Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes
Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like a...
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todo:paper_09284931_v90_n_p356_Tosato2023-10-03T15:47:29Z Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes Tosato, M.G. Maya Girón, J.V. Martin, A.A. Krishna Tippavajhala, V. Fernández Lorenzo de Mele, M. Dicelio, L. Confocal Raman spectroscopy Liposomes Nanoparticles Resveratrol Transdermal drug delivery Calorimetry Controlled drug delivery Deformation Dynamic light scattering Hydrophobicity Liposomes Nanoparticles Phospholipids Raman spectroscopy Resveratrol Anticancer properties Confocal Raman spectroscopy Conformational change Reduced permeabilities Structural characterization Therapeutic potentials Transdermal drug delivery Transdermal drug delivery systems Targeted drug delivery alcohol liposome nanoparticle polysorbate resveratrol stilbene derivative chemistry cutaneous drug administration drug delivery system photon correlation spectroscopy procedures Raman spectrometry skin absorption transmission electron microscopy Administration, Cutaneous Drug Delivery Systems Dynamic Light Scattering Ethanol Liposomes Microscopy, Electron, Transmission Nanoparticles Polysorbates Skin Absorption Spectrum Analysis, Raman Stilbenes Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like avoiding gastrointestinal problems and first pass metabolism. However, its therapeutic potential is limited by its low solubility and low stability in water and the reduced permeability of stratum corneum. To overcome these inconveniences the encapsulation of this compound in a drug delivery system is proposed here. In order to find the best carrier for transdermal application of RSV various liposomal nanoparticulate carriers like conventional liposomes (L-RSV), deformable liposomes (LD-RSV), ultradeformable liposomes (LUD-RSV) and ethosomes (Etho-RSV) were assayed. Transmission electron microscopic (TEM) and dynamic light scattering (DLS) studies were performed to analyze the surface morphology of these carriers. Structural characterization for these formulations was performed by confocal Raman spectroscopy. The spectroscopic results were analysed in conjunction with calorimetric data to identify the conformational changes and stability of formulations in the different nanoparticles induced by the presence of RSV. Comparison of the results obtained with the different carrier systems (L-RSV, LD-RSV, LUD-RSV and Etho-RSV) revealed that the best RSV carrier was LD-RSV. The increase in the fluidity of the bilayers in the region of the hydrophobic chains of the phospholipid by ethanol probably facilitates the accommodation of the RSV in the bilayer and contributes to the improved encapsulation of RSV without affecting the mobility of this carrier. © 2018 Elsevier B.V. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09284931_v90_n_p356_Tosato |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Confocal Raman spectroscopy Liposomes Nanoparticles Resveratrol Transdermal drug delivery Calorimetry Controlled drug delivery Deformation Dynamic light scattering Hydrophobicity Liposomes Nanoparticles Phospholipids Raman spectroscopy Resveratrol Anticancer properties Confocal Raman spectroscopy Conformational change Reduced permeabilities Structural characterization Therapeutic potentials Transdermal drug delivery Transdermal drug delivery systems Targeted drug delivery alcohol liposome nanoparticle polysorbate resveratrol stilbene derivative chemistry cutaneous drug administration drug delivery system photon correlation spectroscopy procedures Raman spectrometry skin absorption transmission electron microscopy Administration, Cutaneous Drug Delivery Systems Dynamic Light Scattering Ethanol Liposomes Microscopy, Electron, Transmission Nanoparticles Polysorbates Skin Absorption Spectrum Analysis, Raman Stilbenes |
| spellingShingle |
Confocal Raman spectroscopy Liposomes Nanoparticles Resveratrol Transdermal drug delivery Calorimetry Controlled drug delivery Deformation Dynamic light scattering Hydrophobicity Liposomes Nanoparticles Phospholipids Raman spectroscopy Resveratrol Anticancer properties Confocal Raman spectroscopy Conformational change Reduced permeabilities Structural characterization Therapeutic potentials Transdermal drug delivery Transdermal drug delivery systems Targeted drug delivery alcohol liposome nanoparticle polysorbate resveratrol stilbene derivative chemistry cutaneous drug administration drug delivery system photon correlation spectroscopy procedures Raman spectrometry skin absorption transmission electron microscopy Administration, Cutaneous Drug Delivery Systems Dynamic Light Scattering Ethanol Liposomes Microscopy, Electron, Transmission Nanoparticles Polysorbates Skin Absorption Spectrum Analysis, Raman Stilbenes Tosato, M.G. Maya Girón, J.V. Martin, A.A. Krishna Tippavajhala, V. Fernández Lorenzo de Mele, M. Dicelio, L. Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes |
| topic_facet |
Confocal Raman spectroscopy Liposomes Nanoparticles Resveratrol Transdermal drug delivery Calorimetry Controlled drug delivery Deformation Dynamic light scattering Hydrophobicity Liposomes Nanoparticles Phospholipids Raman spectroscopy Resveratrol Anticancer properties Confocal Raman spectroscopy Conformational change Reduced permeabilities Structural characterization Therapeutic potentials Transdermal drug delivery Transdermal drug delivery systems Targeted drug delivery alcohol liposome nanoparticle polysorbate resveratrol stilbene derivative chemistry cutaneous drug administration drug delivery system photon correlation spectroscopy procedures Raman spectrometry skin absorption transmission electron microscopy Administration, Cutaneous Drug Delivery Systems Dynamic Light Scattering Ethanol Liposomes Microscopy, Electron, Transmission Nanoparticles Polysorbates Skin Absorption Spectrum Analysis, Raman Stilbenes |
| description |
Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like avoiding gastrointestinal problems and first pass metabolism. However, its therapeutic potential is limited by its low solubility and low stability in water and the reduced permeability of stratum corneum. To overcome these inconveniences the encapsulation of this compound in a drug delivery system is proposed here. In order to find the best carrier for transdermal application of RSV various liposomal nanoparticulate carriers like conventional liposomes (L-RSV), deformable liposomes (LD-RSV), ultradeformable liposomes (LUD-RSV) and ethosomes (Etho-RSV) were assayed. Transmission electron microscopic (TEM) and dynamic light scattering (DLS) studies were performed to analyze the surface morphology of these carriers. Structural characterization for these formulations was performed by confocal Raman spectroscopy. The spectroscopic results were analysed in conjunction with calorimetric data to identify the conformational changes and stability of formulations in the different nanoparticles induced by the presence of RSV. Comparison of the results obtained with the different carrier systems (L-RSV, LD-RSV, LUD-RSV and Etho-RSV) revealed that the best RSV carrier was LD-RSV. The increase in the fluidity of the bilayers in the region of the hydrophobic chains of the phospholipid by ethanol probably facilitates the accommodation of the RSV in the bilayer and contributes to the improved encapsulation of RSV without affecting the mobility of this carrier. © 2018 Elsevier B.V. |
| format |
JOUR |
| author |
Tosato, M.G. Maya Girón, J.V. Martin, A.A. Krishna Tippavajhala, V. Fernández Lorenzo de Mele, M. Dicelio, L. |
| author_facet |
Tosato, M.G. Maya Girón, J.V. Martin, A.A. Krishna Tippavajhala, V. Fernández Lorenzo de Mele, M. Dicelio, L. |
| author_sort |
Tosato, M.G. |
| title |
Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes |
| title_short |
Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes |
| title_full |
Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes |
| title_fullStr |
Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes |
| title_full_unstemmed |
Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes |
| title_sort |
comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes |
| url |
http://hdl.handle.net/20.500.12110/paper_09284931_v90_n_p356_Tosato |
| work_keys_str_mv |
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1782029745748180992 |