Synthesis and NMR Studies of Some Steroidal Isoxazoles

A short synthesis of 17α-pregna-2,4-dien-[2,3-d]isoxazol-17β-ol (1) is described using mild reaction conditions and with a high overall yield. The equilibrium between keto-enolic forms has been studied by 1H NMR methods. Complete assignments o f all the resonances in the 1H and 16C NMR spectra o f D...

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Autores principales: Giacopello, S., Deluca, M.E., Seldes, A.M.
Formato: JOUR
Materias:
17α-Pregna-2,4-dien-[2,3-d]isoxazol-17β-ol, Synthesis, NMR Spectra
Anabolic Agents
Isoxazolinic Steroids
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09320776_v47_n6_p891_Giacopello
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_09320776_v47_n6_p891_Giacopello
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spelling todo:paper_09320776_v47_n6_p891_Giacopello2023-10-03T15:48:27Z Synthesis and NMR Studies of Some Steroidal Isoxazoles Giacopello, S. Deluca, M.E. Seldes, A.M. 17α-Pregna-2,4-dien-[2,3-d]isoxazol-17β-ol, Synthesis, NMR Spectra Anabolic Agents Isoxazolinic Steroids A short synthesis of 17α-pregna-2,4-dien-[2,3-d]isoxazol-17β-ol (1) is described using mild reaction conditions and with a high overall yield. The equilibrium between keto-enolic forms has been studied by 1H NMR methods. Complete assignments o f all the resonances in the 1H and 16C NMR spectra o f Danazol have been made using a variety o f one and two-dimensional correlation methods. 13C NMR spectra of all the intermediate and related model compounds were also assigned. © 1992, Walter de Gruyter. All rights reserved. Fil:Giacopello, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Deluca, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Seldes, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09320776_v47_n6_p891_Giacopello
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 17α-Pregna-2,4-dien-[2,3-d]isoxazol-17β-ol, Synthesis, NMR Spectra
Anabolic Agents
Isoxazolinic Steroids
spellingShingle 17α-Pregna-2,4-dien-[2,3-d]isoxazol-17β-ol, Synthesis, NMR Spectra
Anabolic Agents
Isoxazolinic Steroids
Giacopello, S.
Deluca, M.E.
Seldes, A.M.
Synthesis and NMR Studies of Some Steroidal Isoxazoles
topic_facet 17α-Pregna-2,4-dien-[2,3-d]isoxazol-17β-ol, Synthesis, NMR Spectra
Anabolic Agents
Isoxazolinic Steroids
description A short synthesis of 17α-pregna-2,4-dien-[2,3-d]isoxazol-17β-ol (1) is described using mild reaction conditions and with a high overall yield. The equilibrium between keto-enolic forms has been studied by 1H NMR methods. Complete assignments o f all the resonances in the 1H and 16C NMR spectra o f Danazol have been made using a variety o f one and two-dimensional correlation methods. 13C NMR spectra of all the intermediate and related model compounds were also assigned. © 1992, Walter de Gruyter. All rights reserved.
format JOUR
author Giacopello, S.
Deluca, M.E.
Seldes, A.M.
author_facet Giacopello, S.
Deluca, M.E.
Seldes, A.M.
author_sort Giacopello, S.
title Synthesis and NMR Studies of Some Steroidal Isoxazoles
title_short Synthesis and NMR Studies of Some Steroidal Isoxazoles
title_full Synthesis and NMR Studies of Some Steroidal Isoxazoles
title_fullStr Synthesis and NMR Studies of Some Steroidal Isoxazoles
title_full_unstemmed Synthesis and NMR Studies of Some Steroidal Isoxazoles
title_sort synthesis and nmr studies of some steroidal isoxazoles
url http://hdl.handle.net/20.500.12110/paper_09320776_v47_n6_p891_Giacopello
work_keys_str_mv AT giacopellos synthesisandnmrstudiesofsomesteroidalisoxazoles
AT delucame synthesisandnmrstudiesofsomesteroidalisoxazoles
AT seldesam synthesisandnmrstudiesofsomesteroidalisoxazoles
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