In vitro and in vivo activity of eugenol on human herpesvirus

Eugenol (4-allyl-1-hydroxy-2-methoxybenzene) was tested for antiviral activity against HSV-1 and HSV-2 viruses. In vitro, it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti-HSV effects of eugenol were 25...

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Detalles Bibliográficos
Autores principales: Benencia, F., Courrges, M.C.
Formato: JOUR
Materias:
Acyclovir
Antiviral activity
Eugenol
Herpesvirus
Herpetic keratitis
aciclovir
eugenol
animal cell
animal experiment
animal model
antiviral activity
article
controlled study
cytotoxicity
drug mixture
drug potentiation
herpes simplex keratitis
Herpes simplex virus 1
Herpes simplex virus 2
Herpes virus infection
IC 50
mouse
nonhuman
phytotherapy
Vero cell
virus replication
Animals
Antiviral Agents
Cercopithecus aethiops
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Combinations
Herpes Simplex
Herpesvirus 1, Human
Herpesvirus 2, Human
Humans
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Vero Cells
Animalia
Herpes
Herpesviridae
Human herpesvirus 1
Human herpesvirus 2
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0951418X_v14_n7_p495_Benencia
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Eugenol (4-allyl-1-hydroxy-2-methoxybenzene) was tested for antiviral activity against HSV-1 and HSV-2 viruses. In vitro, it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti-HSV effects of eugenol were 25.6 μg/mL and 16.2 μg/mL for HSV-1 and HSV-2 respectively, 250 μg/mL being the maximum dose at which cytotoxicity was tested. Eugenol was virucidal and showed no cytotoxicity at the concentrations tested. Eugenol-acyclovir combinations synergistically inhibited herpesvirus replication in vitro. Topical application of eugenol delayed the development of herpesvirus induced keratitis in the mouse model. (C) 2000 John Wiley and Sons, Ltd.

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