Coupling between transcription and alternative splicing

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The scenario of alternative splicing regulation is far more complex than the classical picture of a pre-mRNA being processed post-transcriptionally in more than one way. Introns are efficiently removed while transcripts are still being synthesized, supporting the idea of a co-transcriptional regulat...

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Autores principales:	Schor, I.E., Gómez Acuña, L.I., Kornblihtt, A.R., Wu J.Y.
Formato:	SER
Materias:	Alternative splicing Chromatin Co-transcriptional splicing Kinetic model RNA polymerase II-CTD Transcription-splicing coupling messenger RNA RNA polymerase II alternative RNA splicing article carcinogenesis chromatin structure genetic transcription human intron kinetics priority journal protein assembly regulatory mechanism RNA transcription spliceosome transcription regulation
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09273042_v_n_p1_Schor
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_09273042_v_n_p1_Schor
record_format	dspace
spelling	todo:paper_09273042_v_n_p1_Schor2023-10-03T15:46:55Z Coupling between transcription and alternative splicing Schor, I.E. Gómez Acuña, L.I. Kornblihtt, A.R. Wu J.Y. Alternative splicing Chromatin Co-transcriptional splicing Kinetic model RNA polymerase II-CTD Transcription-splicing coupling messenger RNA RNA polymerase II alternative RNA splicing article carcinogenesis chromatin structure genetic transcription human intron kinetics priority journal protein assembly regulatory mechanism RNA transcription spliceosome transcription regulation The scenario of alternative splicing regulation is far more complex than the classical picture of a pre-mRNA being processed post-transcriptionally in more than one way. Introns are efficiently removed while transcripts are still being synthesized, supporting the idea of a co-transcriptional regulation of alternative splicing. Evidence of a functional coupling between splicing and transcription has recently emerged as it was observed that properties of one process may affect the outcome of the other. Co-transcriptionality is thought to improve splicing efficiency and kinetics by directing the nascent pre-mRNA into proper spliceosome assembly and favoring splicing factor recruitment. Two models have been proposed to explain the coupling of transcription and alternative splicing: in the recruitment model, promoters and pol II status affect the recruitment to the transcribing gene of splicing factors or bifunctional factors acting on both transcription and splicing; in the kinetic model, differences in the elongation rate of pol II would determine the timing in which splicing sites are presented, and thus the outcome of alternative splicing decisions. In the later model, chromatin structure has emerged as a key regulator. Although definitive evidence for transcriptionally coupled alternative splicing alterations in tumor development or cancer pathogenesis is still missing, many alternative splicing events altered in cancer might be subject to transcription-splicing coupling regulation. © 2013 Springer-Verlag Berlin Heidelberg. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09273042_v_n_p1_Schor
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alternative splicing Chromatin Co-transcriptional splicing Kinetic model RNA polymerase II-CTD Transcription-splicing coupling messenger RNA RNA polymerase II alternative RNA splicing article carcinogenesis chromatin structure genetic transcription human intron kinetics priority journal protein assembly regulatory mechanism RNA transcription spliceosome transcription regulation
spellingShingle	Alternative splicing Chromatin Co-transcriptional splicing Kinetic model RNA polymerase II-CTD Transcription-splicing coupling messenger RNA RNA polymerase II alternative RNA splicing article carcinogenesis chromatin structure genetic transcription human intron kinetics priority journal protein assembly regulatory mechanism RNA transcription spliceosome transcription regulation Schor, I.E. Gómez Acuña, L.I. Kornblihtt, A.R. Wu J.Y. Coupling between transcription and alternative splicing
topic_facet	Alternative splicing Chromatin Co-transcriptional splicing Kinetic model RNA polymerase II-CTD Transcription-splicing coupling messenger RNA RNA polymerase II alternative RNA splicing article carcinogenesis chromatin structure genetic transcription human intron kinetics priority journal protein assembly regulatory mechanism RNA transcription spliceosome transcription regulation
description	The scenario of alternative splicing regulation is far more complex than the classical picture of a pre-mRNA being processed post-transcriptionally in more than one way. Introns are efficiently removed while transcripts are still being synthesized, supporting the idea of a co-transcriptional regulation of alternative splicing. Evidence of a functional coupling between splicing and transcription has recently emerged as it was observed that properties of one process may affect the outcome of the other. Co-transcriptionality is thought to improve splicing efficiency and kinetics by directing the nascent pre-mRNA into proper spliceosome assembly and favoring splicing factor recruitment. Two models have been proposed to explain the coupling of transcription and alternative splicing: in the recruitment model, promoters and pol II status affect the recruitment to the transcribing gene of splicing factors or bifunctional factors acting on both transcription and splicing; in the kinetic model, differences in the elongation rate of pol II would determine the timing in which splicing sites are presented, and thus the outcome of alternative splicing decisions. In the later model, chromatin structure has emerged as a key regulator. Although definitive evidence for transcriptionally coupled alternative splicing alterations in tumor development or cancer pathogenesis is still missing, many alternative splicing events altered in cancer might be subject to transcription-splicing coupling regulation. © 2013 Springer-Verlag Berlin Heidelberg.
format	SER
author	Schor, I.E. Gómez Acuña, L.I. Kornblihtt, A.R. Wu J.Y.
author_facet	Schor, I.E. Gómez Acuña, L.I. Kornblihtt, A.R. Wu J.Y.
author_sort	Schor, I.E.
title	Coupling between transcription and alternative splicing
title_short	Coupling between transcription and alternative splicing
title_full	Coupling between transcription and alternative splicing
title_fullStr	Coupling between transcription and alternative splicing
title_full_unstemmed	Coupling between transcription and alternative splicing
title_sort	coupling between transcription and alternative splicing
url	http://hdl.handle.net/20.500.12110/paper_09273042_v_n_p1_Schor
work_keys_str_mv	AT schorie couplingbetweentranscriptionandalternativesplicing AT gomezacunali couplingbetweentranscriptionandalternativesplicing AT kornblihttar couplingbetweentranscriptionandalternativesplicing AT wujy couplingbetweentranscriptionandalternativesplicing
_version_	1807324421692588032

Coupling between transcription and alternative splicing

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