Antiherpetic activity of S1, an algal derived sulphated galactan
The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/m...
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todo:paper_0951418X_v10_n5_p410_Pujol2023-10-03T15:50:34Z Antiherpetic activity of S1, an algal derived sulphated galactan Pujol, C.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment antivirus agent galactane sulfate plant extract unclassified drug animal cell antiviral activity article concentration response controlled study cytotoxicity drug mechanism herpes simplex virus 1 herpes simplex virus 2 herpes virus host cell human human cell human cytomegalovirus nonhuman pseudorabies herpetovirus red alga virus adsorption algae Animalia Herpes Herpesviridae herpetovirus Human herpesvirus 1 Human herpesvirus 2 Human herpesvirus 5 Pterocladia Pterocladiella capillacea Rhodophyta Simplexvirus Suid herpesvirus 1 The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 μg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Errea, M.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0951418X_v10_n5_p410_Pujol |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment antivirus agent galactane sulfate plant extract unclassified drug animal cell antiviral activity article concentration response controlled study cytotoxicity drug mechanism herpes simplex virus 1 herpes simplex virus 2 herpes virus host cell human human cell human cytomegalovirus nonhuman pseudorabies herpetovirus red alga virus adsorption algae Animalia Herpes Herpesviridae herpetovirus Human herpesvirus 1 Human herpesvirus 2 Human herpesvirus 5 Pterocladia Pterocladiella capillacea Rhodophyta Simplexvirus Suid herpesvirus 1 |
spellingShingle |
Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment antivirus agent galactane sulfate plant extract unclassified drug animal cell antiviral activity article concentration response controlled study cytotoxicity drug mechanism herpes simplex virus 1 herpes simplex virus 2 herpes virus host cell human human cell human cytomegalovirus nonhuman pseudorabies herpetovirus red alga virus adsorption algae Animalia Herpes Herpesviridae herpetovirus Human herpesvirus 1 Human herpesvirus 2 Human herpesvirus 5 Pterocladia Pterocladiella capillacea Rhodophyta Simplexvirus Suid herpesvirus 1 Pujol, C.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. Antiherpetic activity of S1, an algal derived sulphated galactan |
topic_facet |
Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment antivirus agent galactane sulfate plant extract unclassified drug animal cell antiviral activity article concentration response controlled study cytotoxicity drug mechanism herpes simplex virus 1 herpes simplex virus 2 herpes virus host cell human human cell human cytomegalovirus nonhuman pseudorabies herpetovirus red alga virus adsorption algae Animalia Herpes Herpesviridae herpetovirus Human herpesvirus 1 Human herpesvirus 2 Human herpesvirus 5 Pterocladia Pterocladiella capillacea Rhodophyta Simplexvirus Suid herpesvirus 1 |
description |
The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 μg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell. |
format |
JOUR |
author |
Pujol, C.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. |
author_facet |
Pujol, C.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. |
author_sort |
Pujol, C.A. |
title |
Antiherpetic activity of S1, an algal derived sulphated galactan |
title_short |
Antiherpetic activity of S1, an algal derived sulphated galactan |
title_full |
Antiherpetic activity of S1, an algal derived sulphated galactan |
title_fullStr |
Antiherpetic activity of S1, an algal derived sulphated galactan |
title_full_unstemmed |
Antiherpetic activity of S1, an algal derived sulphated galactan |
title_sort |
antiherpetic activity of s1, an algal derived sulphated galactan |
url |
http://hdl.handle.net/20.500.12110/paper_0951418X_v10_n5_p410_Pujol |
work_keys_str_mv |
AT pujolca antiherpeticactivityofs1analgalderivedsulphatedgalactan AT erreami antiherpeticactivityofs1analgalderivedsulphatedgalactan AT matulewiczmc antiherpeticactivityofs1analgalderivedsulphatedgalactan AT damonteeb antiherpeticactivityofs1analgalderivedsulphatedgalactan |
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1782024938920607744 |