The efferent medial olivocochlear-hair cell synapse

Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elgoyhen, A.B., Katz, E.
Formato:	JOUR
Materias:	α9 and α10 Nicotinic receptors Cochlea Hair cells Nicotinic receptors Prestin SK channels Synaptic plasticity acetylcholine ion channel nicotinic receptor nicotinic receptor alpha10 nicotinic receptor alpha9 prestin small conductance calcium activated potassium channel unclassified drug acetylcholine release article auditory stimulation calcium cell level cell activation cell function cell interaction cell motility cochlear nerve efferent nerve hair cell human hyperpolarization intracellular signaling membrane permeability nerve cell inhibition nerve cell plasticity nonhuman olivary nucleus olivocochlear hair cell potassium current signal processing sound transmission synapse synaptic transmission vibration Animals Efferent Pathways Hair Cells, Auditory Humans Olivary Nucleus Receptors, Nicotinic Synapses
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09284257_v106_n1-2_p47_Elgoyhen
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_09284257_v106_n1-2_p47_Elgoyhen
record_format	dspace
spelling	todo:paper_09284257_v106_n1-2_p47_Elgoyhen2023-10-03T15:47:21Z The efferent medial olivocochlear-hair cell synapse Elgoyhen, A.B. Katz, E. α9 and α10 Nicotinic receptors Cochlea Hair cells Nicotinic receptors Prestin SK channels Synaptic plasticity acetylcholine ion channel nicotinic receptor nicotinic receptor alpha10 nicotinic receptor alpha9 prestin small conductance calcium activated potassium channel unclassified drug acetylcholine release article auditory stimulation calcium cell level cell activation cell function cell interaction cell motility cochlear nerve efferent nerve hair cell human hyperpolarization intracellular signaling membrane permeability nerve cell inhibition nerve cell plasticity nonhuman olivary nucleus olivocochlear hair cell potassium current signal processing sound transmission synapse synaptic transmission vibration Animals Cochlea Efferent Pathways Hair Cells, Auditory Humans Olivary Nucleus Receptors, Nicotinic Synapses Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca 2+ permeable and is coupled to a Ca 2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse. © 2011 Elsevier Ltd. Fil:Katz, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09284257_v106_n1-2_p47_Elgoyhen
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	α9 and α10 Nicotinic receptors Cochlea Hair cells Nicotinic receptors Prestin SK channels Synaptic plasticity acetylcholine ion channel nicotinic receptor nicotinic receptor alpha10 nicotinic receptor alpha9 prestin small conductance calcium activated potassium channel unclassified drug acetylcholine release article auditory stimulation calcium cell level cell activation cell function cell interaction cell motility cochlear nerve efferent nerve hair cell human hyperpolarization intracellular signaling membrane permeability nerve cell inhibition nerve cell plasticity nonhuman olivary nucleus olivocochlear hair cell potassium current signal processing sound transmission synapse synaptic transmission vibration Animals Cochlea Efferent Pathways Hair Cells, Auditory Humans Olivary Nucleus Receptors, Nicotinic Synapses
spellingShingle	α9 and α10 Nicotinic receptors Cochlea Hair cells Nicotinic receptors Prestin SK channels Synaptic plasticity acetylcholine ion channel nicotinic receptor nicotinic receptor alpha10 nicotinic receptor alpha9 prestin small conductance calcium activated potassium channel unclassified drug acetylcholine release article auditory stimulation calcium cell level cell activation cell function cell interaction cell motility cochlear nerve efferent nerve hair cell human hyperpolarization intracellular signaling membrane permeability nerve cell inhibition nerve cell plasticity nonhuman olivary nucleus olivocochlear hair cell potassium current signal processing sound transmission synapse synaptic transmission vibration Animals Cochlea Efferent Pathways Hair Cells, Auditory Humans Olivary Nucleus Receptors, Nicotinic Synapses Elgoyhen, A.B. Katz, E. The efferent medial olivocochlear-hair cell synapse
topic_facet	α9 and α10 Nicotinic receptors Cochlea Hair cells Nicotinic receptors Prestin SK channels Synaptic plasticity acetylcholine ion channel nicotinic receptor nicotinic receptor alpha10 nicotinic receptor alpha9 prestin small conductance calcium activated potassium channel unclassified drug acetylcholine release article auditory stimulation calcium cell level cell activation cell function cell interaction cell motility cochlear nerve efferent nerve hair cell human hyperpolarization intracellular signaling membrane permeability nerve cell inhibition nerve cell plasticity nonhuman olivary nucleus olivocochlear hair cell potassium current signal processing sound transmission synapse synaptic transmission vibration Animals Cochlea Efferent Pathways Hair Cells, Auditory Humans Olivary Nucleus Receptors, Nicotinic Synapses
description	Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca 2+ permeable and is coupled to a Ca 2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse. © 2011 Elsevier Ltd.
format	JOUR
author	Elgoyhen, A.B. Katz, E.
author_facet	Elgoyhen, A.B. Katz, E.
author_sort	Elgoyhen, A.B.
title	The efferent medial olivocochlear-hair cell synapse
title_short	The efferent medial olivocochlear-hair cell synapse
title_full	The efferent medial olivocochlear-hair cell synapse
title_fullStr	The efferent medial olivocochlear-hair cell synapse
title_full_unstemmed	The efferent medial olivocochlear-hair cell synapse
title_sort	efferent medial olivocochlear-hair cell synapse
url	http://hdl.handle.net/20.500.12110/paper_09284257_v106_n1-2_p47_Elgoyhen
work_keys_str_mv	AT elgoyhenab theefferentmedialolivocochlearhaircellsynapse AT katze theefferentmedialolivocochlearhaircellsynapse AT elgoyhenab efferentmedialolivocochlearhaircellsynapse AT katze efferentmedialolivocochlearhaircellsynapse
_version_	1782024888683331584

The efferent medial olivocochlear-hair cell synapse

Ejemplares similares