Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock
The segmentation clock is an oscillating genetic network thought to govern the rhythmic and sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the precursors of the segmented vertebral column. Understanding how the rhythmic signal arises, how it achieves precis...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09501991_v139_n4_p625_Oates |
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todo:paper_09501991_v139_n4_p625_Oates2023-10-03T15:49:58Z Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock Oates, A.C. Morelli, L.G. Ares, S. Gradient Modeling Negative feedback Oscillator Signaling Somitogenesis Notch receptor Wnt protein anatomy biological rhythm cell cycle arrest cell synchronization embryo segmentation gene expression gene mutation mathematical model molecular dynamics molecular genetics molecular mechanics nonhuman oscillation periodicity priority journal review signal transduction somite steady state Animals Biological Clocks Biological Evolution Body Patterning CLOCK Proteins Embryonic Development Gene Expression Regulation, Developmental Models, Theoretical Receptors, Notch Receptors, Opioid, delta Signal Transduction Somites Vertebrates Wnt Proteins Vertebrata The segmentation clock is an oscillating genetic network thought to govern the rhythmic and sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the precursors of the segmented vertebral column. Understanding how the rhythmic signal arises, how it achieves precision and how it patterns the embryo remain challenging issues. Recent work has provided evidence of how the period of the segmentation clock is regulated and how this affects the anatomy of the embryo. The ongoing development of realtime clock reporters and mathematical models promise novel insight into the dynamic behavior of the clock. © 2012. Published by The Company of Biologists Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09501991_v139_n4_p625_Oates |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Gradient Modeling Negative feedback Oscillator Signaling Somitogenesis Notch receptor Wnt protein anatomy biological rhythm cell cycle arrest cell synchronization embryo segmentation gene expression gene mutation mathematical model molecular dynamics molecular genetics molecular mechanics nonhuman oscillation periodicity priority journal review signal transduction somite steady state Animals Biological Clocks Biological Evolution Body Patterning CLOCK Proteins Embryonic Development Gene Expression Regulation, Developmental Models, Theoretical Receptors, Notch Receptors, Opioid, delta Signal Transduction Somites Vertebrates Wnt Proteins Vertebrata |
| spellingShingle |
Gradient Modeling Negative feedback Oscillator Signaling Somitogenesis Notch receptor Wnt protein anatomy biological rhythm cell cycle arrest cell synchronization embryo segmentation gene expression gene mutation mathematical model molecular dynamics molecular genetics molecular mechanics nonhuman oscillation periodicity priority journal review signal transduction somite steady state Animals Biological Clocks Biological Evolution Body Patterning CLOCK Proteins Embryonic Development Gene Expression Regulation, Developmental Models, Theoretical Receptors, Notch Receptors, Opioid, delta Signal Transduction Somites Vertebrates Wnt Proteins Vertebrata Oates, A.C. Morelli, L.G. Ares, S. Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock |
| topic_facet |
Gradient Modeling Negative feedback Oscillator Signaling Somitogenesis Notch receptor Wnt protein anatomy biological rhythm cell cycle arrest cell synchronization embryo segmentation gene expression gene mutation mathematical model molecular dynamics molecular genetics molecular mechanics nonhuman oscillation periodicity priority journal review signal transduction somite steady state Animals Biological Clocks Biological Evolution Body Patterning CLOCK Proteins Embryonic Development Gene Expression Regulation, Developmental Models, Theoretical Receptors, Notch Receptors, Opioid, delta Signal Transduction Somites Vertebrates Wnt Proteins Vertebrata |
| description |
The segmentation clock is an oscillating genetic network thought to govern the rhythmic and sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the precursors of the segmented vertebral column. Understanding how the rhythmic signal arises, how it achieves precision and how it patterns the embryo remain challenging issues. Recent work has provided evidence of how the period of the segmentation clock is regulated and how this affects the anatomy of the embryo. The ongoing development of realtime clock reporters and mathematical models promise novel insight into the dynamic behavior of the clock. © 2012. Published by The Company of Biologists Ltd. |
| format |
JOUR |
| author |
Oates, A.C. Morelli, L.G. Ares, S. |
| author_facet |
Oates, A.C. Morelli, L.G. Ares, S. |
| author_sort |
Oates, A.C. |
| title |
Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock |
| title_short |
Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock |
| title_full |
Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock |
| title_fullStr |
Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock |
| title_full_unstemmed |
Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock |
| title_sort |
patterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock |
| url |
http://hdl.handle.net/20.500.12110/paper_09501991_v139_n4_p625_Oates |
| work_keys_str_mv |
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