Meliacine strongly inhibited specific infected-cell polypeptides (ICPs) produced late in infection. The antiviral activity, which is attributed mainly to this selective effect, was also demonstrated in an immunofluorescence assay. Fil:Alche, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09563202_v6_n4_p239_Villamil
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Antiviral activity
HSV-1
Meliacine
Protein synthesis inhibition
meliacine
plant extract
unclassified drug
antiviral activity
article
controlled study
Herpes simplex virus 1
nonhuman
priority journal
protein synthesis inhibition
virus inhibition
virus replication
spellingShingle Antiviral activity
HSV-1
Meliacine
Protein synthesis inhibition
meliacine
plant extract
unclassified drug
antiviral activity
article
controlled study
Herpes simplex virus 1
nonhuman
priority journal
protein synthesis inhibition
virus inhibition
virus replication
Villamil, S.M.
Alche, L.E.
Coto, C.E.
Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
topic_facet Antiviral activity
HSV-1
Meliacine
Protein synthesis inhibition
meliacine
plant extract
unclassified drug
antiviral activity
article
controlled study
Herpes simplex virus 1
nonhuman
priority journal
protein synthesis inhibition
virus inhibition
virus replication
description Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not affect viral adsorption and penetration. Meliacine strongly inhibited specific infected-cell polypeptides (ICPs) produced late in infection. The antiviral activity, which is attributed mainly to this selective effect, was also demonstrated in an immunofluorescence assay.
format JOUR
author Villamil, S.M.
Alche, L.E.
Coto, C.E.
author_facet Villamil, S.M.
Alche, L.E.
Coto, C.E.
author_sort Villamil, S.M.
title Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_short Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_full Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_fullStr Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_full_unstemmed Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
title_sort inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin
url http://hdl.handle.net/20.500.12110/paper_09563202_v6_n4_p239_Villamil
work_keys_str_mv AT villamilsm inhibitionofherpessimplexvirustype1multiplicationbymeliacineapeptideofplantorigin
AT alchele inhibitionofherpessimplexvirustype1multiplicationbymeliacineapeptideofplantorigin
AT cotoce inhibitionofherpessimplexvirustype1multiplicationbymeliacineapeptideofplantorigin
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