New kinetic model of drug release from swollen gels under non-sink conditions

A kinetic model of drug release from slabs of swollen gels under non-sink conditions is presented. The model is based on the mass transfer of drug from the interfacial region to an external solution of finite volume. Mass transfer is coupled with drug diffusion from the bulk gel towards the interfac...

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Autores principales: Bernik, D.L., Zubiri, D., Monge, M.E., Negri, R.M.
Formato: JOUR
Materias:
Drug diffusion
Drug release
Kinetic model
Mass transfer
Swollen gels
Adsorption
Concentration (process)
Drug products
Finite volume method
Polymers
Reaction kinetics
Gels
theophylline
xanthan
article
desorption
diffusion coefficient
drug adsorption
drug diffusion
drug release
equilibrium constant
kinetics
priority journal
steady state
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09277757_v273_n1-3_p165_Bernik
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_09277757_v273_n1-3_p165_Bernik
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spelling todo:paper_09277757_v273_n1-3_p165_Bernik2023-10-03T15:47:06Z New kinetic model of drug release from swollen gels under non-sink conditions Bernik, D.L. Zubiri, D. Monge, M.E. Negri, R.M. Drug diffusion Drug release Kinetic model Mass transfer Swollen gels Adsorption Concentration (process) Drug products Finite volume method Mass transfer Polymers Reaction kinetics Drug diffusion Drug release Kinetic model Swollen gels Gels theophylline xanthan article desorption diffusion coefficient drug adsorption drug diffusion drug release equilibrium constant kinetics priority journal steady state A kinetic model of drug release from slabs of swollen gels under non-sink conditions is presented. The model is based on the mass transfer of drug from the interfacial region to an external solution of finite volume. Mass transfer is coupled with drug diffusion from the bulk gel towards the interfacial region together with a non-equilibrium adsorption-desorption of drug to the polymer chains. The coupled kinetic equations obtained for the whole mentioned process allowed us to describe the time evolution of drug concentration released to the external volume, without the needs of keeping perfect sink conditions. The remaining bulk drug concentration can also be recovered. The model is tested with experimental data of teophylline release from xanthan gum gels placed in a steady-state Franz cell. It is observed that a pseudo steady-state concentration of free (non-adsorbed) drug is reached at the interfacial region after a short transitory time, t0. Besides, the kinetic features of the model have been simulated for several different parameters like slab dimensions, drug diffusion coefficient in the bulk gel, the equilibrium constant for the drug partition between gel and solution and the initial drug loading in the gel. © 2005 Elsevier B.V. All rights reserved. Fil:Bernik, D.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Monge, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Negri, R.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09277757_v273_n1-3_p165_Bernik
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Drug diffusion
Drug release
Kinetic model
Mass transfer
Swollen gels
Adsorption
Concentration (process)
Drug products
Finite volume method
Mass transfer
Polymers
Reaction kinetics
Drug diffusion
Drug release
Kinetic model
Swollen gels
Gels
theophylline
xanthan
article
desorption
diffusion coefficient
drug adsorption
drug diffusion
drug release
equilibrium constant
kinetics
priority journal
steady state
spellingShingle Drug diffusion
Drug release
Kinetic model
Mass transfer
Swollen gels
Adsorption
Concentration (process)
Drug products
Finite volume method
Mass transfer
Polymers
Reaction kinetics
Drug diffusion
Drug release
Kinetic model
Swollen gels
Gels
theophylline
xanthan
article
desorption
diffusion coefficient
drug adsorption
drug diffusion
drug release
equilibrium constant
kinetics
priority journal
steady state
Bernik, D.L.
Zubiri, D.
Monge, M.E.
Negri, R.M.
New kinetic model of drug release from swollen gels under non-sink conditions
topic_facet Drug diffusion
Drug release
Kinetic model
Mass transfer
Swollen gels
Adsorption
Concentration (process)
Drug products
Finite volume method
Mass transfer
Polymers
Reaction kinetics
Drug diffusion
Drug release
Kinetic model
Swollen gels
Gels
theophylline
xanthan
article
desorption
diffusion coefficient
drug adsorption
drug diffusion
drug release
equilibrium constant
kinetics
priority journal
steady state
description A kinetic model of drug release from slabs of swollen gels under non-sink conditions is presented. The model is based on the mass transfer of drug from the interfacial region to an external solution of finite volume. Mass transfer is coupled with drug diffusion from the bulk gel towards the interfacial region together with a non-equilibrium adsorption-desorption of drug to the polymer chains. The coupled kinetic equations obtained for the whole mentioned process allowed us to describe the time evolution of drug concentration released to the external volume, without the needs of keeping perfect sink conditions. The remaining bulk drug concentration can also be recovered. The model is tested with experimental data of teophylline release from xanthan gum gels placed in a steady-state Franz cell. It is observed that a pseudo steady-state concentration of free (non-adsorbed) drug is reached at the interfacial region after a short transitory time, t0. Besides, the kinetic features of the model have been simulated for several different parameters like slab dimensions, drug diffusion coefficient in the bulk gel, the equilibrium constant for the drug partition between gel and solution and the initial drug loading in the gel. © 2005 Elsevier B.V. All rights reserved.
format JOUR
author Bernik, D.L.
Zubiri, D.
Monge, M.E.
Negri, R.M.
author_facet Bernik, D.L.
Zubiri, D.
Monge, M.E.
Negri, R.M.
author_sort Bernik, D.L.
title New kinetic model of drug release from swollen gels under non-sink conditions
title_short New kinetic model of drug release from swollen gels under non-sink conditions
title_full New kinetic model of drug release from swollen gels under non-sink conditions
title_fullStr New kinetic model of drug release from swollen gels under non-sink conditions
title_full_unstemmed New kinetic model of drug release from swollen gels under non-sink conditions
title_sort new kinetic model of drug release from swollen gels under non-sink conditions
url http://hdl.handle.net/20.500.12110/paper_09277757_v273_n1-3_p165_Bernik
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