Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes

Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like a...

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Detalles Bibliográficos
Autores principales: Tosato, M.G., Maya Girón, J.V., Martin, A.A., Krishna Tippavajhala, V., Fernández Lorenzo de Mele, M., Dicelio, L.
Formato: JOUR
Materias:
Confocal Raman spectroscopy
Liposomes
Nanoparticles
Resveratrol
Transdermal drug delivery
Calorimetry
Controlled drug delivery
Deformation
Dynamic light scattering
Hydrophobicity
Phospholipids
Raman spectroscopy
Anticancer properties
Conformational change
Reduced permeabilities
Structural characterization
Therapeutic potentials
Transdermal drug delivery systems
Targeted drug delivery
alcohol
liposome
nanoparticle
polysorbate
resveratrol
stilbene derivative
chemistry
cutaneous drug administration
drug delivery system
photon correlation spectroscopy
procedures
Raman spectrometry
skin absorption
transmission electron microscopy
Administration, Cutaneous
Drug Delivery Systems
Dynamic Light Scattering
Ethanol
Microscopy, Electron, Transmission
Polysorbates
Skin Absorption
Spectrum Analysis, Raman
Stilbenes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09284931_v90_n_p356_Tosato
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like avoiding gastrointestinal problems and first pass metabolism. However, its therapeutic potential is limited by its low solubility and low stability in water and the reduced permeability of stratum corneum. To overcome these inconveniences the encapsulation of this compound in a drug delivery system is proposed here. In order to find the best carrier for transdermal application of RSV various liposomal nanoparticulate carriers like conventional liposomes (L-RSV), deformable liposomes (LD-RSV), ultradeformable liposomes (LUD-RSV) and ethosomes (Etho-RSV) were assayed. Transmission electron microscopic (TEM) and dynamic light scattering (DLS) studies were performed to analyze the surface morphology of these carriers. Structural characterization for these formulations was performed by confocal Raman spectroscopy. The spectroscopic results were analysed in conjunction with calorimetric data to identify the conformational changes and stability of formulations in the different nanoparticles induced by the presence of RSV. Comparison of the results obtained with the different carrier systems (L-RSV, LD-RSV, LUD-RSV and Etho-RSV) revealed that the best RSV carrier was LD-RSV. The increase in the fluidity of the bilayers in the region of the hydrophobic chains of the phospholipid by ethanol probably facilitates the accommodation of the RSV in the bilayer and contributes to the improved encapsulation of RSV without affecting the mobility of this carrier. © 2018 Elsevier B.V.

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