Antiherpetic activity of s1, an algal derived sulphated galactan
The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/m...
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Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0951418X_v11_n8_p410_Pujol |
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todo:paper_0951418X_v11_n8_p410_Pujol2023-10-03T15:50:35Z Antiherpetic activity of s1, an algal derived sulphated galactan Pujol, C.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 μg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell. © 1996 by John Wiley & Sons, Ltd. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Errea, M.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0951418X_v11_n8_p410_Pujol |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment |
spellingShingle |
Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment Pujol, C.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. Antiherpetic activity of s1, an algal derived sulphated galactan |
topic_facet |
Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment |
description |
The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 μg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell. © 1996 by John Wiley & Sons, Ltd. |
format |
JOUR |
author |
Pujol, C.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. |
author_facet |
Pujol, C.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. |
author_sort |
Pujol, C.A. |
title |
Antiherpetic activity of s1, an algal derived sulphated galactan |
title_short |
Antiherpetic activity of s1, an algal derived sulphated galactan |
title_full |
Antiherpetic activity of s1, an algal derived sulphated galactan |
title_fullStr |
Antiherpetic activity of s1, an algal derived sulphated galactan |
title_full_unstemmed |
Antiherpetic activity of s1, an algal derived sulphated galactan |
title_sort |
antiherpetic activity of s1, an algal derived sulphated galactan |
url |
http://hdl.handle.net/20.500.12110/paper_0951418X_v11_n8_p410_Pujol |
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1782023787928092672 |