Evaluation of chemical and antiviral properties of essential oils from South American plants
The essential oils of seven aromatic plants from Córdoba, San Luis and San Juan Provinces (Argentina) were isolated by steam distillation and analysed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex...
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todo:paper_09563202_v16_n4_p247_Duschatzky2023-10-03T15:51:53Z Evaluation of chemical and antiviral properties of essential oils from South American plants Duschatzky, C.B. Possetto, M.L. Talarico, L.B. García, C.C. Michis, F. Almeida, N.V. De Lampasona, M.P. Schuff, C. Damonte, E.B. Dengue virus Essential oils Herpes simplex virus Junin virus South American plants Virus inactivation essential oil plant extract antiviral activity Argentina article Asteraceae Buddleja Buddleja cordobensis controlled study cytotoxicity Dengue virus drug isolation drug screening gas chromatography Herpes simplex virus 1 Heterothalamus alienus in vitro study Junin virus mass spectrometry medicinal plant nonhuman priority journal South America virion virus cell interaction virus inactivation virus inhibition virus strain The essential oils of seven aromatic plants from Córdoba, San Luis and San Juan Provinces (Argentina) were isolated by steam distillation and analysed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV) by a virucidal test. The oils showed a variable virucidal action according to the virus. The better relationship between cytotoxicity and anti-virus action was observed with the essential oils of Heterothalamus alienus and Buddleja cordobensis against JUNV, with virucidal concentration 50% (VC50) values of 44.2 and 39.0 ppm and therapeutic indices (cytotoxicity to virucidal activity ratio) of 3.3 and 4.0, respectively. The inhibitory action was exerted by a direct interaction of virions with the oils. Virions inactivated with B. cordobensis and H. alienus essential oil were not affected in their ability to bind to the host cell. The therapeutic indices shown by these essential oils in toto were very modest, but given the complexity of their chemical composition the future identification of the precise active principle may allow the elimination of cytotoxic components and increase the selectivity of the effective compound. ©2005 International Medical Press. Fil:Talarico, L.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:García, C.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09563202_v16_n4_p247_Duschatzky |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Dengue virus Essential oils Herpes simplex virus Junin virus South American plants Virus inactivation essential oil plant extract antiviral activity Argentina article Asteraceae Buddleja Buddleja cordobensis controlled study cytotoxicity Dengue virus drug isolation drug screening gas chromatography Herpes simplex virus 1 Heterothalamus alienus in vitro study Junin virus mass spectrometry medicinal plant nonhuman priority journal South America virion virus cell interaction virus inactivation virus inhibition virus strain |
| spellingShingle |
Dengue virus Essential oils Herpes simplex virus Junin virus South American plants Virus inactivation essential oil plant extract antiviral activity Argentina article Asteraceae Buddleja Buddleja cordobensis controlled study cytotoxicity Dengue virus drug isolation drug screening gas chromatography Herpes simplex virus 1 Heterothalamus alienus in vitro study Junin virus mass spectrometry medicinal plant nonhuman priority journal South America virion virus cell interaction virus inactivation virus inhibition virus strain Duschatzky, C.B. Possetto, M.L. Talarico, L.B. García, C.C. Michis, F. Almeida, N.V. De Lampasona, M.P. Schuff, C. Damonte, E.B. Evaluation of chemical and antiviral properties of essential oils from South American plants |
| topic_facet |
Dengue virus Essential oils Herpes simplex virus Junin virus South American plants Virus inactivation essential oil plant extract antiviral activity Argentina article Asteraceae Buddleja Buddleja cordobensis controlled study cytotoxicity Dengue virus drug isolation drug screening gas chromatography Herpes simplex virus 1 Heterothalamus alienus in vitro study Junin virus mass spectrometry medicinal plant nonhuman priority journal South America virion virus cell interaction virus inactivation virus inhibition virus strain |
| description |
The essential oils of seven aromatic plants from Córdoba, San Luis and San Juan Provinces (Argentina) were isolated by steam distillation and analysed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV) by a virucidal test. The oils showed a variable virucidal action according to the virus. The better relationship between cytotoxicity and anti-virus action was observed with the essential oils of Heterothalamus alienus and Buddleja cordobensis against JUNV, with virucidal concentration 50% (VC50) values of 44.2 and 39.0 ppm and therapeutic indices (cytotoxicity to virucidal activity ratio) of 3.3 and 4.0, respectively. The inhibitory action was exerted by a direct interaction of virions with the oils. Virions inactivated with B. cordobensis and H. alienus essential oil were not affected in their ability to bind to the host cell. The therapeutic indices shown by these essential oils in toto were very modest, but given the complexity of their chemical composition the future identification of the precise active principle may allow the elimination of cytotoxic components and increase the selectivity of the effective compound. ©2005 International Medical Press. |
| format |
JOUR |
| author |
Duschatzky, C.B. Possetto, M.L. Talarico, L.B. García, C.C. Michis, F. Almeida, N.V. De Lampasona, M.P. Schuff, C. Damonte, E.B. |
| author_facet |
Duschatzky, C.B. Possetto, M.L. Talarico, L.B. García, C.C. Michis, F. Almeida, N.V. De Lampasona, M.P. Schuff, C. Damonte, E.B. |
| author_sort |
Duschatzky, C.B. |
| title |
Evaluation of chemical and antiviral properties of essential oils from South American plants |
| title_short |
Evaluation of chemical and antiviral properties of essential oils from South American plants |
| title_full |
Evaluation of chemical and antiviral properties of essential oils from South American plants |
| title_fullStr |
Evaluation of chemical and antiviral properties of essential oils from South American plants |
| title_full_unstemmed |
Evaluation of chemical and antiviral properties of essential oils from South American plants |
| title_sort |
evaluation of chemical and antiviral properties of essential oils from south american plants |
| url |
http://hdl.handle.net/20.500.12110/paper_09563202_v16_n4_p247_Duschatzky |
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