Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing

Experience-related plasticity is an essential component of networks involved in early olfactory processing. However, the mechanisms and functions of plasticity in these neural networks are not well understood. We studied nonassociative plasticity by evaluating responses to two pure odors (A and X) a...

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Autores principales:	Locatelli, F.F., Fernandez, P.C., Villareal, F., Muezzinoglu, K., Huerta, R., Galizia, C.G., Smith, B.H.
Formato:	JOUR
Materias:	Antennal lobe Learning Olfaction Plasticity calcium adaptation animal cell animal experiment animal tissue antenna (organ) Apis mellifera article association behavioral science controlled study female mathematical model molecular imaging molecular interaction nerve cell inhibition nerve cell membrane potential nerve cell network nerve cell plasticity nerve projection nonhuman olfactory discrimination olfactory tract priority journal sensory stimulation stimulus response synaptic inhibition task performance Animals Arthropod Antennae Bees Calcium Signaling Female Ganglia, Invertebrate Membrane Potentials Models, Neurological Neuronal Plasticity Neurons Odors Olfactory Pathways Olfactory Perception Smell
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0953816X_v37_n1_p63_Locatelli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_0953816X_v37_n1_p63_Locatelli
record_format	dspace
spelling	todo:paper_0953816X_v37_n1_p63_Locatelli2023-10-03T15:51:20Z Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing Locatelli, F.F. Fernandez, P.C. Villareal, F. Muezzinoglu, K. Huerta, R. Galizia, C.G. Smith, B.H. Antennal lobe Learning Olfaction Plasticity calcium adaptation animal cell animal experiment animal tissue antenna (organ) Apis mellifera article association behavioral science controlled study female mathematical model molecular imaging molecular interaction nerve cell inhibition nerve cell membrane potential nerve cell network nerve cell plasticity nerve projection nonhuman olfactory discrimination olfactory tract priority journal sensory stimulation stimulus response synaptic inhibition task performance Animals Arthropod Antennae Bees Calcium Signaling Female Ganglia, Invertebrate Membrane Potentials Models, Neurological Neuronal Plasticity Neurons Odors Olfactory Pathways Olfactory Perception Smell Experience-related plasticity is an essential component of networks involved in early olfactory processing. However, the mechanisms and functions of plasticity in these neural networks are not well understood. We studied nonassociative plasticity by evaluating responses to two pure odors (A and X) and their binary mixture using calcium imaging of odor-elicited activity in output neurons of the honey bee antennal lobe. Unreinforced exposure to A or X produced no change in the neural response elicited by the pure odors. However, exposure to one odor (e.g. A) caused the response to the mixture to become more similar to that of the other component (X). We also show in behavioral analyses that unreinforced exposure to A caused the mixture to become perceptually more similar to X. These results suggest that nonassociative plasticity modifies neural networks in such a way that it affects local competitive interactions among mixture components. We used a computational model to evaluate the most likely targets for modification. Hebbian modification of synapses from inhibitory local interneurons to projection neurons most reliably produced the observed shift in response to the mixture. These results are consistent with a model in which the antennal lobe acts to filter olfactory information according to its relevance for performing a particular task. © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd. Fil:Locatelli, F.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fernandez, P.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0953816X_v37_n1_p63_Locatelli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antennal lobe Learning Olfaction Plasticity calcium adaptation animal cell animal experiment animal tissue antenna (organ) Apis mellifera article association behavioral science controlled study female mathematical model molecular imaging molecular interaction nerve cell inhibition nerve cell membrane potential nerve cell network nerve cell plasticity nerve projection nonhuman olfactory discrimination olfactory tract priority journal sensory stimulation stimulus response synaptic inhibition task performance Animals Arthropod Antennae Bees Calcium Signaling Female Ganglia, Invertebrate Membrane Potentials Models, Neurological Neuronal Plasticity Neurons Odors Olfactory Pathways Olfactory Perception Smell
spellingShingle	Antennal lobe Learning Olfaction Plasticity calcium adaptation animal cell animal experiment animal tissue antenna (organ) Apis mellifera article association behavioral science controlled study female mathematical model molecular imaging molecular interaction nerve cell inhibition nerve cell membrane potential nerve cell network nerve cell plasticity nerve projection nonhuman olfactory discrimination olfactory tract priority journal sensory stimulation stimulus response synaptic inhibition task performance Animals Arthropod Antennae Bees Calcium Signaling Female Ganglia, Invertebrate Membrane Potentials Models, Neurological Neuronal Plasticity Neurons Odors Olfactory Pathways Olfactory Perception Smell Locatelli, F.F. Fernandez, P.C. Villareal, F. Muezzinoglu, K. Huerta, R. Galizia, C.G. Smith, B.H. Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing
topic_facet	Antennal lobe Learning Olfaction Plasticity calcium adaptation animal cell animal experiment animal tissue antenna (organ) Apis mellifera article association behavioral science controlled study female mathematical model molecular imaging molecular interaction nerve cell inhibition nerve cell membrane potential nerve cell network nerve cell plasticity nerve projection nonhuman olfactory discrimination olfactory tract priority journal sensory stimulation stimulus response synaptic inhibition task performance Animals Arthropod Antennae Bees Calcium Signaling Female Ganglia, Invertebrate Membrane Potentials Models, Neurological Neuronal Plasticity Neurons Odors Olfactory Pathways Olfactory Perception Smell
description	Experience-related plasticity is an essential component of networks involved in early olfactory processing. However, the mechanisms and functions of plasticity in these neural networks are not well understood. We studied nonassociative plasticity by evaluating responses to two pure odors (A and X) and their binary mixture using calcium imaging of odor-elicited activity in output neurons of the honey bee antennal lobe. Unreinforced exposure to A or X produced no change in the neural response elicited by the pure odors. However, exposure to one odor (e.g. A) caused the response to the mixture to become more similar to that of the other component (X). We also show in behavioral analyses that unreinforced exposure to A caused the mixture to become perceptually more similar to X. These results suggest that nonassociative plasticity modifies neural networks in such a way that it affects local competitive interactions among mixture components. We used a computational model to evaluate the most likely targets for modification. Hebbian modification of synapses from inhibitory local interneurons to projection neurons most reliably produced the observed shift in response to the mixture. These results are consistent with a model in which the antennal lobe acts to filter olfactory information according to its relevance for performing a particular task. © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
format	JOUR
author	Locatelli, F.F. Fernandez, P.C. Villareal, F. Muezzinoglu, K. Huerta, R. Galizia, C.G. Smith, B.H.
author_facet	Locatelli, F.F. Fernandez, P.C. Villareal, F. Muezzinoglu, K. Huerta, R. Galizia, C.G. Smith, B.H.
author_sort	Locatelli, F.F.
title	Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing
title_short	Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing
title_full	Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing
title_fullStr	Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing
title_full_unstemmed	Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing
title_sort	nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing
url	http://hdl.handle.net/20.500.12110/paper_0953816X_v37_n1_p63_Locatelli
work_keys_str_mv	AT locatelliff nonassociativeplasticityalterscompetitiveinteractionsamongmixturecomponentsinearlyolfactoryprocessing AT fernandezpc nonassociativeplasticityalterscompetitiveinteractionsamongmixturecomponentsinearlyolfactoryprocessing AT villarealf nonassociativeplasticityalterscompetitiveinteractionsamongmixturecomponentsinearlyolfactoryprocessing AT muezzinogluk nonassociativeplasticityalterscompetitiveinteractionsamongmixturecomponentsinearlyolfactoryprocessing AT huertar nonassociativeplasticityalterscompetitiveinteractionsamongmixturecomponentsinearlyolfactoryprocessing AT galiziacg nonassociativeplasticityalterscompetitiveinteractionsamongmixturecomponentsinearlyolfactoryprocessing AT smithbh nonassociativeplasticityalterscompetitiveinteractionsamongmixturecomponentsinearlyolfactoryprocessing
_version_	1807319453008920576

Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing

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