Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection
Infection with Trypanosoma cruzi develops in three phases: acute, indeterminate or asymptomatic, and chronic phase (with cardiac or digestive manifestations). Moreover, transmission may occur from infected mothers to newborn, the so-called congenital form. In the present study, humoral responses aga...
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todo:paper_09288244_v12_n3-4_p231_Aznar2023-10-03T15:47:30Z Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection Aznar, C. Lopez-Bergami, P. Brandariz, S. Mariette, C. Liegeard, P. Alves, M.d.C.d.D. Barreiro, E.L. Carrasco, R. Lafon, S. Kaplan, D. Miguez, H. Camacho, C. Levitus, G. Mariano Levin, J. Hontebeyrie, M. Chagas disease diagnosis Chagasic cardiomyopathy Myocardites Ribosomal P protein Synthetic peptide Trypanosoma cruzi immunoglobulin m parasite antibody adult article blood donor cardiomyopathy chagas disease congenital infection controlled study human major clinical study newborn priority journal trypanosoma cruzi trypanosomiasis Acute Disease Animal Antibodies, Protozoan Argentina Base Sequence Blood Donors Brazil Chagas Cardiomyopathy Chagas Disease Chronic Disease Diagnosis, Differential Human Immunoglobulin Isotypes Infant, Newborn Molecular Sequence Data Ribosomal Proteins Seroepidemiologic Studies Trypanosoma cruzi Infection with Trypanosoma cruzi develops in three phases: acute, indeterminate or asymptomatic, and chronic phase (with cardiac or digestive manifestations). Moreover, transmission may occur from infected mothers to newborn, the so-called congenital form. In the present study, humoral responses against T. cruzi total extract and against the 13 amino acid peptide named R-13 derived from the parasite ribosomal P protein, previously described as a possible marker of chronic Chagas heart disease, were determined pateints and in blood bank donors from endemic areas. While in sera from acute phase, only IgM anti-T.cruzi response was observed, both IgM and IgG anti-T. cruzi antibodies were detected in sera from congenitally infected newborns. The percentage of positive response in sera from blood bank donors was relatively high in endemic regions. Antibodies against the R-13 peptide were present in a large proportion of cardiac chagasic patients but were totally lacking in patients with digestive form of Chagas' disease. Furthermore, anti-R-13 positive responses were detected in congenitally infected newborns. © 1995. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09288244_v12_n3-4_p231_Aznar |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Chagas disease diagnosis Chagasic cardiomyopathy Myocardites Ribosomal P protein Synthetic peptide Trypanosoma cruzi immunoglobulin m parasite antibody adult article blood donor cardiomyopathy chagas disease congenital infection controlled study human major clinical study newborn priority journal trypanosoma cruzi trypanosomiasis Acute Disease Animal Antibodies, Protozoan Argentina Base Sequence Blood Donors Brazil Chagas Cardiomyopathy Chagas Disease Chronic Disease Diagnosis, Differential Human Immunoglobulin Isotypes Infant, Newborn Molecular Sequence Data Ribosomal Proteins Seroepidemiologic Studies Trypanosoma cruzi |
| spellingShingle |
Chagas disease diagnosis Chagasic cardiomyopathy Myocardites Ribosomal P protein Synthetic peptide Trypanosoma cruzi immunoglobulin m parasite antibody adult article blood donor cardiomyopathy chagas disease congenital infection controlled study human major clinical study newborn priority journal trypanosoma cruzi trypanosomiasis Acute Disease Animal Antibodies, Protozoan Argentina Base Sequence Blood Donors Brazil Chagas Cardiomyopathy Chagas Disease Chronic Disease Diagnosis, Differential Human Immunoglobulin Isotypes Infant, Newborn Molecular Sequence Data Ribosomal Proteins Seroepidemiologic Studies Trypanosoma cruzi Aznar, C. Lopez-Bergami, P. Brandariz, S. Mariette, C. Liegeard, P. Alves, M.d.C.d.D. Barreiro, E.L. Carrasco, R. Lafon, S. Kaplan, D. Miguez, H. Camacho, C. Levitus, G. Mariano Levin, J. Hontebeyrie, M. Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection |
| topic_facet |
Chagas disease diagnosis Chagasic cardiomyopathy Myocardites Ribosomal P protein Synthetic peptide Trypanosoma cruzi immunoglobulin m parasite antibody adult article blood donor cardiomyopathy chagas disease congenital infection controlled study human major clinical study newborn priority journal trypanosoma cruzi trypanosomiasis Acute Disease Animal Antibodies, Protozoan Argentina Base Sequence Blood Donors Brazil Chagas Cardiomyopathy Chagas Disease Chronic Disease Diagnosis, Differential Human Immunoglobulin Isotypes Infant, Newborn Molecular Sequence Data Ribosomal Proteins Seroepidemiologic Studies Trypanosoma cruzi |
| description |
Infection with Trypanosoma cruzi develops in three phases: acute, indeterminate or asymptomatic, and chronic phase (with cardiac or digestive manifestations). Moreover, transmission may occur from infected mothers to newborn, the so-called congenital form. In the present study, humoral responses against T. cruzi total extract and against the 13 amino acid peptide named R-13 derived from the parasite ribosomal P protein, previously described as a possible marker of chronic Chagas heart disease, were determined pateints and in blood bank donors from endemic areas. While in sera from acute phase, only IgM anti-T.cruzi response was observed, both IgM and IgG anti-T. cruzi antibodies were detected in sera from congenitally infected newborns. The percentage of positive response in sera from blood bank donors was relatively high in endemic regions. Antibodies against the R-13 peptide were present in a large proportion of cardiac chagasic patients but were totally lacking in patients with digestive form of Chagas' disease. Furthermore, anti-R-13 positive responses were detected in congenitally infected newborns. © 1995. |
| format |
JOUR |
| author |
Aznar, C. Lopez-Bergami, P. Brandariz, S. Mariette, C. Liegeard, P. Alves, M.d.C.d.D. Barreiro, E.L. Carrasco, R. Lafon, S. Kaplan, D. Miguez, H. Camacho, C. Levitus, G. Mariano Levin, J. Hontebeyrie, M. |
| author_facet |
Aznar, C. Lopez-Bergami, P. Brandariz, S. Mariette, C. Liegeard, P. Alves, M.d.C.d.D. Barreiro, E.L. Carrasco, R. Lafon, S. Kaplan, D. Miguez, H. Camacho, C. Levitus, G. Mariano Levin, J. Hontebeyrie, M. |
| author_sort |
Aznar, C. |
| title |
Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection |
| title_short |
Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection |
| title_full |
Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection |
| title_fullStr |
Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection |
| title_full_unstemmed |
Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection |
| title_sort |
prevalence of anti-r-13 antibodies in human trypanosoma cruzi infection |
| url |
http://hdl.handle.net/20.500.12110/paper_09288244_v12_n3-4_p231_Aznar |
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